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Screening compounds

Dihydroetorphine

Also known as 18,19-Dihydroetorphine, Tetrahydro-7alpha-(1-hydroxy-1-methylbutyl)-6,14-endo-ethanooripavine, (1S,2R,6S,14R,15R,16R)-16-((2R)-2-hydroxypentan-2-yl)-15-methoxy-3-methyl-13-oxa-3-azahexacyclo(13.2.2.12,?.01,?.0?,1?.0?,12)icosa-7,9,11-trien-11-ol

CAS 14357-76-7Formula C25H35NO4Molar mass 413.56 g/molEC 688-180-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard
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Dihydroetorphine chemical structure, C25H35NO4, CAS 14357-76-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
14357-76-7
Formula
C25H35NO4
Molar mass
413.56 g/mol
EC number
688-180-2
HS code
293499
Category
Screening compounds

What is Dihydroetorphine?

Plain description, key identifiers and synonyms

Dihydroetorphine is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,2S,6R,14R,15R,16R)-16-[(2R)-2-hydroxypentan-2-yl]-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
CAS number
14357-76-7 CAS number cross-checked
EC number
688-180-2
Molecular formula
C25H35NO4
UNII
QQX8S479YV
InChIKey
BRTSNYPDACNMIP-FAWZKKEFSA-N
InChI
InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1
Canonical SMILES
CCCC(C)(O)C1CC23CCC1(OC)C1Oc4c(O)ccc5c4C12CCN(C)C3C5
Isomeric SMILES
CCC[C@](C)([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)O)O4)C)OC)O

Synonyms

  • 18,19-Dihydroetorphine
  • Tetrahydro-7alpha-(1-hydroxy-1-methylbutyl)-6,14-endo-ethanooripavine
  • (1S,2R,6S,14R,15R,16R)-16-((2R)-2-hydroxypentan-2-yl)-15-methoxy-3-methyl-13-oxa-3-azahexacyclo(13.2.2.12,?.01,?.0?,1?.0?,12)icosa-7,9,11-trien-11-ol
  • 7,8-Dihydro-7alpha-(1-(R)-hydroxy-1-methylbutyl)-6,14-endo-ethanotetrahydrooripavine
  • R-dihydroetorphine
  • 7,8-Dihydro-7alpha-[1-(R)-hydroxy-1-methylbutyl]-6,14-endo-ethanotetrahydrooripavine
  • DEA No. 9334
  • PDSP2_001434
  • 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-, (5alpha,7alpha(R))-
  • 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-, (alphaR,5alpha,7alpha)-
  • (18R)-18-[(2R)-2-Hydroxypentan-2-yl]-6-methoxy-17-methyl-5alpha,6beta,14beta-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
  • 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-propyl-, (.alpha.r,5alpha,7.alpha.)
  • 7,8-Dihydro-7alpha-(1-(R)-hydroxy-1-methylbutyl)-6,14-endoethanotetrahydrooripavine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
413.56 g/molcalc.
Exact mass
413.2566 Dacalc.
LogP (octanol/water)
3.39calc.
Topological polar surface area
62.16 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
30calc.
Rings
7calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.76calc.
Formal charge
0calc.
Stereocentres
7calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc2c3c(c1)OC1C4CCC5(CC4)C(C2)NCCC315

c1cc2c3c(c1)OC1C4CCC5(CC4)C(C2)NCCC315

7 rings, 20 atoms.

23 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H330Fatal if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (17)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dihydroetorphine suppliers

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Dihydroetorphine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Analgesics, Opioid

Regulatory status

Inventories, regulations and trade controls that list this substance

Controls

  • US DEA controlled substance or listed chemical

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dihydroetorphine is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Dihydroetorphine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dihydroetorphine, based on the data on this page

What is Dihydroetorphine?

Dihydroetorphine is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.

What is the CAS number of Dihydroetorphine?

The CAS registry number of Dihydroetorphine is 14357-76-7.

What is the molecular formula and weight of Dihydroetorphine?

The molecular formula of Dihydroetorphine is C25H35NO4 and its molar mass is 413.56 g/mol.

What is Dihydroetorphine used for?

Known uses and roles of Dihydroetorphine include building blocks in research and laboratory, screening compounds in research and laboratory and analgesics, opioid.

Is Dihydroetorphine hazardous?

Dihydroetorphine carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal if inhaled, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dihydroetorphine?

Dihydroetorphine is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dihydroetorphine?

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What is the price of Dihydroetorphine?

Suppliers quote Dihydroetorphine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dihydroetorphine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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