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Insecticides and acaricides

Demeton

Also known as Systox, Mercaptofos, Systemox

CAS 8065-48-3Formula C16H38O6P2S4Molar mass 516.69 g/molEC 620-378-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Hazardous to the environment
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Demeton chemical structure, C16H38O6P2S4, CAS 8065-48-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Amber, oily liquid
Melting point
-25 °C
Boiling point
134 °C
Density
Relative density (water = 1): 1.1
Flash point
45 °C
HS code
293090
Category
Insecticides and acaricides
UN number
UN 3017
Illustrative photo, an IBC tote of amber liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Demeton?

Plain description, key identifiers and synonyms

Demeton is an oily liquid with an amber color and an odor of sulfur. Used as an agricultural insecticide. (EPA, 1998)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
diethoxy-(2-ethylsulfanylethoxy)-sulfanylidene-λ5-phosphane, 1-diethoxyphosphorylsulfanyl-2-ethylsulfanylethane
CAS number
8065-48-3 CAS number cross-checked
EC number
620-378-6
Molecular formula
C16H38O6P2S4
UNII
F74QXK6K3Q
MDL number
MFCD00466988
InChIKey
FAXIJTUDSBIMHY-UHFFFAOYSA-N
InChI
InChI=1S/2C8H19O3PS2/c1-4-10-12(9,11-5-2)14-8-7-13-6-3;1-4-9-12(13,10-5-2)11-7-8-14-6-3/h2*4-8H2,1-3H3
SMILES (canonical and isomeric)
CCOP(=O)(OCC)SCCSCC.CCOP(=S)(OCC)OCCSCC

Synonyms

  • Systox
  • Mercaptofos
  • Systemox
  • Septox
  • Demox
  • Ethyl systox
  • Bayer 8169
  • BAY 10756
  • ENT 17,295
  • beta-Ethylmercaptoethyl diethyl thionophosphate
  • O,O-Diethyl 2-ethylmercaptoethyl thiophosphate
  • Diethoxythiophosphoric acid ester of 2-ethylmercaptoethanol
  • Dematon
  • o-o-Diethyl-o(and s)-2-(ethylthio)ethyl phosphorothioate mixture
  • Demeton (O&S)
  • diethoxy-(2-ethylsulfanylethoxy)-sulfanylidene-lambda5-phosphane, 1-diethoxyphosphorylsulfanyl-2-ethylsulfanylethane
  • Demeton (OS)
  • Demeton(O&S)
  • Demeton (O+S)
  • Phosphorothioic acid, O,O-diethyl O-(2-(ethylthio)ethyl) ester, mixt. with O,O-diethyl S-(2-(ethylthio)ethyl) phosphorothioate
  • Demeton (O+S) 10 microg/mL in Cyclohexane
  • Demeton (O+S) 1000 microg/mL in Acetone
  • Demeton (O+S) 100 microg/mL in Acetonitrile
  • diethoxy-(2-ethylsulfanylethoxy)-thioxo-lambda5-phosphane, 1-diethoxyphosphorylsulfanyl-2-ethylsulfanyl-ethane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Amber, oily liquidexp.
Odour
Technical grade demeton has a pronounced mercaptan-like odorexp.
Melting point
-25 °Cexp.
Boiling point
134 °Cexp.
Density
Relative density (water = 1): 1.1exp.
Flash point
45 °Cexp.
Autoignition temperature
463.9 °Cexp.
Solubility
In water, 6.66 × 10⁺² mg/L at 25 °Cexp.
Vapour pressure
3.4 × 10⁻⁴ mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
516.69 g/molcalc.
Exact mass
516.1026 Dacalc.
LogP (octanol/water)
6.71calc.
Topological polar surface area
63.22 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
18calc.
Heavy atoms
28calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H400Very toxic to aquatic life.
Precautionary statements (14)
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3017
Transport hazard class
6.1
Packing group
I

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Demeton suppliers

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Demeton price

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Uses and applications

What the substance is used for, by industry and function

The active ingredient is no longer contained in any registered pesticide products ... "cancelled.".

Systemic insecticide (absorbed by plant, which then becomes toxic to sucking and chewing insects).

Systox has been used widely as systemic insecticide for ornamentals and nursery stock.

Demeton is a systemic insecticide effective against sap-feeding insects and mites.

Systemic insecticide-acaricide.

Use classes: Acaricides.

How it is made

Reaction of o,o-diethylphosphorochloridodithioate with beta-hydroxyethyl ethyl sulfide in presence of metallic sodium & reaction of diethyl phosphite & beta-ethylmercaptoethyl thiocyanate in presence of metallic sodium to yield the mixture, demeton (systox)

/It is prepared/ by reaction of 2-hydroxyethyl sulfide on diethyl phosphorochloridothioate ... In toluene in presence of anhydrous sodium carbonate & metallic copper. Isomerization occurs & resultant product is approx 65-35 mixture of ... (Demeton-o & demeton-s).

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-118-00-8

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Demeton is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Demeton is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Demeton, based on the data on this page

What is Demeton?

Demeton is an oily liquid with an amber color and an odor of sulfur. Used as an agricultural insecticide. (EPA, 1998)

What is the CAS number of Demeton?

The CAS registry number of Demeton is 8065-48-3.

What is the molecular formula and weight of Demeton?

The molecular formula of Demeton is C16H38O6P2S4 and its molar mass is 516.69 g/mol.

What is Demeton used for?

The active ingredient is no longer contained in any registered pesticide products ... "cancelled.". Systemic insecticide (absorbed by plant, which then becomes toxic to sucking and chewing insects). Systox has been used widely as systemic insecticide for ornamentals and nursery stock.

Is Demeton hazardous?

Demeton carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Demeton?

Demeton is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Demeton?

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What is the price of Demeton?

Suppliers quote Demeton on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Demeton

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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