Deslorelin
Also known as D-Trp LHRH-PEA, Deslorelina, Desloreline
Key facts
What buyers check first
What is Deslorelin?
Plain description, key identifiers and synonyms
Deslorelin is an oligopeptide.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
- CAS number
- 57773-65-6 CAS number cross-checked
- EC number
- 637-335-2
- Molecular formula
- C64H83N17O12
- UNII
- TKG3I66TVE
- MDL number
- MFCD00167401
- InChIKey
- GJKXGJCSJWBJEZ-XRSSZCMZSA-N
- InChI
- InChI=1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1
- Canonical SMILES
- CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1
- Isomeric SMILES
- CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
Synonyms
- D-Trp LHRH-PEA
- Deslorelina
- Desloreline
- Deslorelinum
- D-Trp-LHRH-PEA
- Somagard (as acetate)
- 6-Trp-10-N-Et-glynh2-LHRH
- GNRH, trp(6)-N-Et-glynh2(10)-
- LHRH, Trp(6)-N-Et-GlyNH2(10)-
- LHRH, tryptophyl(6)-N-ethylglycinamide(10)-
- Somagard
- Bachem 9022
- 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
- (D-Trp6,des-Gly10)-LH-RH ethylamide
- GNRH (D-Trp6,pro9-net)
- Deslorelin?
- (D-Trp6,Pro9-NHEt)LH-RH
- (de-Gly10,D-Trp6,Pro-NHEt)-LH-RH
- (Des-Gly10(D-Tro6)-LH-RH ethylamide
- LHRH-T
- (D-Trp(sub 6)-pro(sup 9)-NEt)-GNRH
- Deslorelin (USAN/INN)
- (D-Trp6,des-Gly-NH210)-LH-RH ethylamide
- D-Trp(sup 6)-pro(sup 9)-N-ethylamide-LHRH
- (D-Trp(sup 6)-pro(sup 9))-LHRH ethylamide
Show all 27 synonymsShow fewer synonyms
- Des-Gly-10-Trp-6-ethylamide-LHRH
- GnRH, Trp(6)-N-Et-ProNH2(9)-
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 1,282.48 g/molcalc.Computed value |
|---|---|
| Exact mass | 1,281.6407 Dacalc.Computed value |
| LogP (octanol/water) | -0.76calc.Computed value |
| Topological polar surface area | 447.3 ร
ยฒcalc.Computed value |
| Hydrogen bond donors | 16calc.Computed value |
| Hydrogen bond acceptors | 14calc.Computed value |
| Rotatable bonds | 32calc.Computed value |
| Heavy atoms | 93calc.Computed value |
| Rings | 8calc.Computed value |
| Aromatic rings | 6calc.Computed value |
| Fraction sp3 carbons | 0.44calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 9calc.Computed value |
| Lipinski rule of five | Fails (3 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C(CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)NCC(=O)N1CCCC1
8 rings, 74 atoms.
23 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H360May damage fertility or the unborn child.
Precautionary statements (5)
- P203Obtain, read and follow all safety instructions before use.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P318If exposed or concerned, get medical advice.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidDeslorelin suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- China, Beijing ManufacturerUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- Spain ManufacturerUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- Hong Kong, Kwun Tong ManufacturerUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- China ManufacturerUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- China, GuangzhouUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- China ManufacturerUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- India ManufacturerUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- United States, Torrance ManufacturerUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- United States ManufacturerUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
- China, NanjingUnclaimed profileDeslorelinGrade, purity and minimum order on requestPrice on request
Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.
Where suppliers are based
21 suppliers in 7 countries
- China9
- United States7
- Spain1
- France1
- Hong Kong1
- India1
- and 1 more countries
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Deslorelin price
Indicative price range per kg from live supplier offers
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Uses and applications
What the substance is used for, by industry and function
Industries and functions
Pharmacological actions
- Enzyme Inhibitors
Pharmacology
Deslorelin is a synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production, in females, prolonged administration results in a decrease in estradiol production. (NCI04)
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- Active ingredient in FDA approved drug labels
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Deslorelin is traded under.
Compounds containing an unfused imidazole ring (whether or not hydrogenated) in theโฆ
- United Kingdom13.0%
- United States7.9%
- China6.5%
* Partner reported figures, a lower bound.
The HS code shown for Deslorelin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Deslorelin, based on the data on this page
What is Deslorelin?
What is the CAS number of Deslorelin?
What is the molecular formula and weight of Deslorelin?
What is Deslorelin used for?
Is Deslorelin hazardous?
What is the HS code of Deslorelin?
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Where can I buy Deslorelin in India?
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Guides for buyers
Practical guides that help when you source, ship or handle Deslorelin
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
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