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Central nervous system drugs

Dibucaine

Also known as Cinchocaine, Nupercainal, Dermacaine

CAS 85-79-0Formula C20H29N3O2Molar mass 343.47 g/molEC 201-632-1
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant 80 suppliers listed Drug substance
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Dibucaine chemical structure, C20H29N3O2, CAS 85-79-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless or almost colorless powder
Melting point
64 °C
Solubility
Hydroscopic crystals, decomp @ 90-98 °C, faintly alkaline to litmus (aq soln, 1 in 20),…
HS code
293349
Category
Central nervous system drugs
Illustrative photo, fine white powder in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Dibucaine?

Plain description, key identifiers and synonyms

Cinchocaine is a monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally only used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions. It has a role as a topical anaesthetic. It is a monocarboxylic acid amide, an aromatic ether and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
CAS number
85-79-0 CAS number cross-checked
EC number
201-632-1
Molecular formula
C20H29N3O2
UNII
L6JW2TJG99
MDL number
MFCD00047595
InChIKey
PUFQVTATUTYEAL-UHFFFAOYSA-N
InChI
InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
SMILES (canonical and isomeric)
CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC

Synonyms

  • Cinchocaine
  • Nupercainal
  • Dermacaine
  • Dibucaine Base
  • Dibucain
  • 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
  • Cinchocainum
  • Cincocaina
  • Cincocainio
  • 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide
  • 2-butoxy-N-(2-(diethylamino)ethyl)quinoline-4-carboxamide
  • Dibucaine (USP)
  • 2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide
  • 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide
  • 2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide
  • N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide
  • alpha-Butyloxycinchoninic acid diethylethylenediamide
  • alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine
  • 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
  • Dibucaine 1%
  • 4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-
  • 2-Butoxy-N-[2-(diethylamino)ethyl]cinchoninamide
  • Cinchoninamide, 2-butoxy-N-(2-(diethylamino)ethyl)-
  • 4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-
  • 2-butoxy-N-(alpha-diethylaminoethyl)cinchoninamide
Show all 37 synonyms
  • 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide
  • N-[2-(Diethylamino)ethyl]-2-butoxycinchoninamide
  • Cinchoninamide, 2-butoxy-N-[2-(diethylamino)ethyl]-
  • 2-Butoxy-N-(2-(diethylamino)ethyl)-4-quinolinecarboxamide
  • 2-butoxy-N-(2-(diethylamino)ethyl)quinoline-4-carboximidic acid
  • 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboximidic acid
  • sovcainum (for the hydrochloride)
  • Cvs Hemorrhoidal Topical Analgesic
  • Dibucaine Topical Anesthetic 1% Hemorrhoidal
  • Nupercaine
  • Sovcaine
  • Percamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless or almost colorless powderexp.
Odour
Odorlessexp.
Melting point
64 °Cexp.
Solubility
Hydroscopic crystals, decomp @ 90-98 °C, faintly alkaline to litmus (aq soln, 1 in 20), freely sol in alc, acetone, chloroform, sol in 0.5 part water, slightly sol in benzene, ethyl acetate, toluene (on warming), insol in ether, oils…exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
343.47 g/molcalc.
Exact mass
343.226 Dacalc.
LogP (octanol/water)
3.49calc.
Topological polar surface area
54.46 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
10calc.
Heavy atoms
25calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2ncccc2c1

c1ccc2ncccc2c1

2 rings, 10 atoms, the Quinoline ring system.

21,766 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H318Causes serious eye damage.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dibucaine suppliers

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All 80 suppliers
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Where suppliers are based

80 suppliers in 16 countries

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Dibucaine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Therapeutic category: Anesthetic (local) (Hydrochloride).

Medicine (anesthetic).

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Anesthetics, Local

Roles

  • anaesthetic
  • local anaesthetic
  • pharmaceutical
  • topical anaesthetic

Pharmacology

Dibucaine is a Standardized Chemical Allergen. The physiologic effect of dibucaine is by means of Increased Histamine Release and Cell-mediated Immunity.

How it is made

Miescher, US patent 1,825,623 (1931 to Ciba). (Dibucaine hydrochloride)

Quinoline derivative

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Cinchocaine (INN) and its salts, Ref no: 129, Annex ref: II/129
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dibucaine is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dibucaine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dibucaine, based on the data on this page

What is Dibucaine?

Cinchocaine is a monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia.

What is the CAS number of Dibucaine?

The CAS registry number of Dibucaine is 85-79-0.

What is the molecular formula and weight of Dibucaine?

The molecular formula of Dibucaine is C20H29N3O2 and its molar mass is 343.47 g/mol.

What is Dibucaine used for?

Veterinary medication:. Therapeutic category: Anesthetic (local) (Hydrochloride). Medicine (anesthetic). Use classes: Pharmaceuticals.

Is Dibucaine hazardous?

Dibucaine carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dibucaine?

Dibucaine is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dibucaine?

CompoundList lists 80 suppliers of Dibucaine in United States, China, India, United Kingdom and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dibucaine in India?

6 suppliers in India list Dibucaine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dibucaine?

Suppliers quote Dibucaine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dibucaine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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