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Cardiovascular and metabolic drugs

Digoxin

Also known as Lanoxin, Dilanacin, Rougoxin

CAS 20830-75-5Formula C41H64O14Molar mass 780.95 g/molEC 244-068-1
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard, Hazardous to the environment 76 suppliers listed Drug substance
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Digoxin chemical structure, C41H64O14, CAS 20830-75-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless to white crystals, or white crystalline powder
Melting point
249 °C
Density
1.36 g/cm³ at 20 °C
Solubility
Cardiac glycosides have a characteristic ring structure known as an aglycone (orgenin) c…
HS code
293220
Category
Cardiovascular and metabolic drugs
UN number
UN 2811
Illustrative photo, off-white powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Digoxin?

Plain description, key identifiers and synonyms

Digoxin is a cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small. It has a role as an anti-arrhythmia drug, a cardiotonic drug, an epitope and an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a cardenolide glycoside and a steroid saponin. It is a conjugate acid of a digoxin(1-).

Digoxin is a plant-derived medication used in certain heart conditions.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
CAS number
20830-75-5 CAS number cross-checked
EC number
244-068-1
Molecular formula
C41H64O14
UNII
73K4184T59
MDL number
MFCD00003674
InChIKey
LTMHDMANZUZIPE-PUGKRICDSA-N
InChI
InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1
Canonical SMILES
CC1OC(OC2C(O)CC(OC3C(O)CC(OC4CCC5(C)C(CCC6C5CC(O)C5(C)C(C7=CC(=O)OC7)CCC65O)C4)OC3C)OC2C)CC(O)C1O
Isomeric SMILES
C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O

Synonyms

  • Lanoxin
  • Dilanacin
  • Rougoxin
  • Digacin
  • Digosin
  • Dynamos
  • Vanoxin
  • 12beta-Hydroxydigitoxin
  • Digoxine
  • Fargoxin
  • Lanoxicaps
  • Mapluxin
  • Natigoxin
  • Davoxin
  • Cardiogoxin
  • Cordioxil
  • Digoxina
  • Digoxinum
  • Eudigox
  • Lanacrist
  • Lanocardin
  • Toloxin
  • Stillacor-
  • Neo-Lanicor
  • Digoxin Pediatric
Show all 39 synonyms
  • SK-Digoxin
  • Homolle's digitalin
  • Lanacordin
  • Acygoxin
  • Cardioxin
  • Digoksyna
  • Digonix
  • Digossina
  • Saroxin
  • Dixina
  • Lanoxin PG
  • Cardoxin
  • Chloroformic digitalin
  • Lanoxin pediatric

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless to white crystals, or white crystalline powderexp.
Odour
Odorlessexp.
Taste
Bitterexp.
Melting point
249 °Cexp.
Density
1.36 g/cm³ at 20 °Cexp.
Solubility
Cardiac glycosides have a characteristic ring structure known as an aglycone (orgenin) coupled with one or more types of sugars.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
780.95 g/molcalc.
Exact mass
780.4296 Dacalc.
LogP (octanol/water)
2.22calc.
Topological polar surface area
203.1 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
14calc.
Rotatable bonds
7calc.
Heavy atoms
55calc.
Rings
8calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.93calc.
Formal charge
0calc.
Stereocentres
21calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C(C2CCC3C2CCC2C4CCC(OC5CCC(OC6CCC(OC7CCCCO7)CO6)CO5)CC4CCC23)CO1

O=C1C=C(C2CCC3C2CCC2C4CCC(OC5CCC(OC6CCC(OC7CCCCO7)CO6)CO5)CC4CCC23)CO1

8 rings, 44 atoms.

55 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300 + H330Fatal if swallowed. Fatal if inhaled.
  • H300Fatal if swallowed.
  • H319Causes serious eye irritation.
  • H330Fatal if inhaled.
  • H331Toxic if inhaled.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
Precautionary statements (22)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P319Get medical help if you feel unwell.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Digoxin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 76 suppliers
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Where suppliers are based

76 suppliers in 20 countries

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Digoxin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Anti-Arrhythmia Agents, Cardiotonic Agents, Enzyme Inhibitors.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Cardiotonic Agents
  • Enzyme Inhibitors

Roles

  • analgesic
  • anti-HBV agent
  • anti-HIV agent
  • anti-arrhythmia drug
  • anti-inflammatory agent
  • anti-obesity agent
  • anticonvulsant
  • antidepressant
  • antiemetic
  • antihypertensive agent
  • antiinfective agent
  • antimicrobial agent
  • antineoplastic agent
  • antirheumatic drug
  • antiviral agent
  • cardiotonic drug
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • enzyme inhibitor
  • epitope
  • hypoglycemic agent
  • pharmaceutical
  • psychotropic drug

Pharmacology

Digoxin is a Cardiac Glycoside.

How it is made

From the leaves of Digitalis lanata.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Digoxin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Digoxin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Digoxin, based on the data on this page

What is Digoxin?

Digoxin is a cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic…

What is the CAS number of Digoxin?

The CAS registry number of Digoxin is 20830-75-5.

What is the molecular formula and weight of Digoxin?

The molecular formula of Digoxin is C41H64O14 and its molar mass is 780.95 g/mol.

What is Digoxin used for?

Veterinary medication:. Anti-Arrhythmia Agents, Cardiotonic Agents, Enzyme Inhibitors. Use classes: Pharmaceuticals.

Is Digoxin hazardous?

Digoxin carries the GHS signal word "Danger". Main hazards: fatal if swallowed. fatal if inhaled, fatal if swallowed, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Digoxin?

Digoxin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Digoxin?

CompoundList lists 76 suppliers of Digoxin in United States, China, India, United Kingdom and 16 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Digoxin in India?

10 suppliers in India list Digoxin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Digoxin?

Suppliers quote Digoxin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Digoxin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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