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Ketone and ester solvents

delta-Gluconolactone

Also known as gluconolactone, D-glucono-1,5-lactone, Gluconic acid lactone

CAS 90-80-2Formula C6H10O6Molar mass 178.14 g/molEC 202-016-5
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delta-Gluconolactone chemical structure, C6H10O6, CAS 90-80-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White crystals
Melting point
155 °C
Density
1.610 g/cm³ at -5 °C
Solubility
In water, 5.9 × 10⁺⁵ mg/L at 25 °C
HS code
293220
Category
Ketone and ester solvents
Illustrative photo, colourless crystals in small glass vials on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is delta-Gluconolactone?

Plain description, key identifiers and synonyms

D-glucono-1,5-lactone is an aldono-1,5-lactone obtained from D-gluconic acid. It has a role as an animal metabolite and a mouse metabolite. It is a gluconolactone and an aldono-1,5-lactone. It is functionally related to a D-gluconic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one
CAS number
90-80-2 CAS number cross-checkedOther or deprecated CAS: 1335-57-5, 135820-79-0, 4253-68-3, 54910-68-8
EC number
202-016-5
Molecular formula
C6H10O6
UNII
WQ29KQ9POT
MDL number
MFCD00006647
INCI name
GLUCONOLACTONE
InChIKey
PHOQVHQSTUBQQK-SQOUGZDYSA-N
InChI
InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1
Canonical SMILES
O=C1OC(CO)C(O)C(O)C1O
Isomeric SMILES
C([C@@H]1[C@H]([C@@H]([C@H](C(=O)O1)O)O)O)O

Synonyms

  • gluconolactone
  • D-glucono-1,5-lactone
  • Gluconic acid lactone
  • (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one
  • D-Gluconic acid lactone
  • D-Gluconic acid delta-lactone
  • 1,5-D-Gluconolactone
  • Gluconic lactone
  • (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one
  • Gluconic delta-lactone
  • delta-D-Gluconolactone
  • Glucono delta lactone
  • Deltagluconolactone
  • Fujiglucon
  • Lysactone
  • Riken lactone
  • INS NO.575
  • Gluconolactone (USP)
  • GlyTouCan:G58393QV
  • d-(+)-Glucono-1,5-lactone
  • 1,5-Gluconolactone
  • Glucono delta-lactone
  • D-Aldonolactone
  • glucono-delta-lactone
  • D-delta-Gluconolactone
Show all 34 synonyms
  • D-Gluconic delta-lactone
  • Glucarolactone
  • D-Gluconic acid-delta-lactone
  • beta-Glucono-1,5-lactone
  • D-(+)-Gluconic acid delta-lactone
  • Gluconic Acid delta-Lactone
  • D-threo-Aldono-1,5-lactone
  • Gluconic Acid Anhydride
  • Gluconic acid, delta-lactone, D-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White crystalsexp.
Taste
Sweet tasteexp.
Melting point
155 °Cexp.
Density
1.610 g/cm³ at -5 °Cexp.
Solubility
In water, 5.9 × 10⁺⁵ mg/L at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
178.14 g/molcalc.
Exact mass
178.0477 Dacalc.
LogP (octanol/water)
-3.01calc.
Topological polar surface area
107.2 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
1calc.
Heavy atoms
12calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.83calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCCO1

O=C1CCCCO1

1 ring, 7 atoms, the delta-Valerolactone ring system.

353 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

delta-Gluconolactone suppliers

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All 63 suppliers
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Where suppliers are based

63 suppliers in 12 countries

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delta-Gluconolactone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Component of many cleaning compounds because of the sequestering ability of the gluconate radical which remains active in alkaline solutions, in the dairy industry to prevent milkstone, in breweries to prevent beerstone, as latent acid catalyst for acid colloid resins, particularly in textile printing, as a coagulant for tofu.

Sequestering agent.

Food additive.

Veterinary medication:.

Industrial uses: Processing aids not otherwise specified, Intermediate, Chelating agent.

Consumer uses: Processing aids not otherwise specified, Chelating agent.

Use classes: Safer Chemical Classes, Food additives, Cosmetics.

Cosmetic ingredient, INCI name GLUCONOLACTONE(chelating, skin conditioning)

Roles

  • animal metabolite
  • eukaryotic metabolite
  • mammalian metabolite
  • metabolite
  • mouse metabolite

Functional uses

  • Antioxidant
  • Chelating agent
  • Chemical reaction regulator
  • Flavouring and nutrient
  • Food preservative
  • Fragrance
  • Humectant
  • Leavening agent
  • Preservative
  • Processing aids not otherwise specified
  • Softener and conditioner
  • pH regulating agent

Cosmetic functions

  • Chelating
  • Skin conditioning

Pharmacology

Gluconolactone is a Calculi Dissolution Agent. The mechanism of action of gluconolactone is as an Irrigation.

How it is made

By oxidation of glucose with bromine water ... by oxidation of glucose in Acetobacter suboxydans

Glucono-1,5-lactone crystallizes from a supersaturated aqueous gluconic acid solution between 36 and 57 °C. A two-step continuous crystallization is said to result in increased productivity per unit volume under conditions that are favorable in terms of energy consumption. In the first step, a crystalline suspension (3 to 10 % crystalline material) is produced in a supersaturated gluconic acid solution held at 65 to 75 °C.

Read more

The second step involves controlled cooling to 40 to 45 °C, followed by a period of crystal maturation at constant temperature. A portion of the resulting crystalline suspension is then recycled to the first step. ... The 1,5-lactone may also be obtained from an aqueous gluconic acid solution by dehydration involving azeotropic distillation with alcohols, followed by crystallization from the alcohol-containing residue. Crystallization above 70 °C leads to the 1,4-lactone.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Food additive

United States

  • Safer Choice ingredient list (USA)
  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code delta-Gluconolactone is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for delta-Gluconolactone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about delta-Gluconolactone, based on the data on this page

What is delta-Gluconolactone?

D-glucono-1,5-lactone is an aldono-1,5-lactone obtained from D-gluconic acid. It has a role as an animal metabolite and a mouse metabolite. It is a gluconolactone and an aldono-1,5-lactone. It is functionally related to a D-gluconic acid.

What is the CAS number of delta-Gluconolactone?

The CAS registry number of delta-Gluconolactone is 90-80-2. Other or deprecated CAS numbers: 1335-57-5, 135820-79-0, 4253-68-3.

What is the molecular formula and weight of delta-Gluconolactone?

The molecular formula of delta-Gluconolactone is C6H10O6 and its molar mass is 178.14 g/mol.

What is delta-Gluconolactone used for?

Component of many cleaning compounds because of the sequestering ability of the gluconate radical which remains active in alkaline solutions, in the dairy industry to prevent milkstone, in breweries to prevent beerstone, as latent acid catalyst for acid colloid resins, particularly in textile printing, as a coagulant…

Is delta-Gluconolactone hazardous?

No GHS hazard classification for delta-Gluconolactone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of delta-Gluconolactone?

delta-Gluconolactone is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy delta-Gluconolactone?

CompoundList lists 63 suppliers of delta-Gluconolactone in China, United States, India, Belgium and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy delta-Gluconolactone in India?

6 suppliers in India list delta-Gluconolactone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of delta-Gluconolactone?

Suppliers quote delta-Gluconolactone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle delta-Gluconolactone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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