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Amino acids and derivatives

D-Serine

Also known as (R)-Serine, (R)-2-amino-3-hydroxypropanoic acid, (2R)-2-amino-3-hydroxypropanoic acid

CAS 312-84-5Formula C3H7NO3Molar mass 105.09 g/molEC 206-229-4
GHS signal word: Warning. Pictograms: Harmful or irritant 38 suppliers listed
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D-Serine chemical structure, C3H7NO3, CAS 312-84-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
312-84-5
Formula
C3H7NO3
Molar mass
105.09 g/mol
EC number
206-229-4
HS code
292250
Category
Amino acids and derivatives

What is D-Serine?

Plain description, key identifiers and synonyms

D-serine is the R-enantiomer of serine. It has a role as a NMDA receptor agonist, an Escherichia coli metabolite and a human metabolite. It is a D-alpha-amino acid and a serine. It is a conjugate base of a D-serinium. It is a conjugate acid of a D-serinate. It is an enantiomer of a L-serine. It is a tautomer of a D-serine zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R)-2-amino-3-hydroxypropanoic acid
CAS number
312-84-5 CAS number cross-checkedOther or deprecated CAS: 13095-79-9
EC number
206-229-4
Molecular formula
C3H7NO3
UNII
1K77H2Z9B1
MDL number
MFCD00004269
InChIKey
MTCFGRXMJLQNBG-UWTATZPHSA-N
InChI
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
Canonical SMILES
NC(CO)C(=O)O
Isomeric SMILES
C([C@H](C(=O)O)N)O

Synonyms

  • (R)-Serine
  • (R)-2-amino-3-hydroxypropanoic acid
  • (2R)-2-amino-3-hydroxypropanoic acid
  • Serine D-form
  • Serine, D-
  • D-Serin
  • (d)-Serine
  • (R)-2-Amino-3-hydroxy-propionic acid
  • (2R)-2-azaniumyl-3-hydroxypropanoate
  • H-D-Ser-OH
  • D-2-Amino-3-hydroxypropionic Acid
  • D-Ser
  • DSN
  • d-(+)-serine
  • (2R)-2-amino-3-hydroxypropanoate
  • (2R)-2-amino-3-hydroxy-propanoic acid
  • D-Serine, Serine, D- (8CI), (R)-2-Amino-3-hydroxypropanoic acid, (R)-Serine, NSC 77689
  • D-b-Hydroxyalanine
  • [3h]-d-serine
  • (2R)-serine
  • (R)-2-Amino-3-hydroxypropionic acid
  • 1pb8
  • Biomol-NT_000197
  • D-Serine, >=98% (TLC)
  • (R)-2-amino-3-hydroxypropanoate
Show all 28 synonyms
  • R(-)-2-Amino-3-hydroxypropionic acid
  • Sdccgsbi-0051058.p002
  • D-Serine / (R)-2-Amino-3-hydroxypropanoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
105.09 g/molcalc.
Exact mass
105.0426 Dacalc.
LogP (octanol/water)
-1.61calc.
Topological polar surface area
83.55 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
7calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

D-Serine suppliers

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All 38 suppliers
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Where suppliers are based

38 suppliers in 7 countries

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D-Serine price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • Escherichia coli metabolite
  • NMDA receptor agonist
  • animal metabolite
  • antipsychotic agent
  • bacterial metabolite
  • central nervous system depressant
  • central nervous system drug
  • eukaryotic metabolite
  • excitatory amino acid agonist
  • human metabolite
  • mammalian metabolite
  • metabolite
  • neurotransmitter agent
  • pharmaceutical
  • prokaryotic metabolite
  • psychotropic drug
  • tranquilizing drug

Pharmacology

D-Serine is a non-essential amino acid and dextro isomer of serine with antipsychotic activity. D-serine is a selective full agonist at the glycine site of N-methyl-D-aspartate (NMDA)-type glutamate receptor. Hypofunction of NMDA type of neurotransmission is believed to play a major role in pathophysiology of schizophrenia, therefore, administration of D-serine and subsequent activation of NMDA receptors may alleviate psychotic tendencies.

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code D-Serine is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for D-Serine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about D-Serine, based on the data on this page

What is D-Serine?

D-serine is the R-enantiomer of serine. It has a role as a NMDA receptor agonist, an Escherichia coli metabolite and a human metabolite. It is a D-alpha-amino acid and a serine. It is a conjugate base of a D-serinium. It is a conjugate acid of a D-serinate. It is an enantiomer of a L-serine.

What is the CAS number of D-Serine?

The CAS registry number of D-Serine is 312-84-5. Other or deprecated CAS numbers: 13095-79-9.

What is the molecular formula and weight of D-Serine?

The molecular formula of D-Serine is C3H7NO3 and its molar mass is 105.09 g/mol.

What is D-Serine used for?

Known uses and roles of D-Serine include escherichia coli metabolite, nmda receptor agonist, animal metabolite, antipsychotic agent, bacterial metabolite and 12 more.

Is D-Serine hazardous?

D-Serine carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of D-Serine?

D-Serine is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy D-Serine?

CompoundList lists 38 suppliers of D-Serine in China, United States, Germany, Spain and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy D-Serine in India?

1 supplier in India list D-Serine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of D-Serine?

Suppliers quote D-Serine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle D-Serine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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