CompoundList
Sign in
Hormones and steroids

Leuprolide

Also known as Leuprorelin, Leuprorelina, Leuproreline

CAS 53714-56-0Formula C59H84N16O12Molar mass 1,209.42 g/molEC 633-395-9
GHS signal word: Danger. Pictograms: Serious health hazard 55 suppliers listed Drug substance
Get quotes Compare 55 suppliers
Leuprolide chemical structure, C59H84N16O12, CAS 53714-56-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
53714-56-0
Formula
C59H84N16O12
Molar mass
1,209.42 g/mol
Appearance
Fluffy solid
HS code
293719
Category
Hormones and steroids
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Leuprolide?

Plain description, key identifiers and synonyms

Leuprolide is an oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the acetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. It has a role as an antineoplastic agent, an anti-estrogen and a gonadotropin releasing hormone agonist.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CAS number
53714-56-0 CAS number cross-checked
EC number
633-395-9
Molecular formula
C59H84N16O12
UNII
EFY6W0M8TG
MDL number
MFCD00167544
InChIKey
GFIJNRVAKGFPGQ-LIJARHBVSA-N
InChI
InChI=1S/C59H84N16O12/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64)/t40-,41-,42-,43+,44-,45-,46-,47-,48-/m0/s1
Canonical SMILES
CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1
Isomeric SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6

Synonyms

  • Leuprorelin
  • Leuprorelina
  • Leuproreline
  • Leuprorelinum
  • Leuporelin
  • (-)-leuprolide
  • Leuprorelin slow release
  • TAP-144 FREE BASE
  • Abbott-43818 free base
  • pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHC2H5
  • 6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig)
  • 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig)
  • 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
  • Leuprorelin acetate (JAN)
  • Leuprolide acetate (USAN)
  • Leuprolide TFA
  • Leuprolide acetate salt
  • Leuprorelin?
  • Leuprorelin CRS
  • (D-Leu(sup 6),des-gly-NH2(sup 10),pro-ethylamide(sup 9))-GNRH
  • (D-Leu(sup 6),des-gly-NH2(sup 10),pro-ethylamide(sup 9))-LHRH
  • Leuprolide acetate salt, >=98% (HPLC)
  • pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
  • Fensolvi (leuprolide acetate injectable suspension)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Fluffy solidexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,209.42 g/molcalc.
Exact mass
1,208.6455 Dacalc.
LogP (octanol/water)
-1.44calc.
Topological polar surface area
431.5 Ųcalc.
Hydrogen bond donors
15calc.
Hydrogen bond acceptors
14calc.
Rotatable bonds
32calc.
Heavy atoms
87calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.53calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CNC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)NCC(=O)N1CCCC1

O=C(CNC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)NCC(=O)N1CCCC1

6 rings, 64 atoms.

81 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H360May damage fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Leuprolide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 55 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

55 suppliers in 12 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Leuprolide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents, Hormonal
  • Fertility Agents, Female

Roles

  • agonist
  • analgesic
  • anti-HIV agent
  • anti-estrogen
  • anti-obesity agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • gonadotropin releasing hormone agonist
  • hormone agonist
  • hormone receptor modulator
  • pharmaceutical
  • receptor modulator

Pharmacology

Leuprolide is a Gonadotropin Releasing Hormone Receptor Agonist. The mechanism of action of leuprolide is as a Gonadotropin Releasing Hormone Receptor Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Leuprolide is traded under.

HS 2937.19Indicative HS code

Polypeptide hormones, protein hormones and glycoprotein hormones, their derivatives and…

World exports in 2024
$31.5B
+59.6% vs 2023, imports $32.6B
2019 to 2024
Top exporters
  1. Ireland57.3%
  2. United States29.0%
  3. Denmark6.3%
Top importers
  1. United States50.4%
  2. Italy28.1%
  3. Germany7.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Leuprolide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Leuprolide, based on the data on this page

What is Leuprolide?

Leuprolide is an oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-leucyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence.

What is the CAS number of Leuprolide?

The CAS registry number of Leuprolide is 53714-56-0.

What is the molecular formula and weight of Leuprolide?

The molecular formula of Leuprolide is C59H84N16O12 and its molar mass is 1,209.42 g/mol.

What is Leuprolide used for?

Known uses and roles of Leuprolide include anticancer drugs in pharmaceuticals, hormones and steroids in pharmaceuticals, agonist, analgesic, anti-hiv agent and 12 more.

Is Leuprolide hazardous?

Leuprolide carries the GHS signal word "Danger". Main hazards: may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Leuprolide?

Leuprolide is usually classified under HS code 293719 (Polypeptide hormones, protein hormones and glycoprotein hormones, their derivatives and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Leuprolide?

CompoundList lists 55 suppliers of Leuprolide in United States, China, India, Germany and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Leuprolide in India?

4 suppliers in India list Leuprolide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Leuprolide?

Suppliers quote Leuprolide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Leuprolide

Get quotes for Leuprolide

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Leuprolide
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Leuprolide with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/leuprolide-53714-56-0" title="Leuprolide structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Hormones and steroids or HS code 293719

55 suppliers
Free quotes, contact stays private
Get quotes