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Oncology and immunology drugs

Dabrafenib

Also known as Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-, N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide, Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-

CAS 1195765-45-7Formula C23H20F3N5O2S2Molar mass 519.57 g/molEC 689-166-9
GHS signal word: Warning. Pictograms: Serious health hazard, Hazardous to the environment 91 suppliers listed Drug substance
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Dabrafenib chemical structure, C23H20F3N5O2S2, CAS 1195765-45-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1195765-45-7
Formula
C23H20F3N5O2S2
Molar mass
519.57 g/mol
EC number
689-166-9
HS code
293590
Category
Oncology and immunology drugs

What is Dabrafenib?

Plain description, key identifiers and synonyms

Dabrafenib is an organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma. It has a role as an anticoronaviral agent, an antineoplastic agent and a B-Raf inhibitor. It is a sulfonamide, an organofluorine compound, an aminopyrimidine and a member of 1,3-thiazoles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
CAS number
1195765-45-7 CAS number cross-checkedOther or deprecated CAS: 1195768-06-9
EC number
689-166-9
Molecular formula
C23H20F3N5O2S2
UNII
QGP4HA4G1B
MDL number
MFCD17215684
InChIKey
BFSMGDJOXZAERB-UHFFFAOYSA-N
InChI
InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
SMILES (canonical and isomeric)
CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

Synonyms

  • Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-
  • N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
  • Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-
  • N-(3-(5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
  • N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene-1-sulfonamide
  • N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
  • dabrafenibum
  • N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzene-1-sulfonamide
  • BRAF Inhibitor GSK2118436
  • N-(3-(5-(2-aminopyrimidin-4-yl)-2-(1,1-dimethylethyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
  • Tafinlar
  • Dabrafenib (GSK2118436)
  • Dabrafenib (Free Base)
  • N-(3-(5-(2-aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
  • GSK 2118436
  • N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
  • Dabrafenib (USAN)
  • N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
  • N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
  • 1195765-45-7 (free base)
  • Dabrafenib?
  • Dabrafenib (Standard)
  • Dabrafenib, kb-57246
  • GSK 2118436A
  • Sdccgsbi-0654477.p001
Show all 28 synonyms
  • N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide
  • N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfo
  • N-(3-(5-(2-Aminopyrimidine-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
519.57 g/molcalc.
Exact mass
519.1011 Dacalc.
LogP (octanol/water)
5.36calc.
Topological polar surface area
110.9 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
5calc.
Heavy atoms
35calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.17calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S(=O)(Nc1cccc(-c2ncsc2-c2ccncn2)c1)c1ccccc1

O=S(=O)(Nc1cccc(-c2ncsc2-c2ccncn2)c1)c1ccccc1

4 rings, 27 atoms.

15 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
  • H361fdSuspected of damaging fertility. Suspected of damaging the unborn child.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dabrafenib suppliers

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Where suppliers are based

91 suppliers in 14 countries

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Dabrafenib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Protein Kinase Inhibitors

Roles

  • B-Raf inhibitor
  • anticoronaviral agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • enzyme inhibitor
  • pharmaceutical
  • protective agent
  • protein kinase inhibitor
  • renoprotective agent

Pharmacology

Dabrafenib is a Kinase Inhibitor. The mechanism of action of dabrafenib is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 2B6 Inducer, and Cytochrome P450 2C8 Inducer, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 2C19 Inducer, and Organic Anion Transporting Polypeptide 1B1 Inhibitor, and Organic Anion Transporting Polypeptide 1B3 Inhibitor, and Organic Anion Transporter 1 Inhibitor, and Organic Anion Transporter 3 Inhibitor, and Breast Cancer Resistance Protein Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dabrafenib is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dabrafenib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dabrafenib, based on the data on this page

What is Dabrafenib?

Dabrafenib is an organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma. It has a role as an anticoronaviral agent, an antineoplastic agent and a B-Raf inhibitor. It is a sulfonamide, an organofluorine compound, an aminopyrimidine and a member of 1,3-thiazoles.

What is the CAS number of Dabrafenib?

The CAS registry number of Dabrafenib is 1195765-45-7. Other or deprecated CAS numbers: 1195768-06-9.

What is the molecular formula and weight of Dabrafenib?

The molecular formula of Dabrafenib is C23H20F3N5O2S2 and its molar mass is 519.57 g/mol.

What is Dabrafenib used for?

Known uses and roles of Dabrafenib include anticancer drugs in pharmaceuticals, biochemical and pharmacological tools in research and laboratory, b-raf inhibitor, anticoronaviral agent, antimicrobial agent and 9 more.

Is Dabrafenib hazardous?

Dabrafenib carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child, suspected of damaging fertility. suspected of damaging the unborn child, may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dabrafenib?

Dabrafenib is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dabrafenib?

CompoundList lists 91 suppliers of Dabrafenib in China, United States, Germany, Spain and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dabrafenib in India?

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What is the price of Dabrafenib?

Suppliers quote Dabrafenib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dabrafenib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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