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Dapt

Also known as GSI-IX, tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate, tert-butyl (2S)-2-(((2S)-2-((2-(3,5-difluorophenyl)acetyl)amino)propanoyl)amino)-2-phenylacetate

CAS 208255-80-5Formula C23H26F2N2O4Molar mass 432.47 g/mol
11 suppliers listed
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Dapt chemical structure, C23H26F2N2O4, CAS 208255-80-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
208255-80-5
Formula
C23H26F2N2O4
Molar mass
432.47 g/mol
HS code
292429
Category
Peptides

What is Dapt?

Plain description, key identifiers and synonyms

DAPT is a dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. It is a gamma-secretase inhibitor. It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a tert-butyl ester, a carboxylic ester, a difluorobenzene and a dipeptide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
CAS number
208255-80-5 CAS number cross-checked
Molecular formula
C23H26F2N2O4
MDL number
MFCD04974585
InChIKey
DWJXYEABWRJFSP-XOBRGWDASA-N
InChI
InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
Canonical SMILES
CC(NC(=O)Cc1cc(F)cc(F)c1)C(=O)NC(C(=O)OC(C)(C)C)c1ccccc1
Isomeric SMILES
C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

Synonyms

  • GSI-IX
  • tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
  • tert-butyl (2S)-2-(((2S)-2-((2-(3,5-difluorophenyl)acetyl)amino)propanoyl)amino)-2-phenylacetate
  • DAPT (GSI-IX)
  • gamma-Secretase Inhibitor IX
  • tert-butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate
  • GSI IX
  • DAPT (GMP)
  • (S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate
  • Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
  • one of |A-Secretase inhibitor
  • tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate
  • DAPT (peptide)
  • (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu
  • N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
  • N-(2FPhAc)Ala-phenyl-Gly t-butyl ester
  • DAPT,GSI-IX
  • DAPT?
  • N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
  • Dwjxyeabwrjfsp-xobrgwd
  • N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester
  • (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester
  • N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine tbutyl ester
  • ((S)-Tert-Butyl 2-((S)-2-(2-(3,5-Difluorophenyl)Acetamido)Propanamido)-2-Phenylacetate)
  • 2-Methyl-2-propanyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate
Show all 28 synonyms
  • N-{N-[2-(3,5-Difluorophenyl)acetyl]-(S)-alanyl}- (S)-phenylglycine tert-butyl ester
  • (S)-{(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-propionylamino}-phenyl-acetic acid tert-butyl ester
  • t-butyl (2s)-2-[[(2s)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
432.47 g/molcalc.
Exact mass
432.1861 Dacalc.
LogP (octanol/water)
3.21calc.
Topological polar surface area
84.5 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
7calc.
Heavy atoms
31calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CNC(=O)Cc1ccccc1)NCc1ccccc1

O=C(CNC(=O)Cc1ccccc1)NCc1ccccc1

2 rings, 21 atoms.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Dapt suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 11 suppliers
11 of 11 offers
  • qcchemical.com
    Unclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • Lancrix Chemicals
    ChinaUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • Apichem Chemical Technology Co., Ltd.
    China ManufacturerUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • 1st Scientific LLC
    China, NanjingUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • Axon Medchem
    United States, RestonUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • ChemFaces
    China, WuhanUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • Excenen Pharmatech Co., Ltd.
    China, GuangzhouUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • Hello Bio
    United Kingdom, AvonmouthUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • LKT Laboratories, Inc.
    United States, St. PaulUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
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  • Pharmacore Co., Limited
    China, KunshanUnclaimed profile
    DaptGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

11 suppliers in 3 countries

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Dapt price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • enzyme inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dapt is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dapt is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dapt, based on the data on this page

What is Dapt?

DAPT is a dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. It is a gamma-secretase inhibitor. It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor.

What is the CAS number of Dapt?

The CAS registry number of Dapt is 208255-80-5.

What is the molecular formula and weight of Dapt?

The molecular formula of Dapt is C23H26F2N2O4 and its molar mass is 432.47 g/mol.

What is Dapt used for?

Known uses and roles of Dapt include enzyme inhibitor.

Is Dapt hazardous?

No GHS hazard classification for Dapt is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Dapt?

Dapt is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dapt?

CompoundList lists 11 suppliers of Dapt in China, United States and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Dapt?

Suppliers quote Dapt on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dapt

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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