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Murcko scaffold

Ring system with 4 rings and 27 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
16
With full pages
3
Scaffold SMILES

O=S(=O)(Nc1cccc(-c2ncsc2-c2ccncn2)c1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(Nc1cccc(-c2ncsc2-c2ccncn2)c1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

Dabrafenib chemical structure, C23H20F3N5O2S2, CAS 1195765-45-7
Dabrafenib
CAS 1195765-45-7C23H20F3N5O2S2
Dabrafenib mesylate chemical structure, C24H24F3N5O5S3, CAS 1195768-06-9
Dabrafenib mesylate
CAS 1195768-06-9C24H24F3N5O5S3
Hydroxy dabrafenib chemical structure, C23H20F3N5O3S2, CAS 1195767-77-1
Hydroxy dabrafenib
CAS 1195767-77-1C23H20F3N5O3S2
N-(3-(5-(2-Chloro-4-pyrimidinyl)-2-(1,1-diethylethyl)-1,3-thiazol-4-yl)-2-fluoraphenyl)-2,6-difluorobenzenesulfonamide chemical structure, C23H18ClF3N4O2S2, CAS 1195768-23-0
N-(3-(5-(2-Chloro-4-pyrimidinyl)-2-(1,1-diethylethyl)-1,3-thiazol-4-yl)-2-fluoraphenyl)-2,6-difluorobenzenesulfonamide
CAS 1195768-23-0C23H18ClF3N4O2S2
Carboxy darafenib chemical structure, C23H18F3N5O4S2, CAS 1195873-54-1
Carboxy darafenib
CAS 1195873-54-1C23H18F3N5O4S2
N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide chemical structure, C22H16ClF3N4O2S2, CAS 1195768-22-9
N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide
CAS 1195768-22-9C22H16ClF3N4O2S2
Desmethyl dabrafenib chemical structure, C22H18F3N5O2S2, CAS 1195765-47-9
Desmethyl dabrafenib
CAS 1195765-47-9C22H18F3N5O2S2
Dabrafenib-d9 chemical structure, C23H20F3N5O2S2, CAS 1423119-98-5
Dabrafenib-d9
CAS 1423119-98-5C23H20F3N5O2S2
Dabrafenib impurity 17 chemical structure, C22H16F3N5O2S2, CAS 1613724-51-8
Dabrafenib impurity 17
CAS 1613724-51-8C22H16F3N5O2S2
N-(4-(2-(tert-Butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-5-yl)pyrimidin-2-yl)propionamide chemical structure, C26H24F3N5O3S2, CAS 2226608-94-0
N-(4-(2-(tert-Butyl)-4-(3-((2,6-difluorophenyl)sulfonamido)-2-fluorophenyl)thiazol-5-yl)pyrimidin-2-yl)propionamide
CAS 2226608-94-0C26H24F3N5O3S2
N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide chemical structure, C23H21F2N5O2S2, CAS 3110019-42-3
N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)phenyl)-2,6-difluorobenzenesulfonamide
CAS 3110019-42-3C23H21F2N5O2S2
N-[3-[2-Amino-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide chemical structure, C19H11ClF3N5O2S2, CAS 3080339-16-5
N-[3-[2-Amino-5-(2-chloropyrimidin-4-yl)thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
CAS 3080339-16-5C19H11ClF3N5O2S2
Carboxy dabrafenib disodium salt chemical structure, C23H17F3N5Na2O4S2+, CAS 1195767-90-8
Carboxy dabrafenib disodium salt
CAS 1195767-90-8C23H17F3N5Na2O4S2+
Benzenesulfonamide, 2-amino-N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-6-fluoro- chemical structure, C23H22F2N6O2S2, CAS 2017554-98-0
Benzenesulfonamide, 2-amino-N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-6-fluoro-
CAS 2017554-98-0C23H22F2N6O2S2
Dabrafenib impurity 19 chemical structure, C24H21F3N4O3S2, CAS 1907654-22-1
Dabrafenib impurity 19
CAS 1907654-22-1C24H21F3N4O3S2
Dabrafenib impurity 38 chemical structure, C23H20F3N5O3S2, CAS 3052138-43-6
Dabrafenib impurity 38
CAS 3052138-43-6C23H20F3N5O3S2