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Antibiotics and anti-infectives

Cycloguanil

Also known as Cycloguanyl, Chlorguanide triazine, 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine

CAS 516-21-2Formula C11H14ClN5Molar mass 251.72 g/mol
3 suppliers listed
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Cycloguanil chemical structure, C11H14ClN5, CAS 516-21-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
516-21-2
Formula
C11H14ClN5
Molar mass
251.72 g/mol
HS code
293369
Category
Antibiotics and anti-infectives

What is Cycloguanil?

Plain description, key identifiers and synonyms

Cycloguanil is a triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. It has a role as an antiinfective agent, an antiparasitic agent, an antiprotozoal drug, an antimalarial, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an antifolate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
CAS number
516-21-2 CAS number cross-checked
Molecular formula
C11H14ClN5
UNII
26RM326WVN
InChIKey
QMNFFXRFOJIOKZ-UHFFFAOYSA-N
InChI
InChI=1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16)
SMILES (canonical and isomeric)
CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C

Synonyms

  • Cycloguanyl
  • Chlorguanide triazine
  • 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
  • WR 5473
  • 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
  • 1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine
  • cycloquanil
  • 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,2,5-triazine-2,4-diamine
  • Chlorcycloguanil
  • 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine
  • s-Triazine, 1,2-dihydro-1-(p-chlorophenyl)-4,6-diamino-2,2-dimethyl-
  • CGT
  • Cycloguanilum
  • 1,3,5-Triazine-2,4-diamine, 1,6-dihydro-1-(4-chlorophenyl)-6,6-dimethyl-
  • 4-Amino-6-p-chloroa
  • 1-p-Chlorophenyl-1,2-dihydro-2,2-dimethyl-4,6-diamino-s-triazine
  • 4-Amino-6-p-chloroanilino-1,2-dwuhydro-2,2-dwumethylo-1,3,5-trojazyna
  • 4-26-00-01176 (Beilstein Handbook Reference)
  • 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine
  • 1,3,5-Triazine-2,4-diamine,1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-
  • 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3, 5-triazine-2,4-diamine
  • 1,3,5-Triazine-2,4-diamine, 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-
  • VIL

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
251.72 g/molcalc.
Exact mass
251.0938 Dacalc.
LogP (octanol/water)
1.53calc.
Topological polar surface area
80 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.27calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=NC=NCN1c1ccccc1

C1=NC=NCN1c1ccccc1

2 rings, 12 atoms.

129 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Cycloguanil suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers
  • Innovapharm Ltd
    Ukraine, KievUnclaimed profile
    CycloguanilGrade, purity and minimum order on request
    Price on request
    View
  • Specs
    Netherlands, ZoetermeerUnclaimed profile
    CycloguanilGrade, purity and minimum order on request
    Price on request
    View
  • Synblock Inc
    Canada, MontrealUnclaimed profile
    CycloguanilGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 3 countries

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Cycloguanil price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antimalarials
  • Folic Acid Antagonists

Roles

  • antifolate
  • antiinfective agent
  • antimalarial
  • antimetabolite
  • antimicrobial agent
  • antimicrobial drug
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • enzyme inhibitor
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cycloguanil is traded under.

HS 2933.69Indicative HS code

Compounds containing an unfused triazine ring (whether or not hydrogenated) in the…

World exports in 2024
$2.46B
+1.8% vs 2023, imports $2.44B
2019 to 2024
Top exporters
  1. China53.6%
  2. Germany11.5%
  3. India * partner reported8.4%
Top importers
  1. United States13.5%
  2. Brazil9.6%
  3. Germany9.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cycloguanil is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cycloguanil, based on the data on this page

What is Cycloguanil?

Cycloguanil is a triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil.

What is the CAS number of Cycloguanil?

The CAS registry number of Cycloguanil is 516-21-2.

What is the molecular formula and weight of Cycloguanil?

The molecular formula of Cycloguanil is C11H14ClN5 and its molar mass is 251.72 g/mol.

What is Cycloguanil used for?

Known uses and roles of Cycloguanil include antifolate, antiinfective agent, antimalarial, antimetabolite, antimicrobial agent and 8 more.

Is Cycloguanil hazardous?

No GHS hazard classification for Cycloguanil is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Cycloguanil?

Cycloguanil is usually classified under HS code 293369 (Compounds containing an unfused triazine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cycloguanil?

CompoundList lists 3 suppliers of Cycloguanil in Canada, Netherlands and Ukraine. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cycloguanil?

Suppliers quote Cycloguanil on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cycloguanil

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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