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Respiratory, allergy and digestive drugs

Dextromethorphan

Also known as d-Methorphan, delta-Methorphan, Dextromorphan

CAS 125-71-3Formula C18H25NOMolar mass 271.40 g/molEC 204-752-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 45 suppliers listed Drug substance
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Dextromethorphan chemical structure, C18H25NO, CAS 125-71-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to slightly yellow crystalline powder
Melting point
109 to 111
Solubility
Practically insoluble in water
HS code
293399
Category
Respiratory, allergy and digestive drugs
Illustrative photo, off-white crystalline powder with an amber glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Dextromethorphan?

Plain description, key identifiers and synonyms

Dextromethorphan is a 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough. It has a role as a oneirogen, a xenobiotic, a prodrug, a neurotoxin, an antitussive, a NMDA receptor antagonist and an environmental contaminant. It is functionally related to a dextrorphan. It is an enantiomer of a levomethorphan.

Dextromethorphan is a morphinan antitussive and dissociative drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
CAS number
125-71-3 CAS number cross-checked
EC number
204-752-2
Molecular formula
C18H25NO
UNII
7355X3ROTS
InChIKey
MKXZASYAUGDDCJ-NJAFHUGGSA-N
InChI
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
Canonical SMILES
COc1ccc2c(c1)C13CCCCC1C(C2)N(C)CC3
Isomeric SMILES
CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC

Synonyms

  • d-Methorphan
  • delta-Methorphan
  • Dextromorphan
  • Dextromethorfan
  • Dextrometorfano
  • Dextromethorphane
  • Albutussin
  • Destrometerfano
  • Dextromethorphanum
  • BA 2666
  • Balminil DM
  • (+)-Dextromethorphan
  • 3-Methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan
  • Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-
  • DXM [Antitussive]
  • (+)-3-Methoxy-N-methylmorphinon
  • DXM (Antitussive)
  • (+)-cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4alpha-iminoethanophenanthren
  • (+)-3-methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan
  • RoboTablets
  • Delsym (dextromethorphan)
  • Soothe Comfort I Cough Syrup
  • Hydrochloride, Dextromethorphan
  • Soothe Comfort II Cough Syrup
  • Soothe Comfort I Cough Syrup Original
Show all 33 synonyms
  • Soothe Comfort II Cough Syrup Herbal Mint
  • LIBI AIR VIRLAZA Dextromethorphan Cough Suppressant
  • (1R,9R,10R)-4-methoxy-17-methyl-17-azatetracyclo(7.5.3.01,10.02,7)heptadeca-2(7),3,5-triene
  • Nodex
  • Dextrometorphan
  • (1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
  • (+)-3-Methoxy-17-methylmorphinan
  • DXM

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to slightly yellow crystalline powderexp.
Odour
Odorlessexp.
Melting point
109 to 111exp.
Solubility
Practically insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
271.40 g/molcalc.
Exact mass
271.1936 Dacalc.
LogP (octanol/water)
3.38calc.
Topological polar surface area
12.47 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
20calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CC1NCCC23CCCCC13

c1ccc2c(c1)CC1NCCC23CCCCC13

4 rings, 17 atoms.

171 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dextromethorphan suppliers

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All 45 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

45 suppliers in 16 countries

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Dextromethorphan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antitussive Agents, Excitatory Amino Acid Antagonists.

Probe to determine cytochrome 450 phenotype.

Dextromethorphan (DXM) is an over-the-counter (OTC) cough suppressant commonly found in cold medications. DXM is often abused in high doses by adolescents to generate euphoria and visual and auditory hallucinations. Illicit use of DXM is referred to on the street as "Robo-tripping" or "skittling." These terms are derived from the most commonly abused products, Robitussin and Coricidin.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antitussive Agents
  • Excitatory Amino Acid Antagonists

Roles

  • NMDA receptor antagonist
  • aetiopathogenetic role
  • antagonist
  • antitussive
  • central nervous system drug
  • environmental contaminant
  • excitatory amino acid antagonist
  • neurotoxin
  • oneirogen
  • pharmaceutical
  • poison
  • pro-agent
  • prodrug
  • psychotropic drug
  • xenobiotic

Functional uses

  • Pharmaceutical

Pharmacology

Dextromethorphan is an Uncompetitive N-methyl-D-aspartate Receptor Antagonist and Sigma-1 Agonist. The mechanism of action of dextromethorphan is as an Uncompetitive NMDA Receptor Antagonist and Sigma-1 Receptor Agonist.

How it is made

Dextromethorphan is made by resolution of (+,-)-3-hydroxy-N-methylmorphinan ... with D-tartaric acid and subsequent O-methylation of the (+)-isomer with phenyltrimethylammonium hydroxide.

Dextromethorphan base (d-3-methoxy-N-methylmorphinan) is prepared from the corresponding d-3-hydroxy compound by methylation with phenyltrimethylammonium hydroxide.

Preparation: O. Schnider, A. Grussner ... United States of America patent 2676177 (1954 to Hoffmann-La Roche).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Dextromethorphan (INN) and its salts, Ref no: 226, Annex ref: II/226
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dextromethorphan is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dextromethorphan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dextromethorphan, based on the data on this page

What is Dextromethorphan?

Dextromethorphan is a 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.

What is the CAS number of Dextromethorphan?

The CAS registry number of Dextromethorphan is 125-71-3.

What is the molecular formula and weight of Dextromethorphan?

The molecular formula of Dextromethorphan is C18H25NO and its molar mass is 271.40 g/mol.

What is Dextromethorphan used for?

Antitussive Agents, Excitatory Amino Acid Antagonists. Probe to determine cytochrome 450 phenotype. Dextromethorphan (DXM) is an over-the-counter (OTC) cough suppressant commonly found in cold medications. DXM is often abused in high doses by adolescents to generate euphoria and visual and auditory hallucinations.

Is Dextromethorphan hazardous?

Dextromethorphan carries the GHS signal word "Danger". Main hazards: toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dextromethorphan?

Dextromethorphan is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dextromethorphan?

CompoundList lists 45 suppliers of Dextromethorphan in India, United States, China, Germany and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dextromethorphan in India?

16 suppliers in India list Dextromethorphan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dextromethorphan?

Suppliers quote Dextromethorphan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dextromethorphan

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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