CompoundList
Sign in
Cardiovascular and metabolic drugs

Diltiazem

Also known as d-cis-Diltiazem, Dilcontin, Dilticard

CAS 42399-41-7Formula C22H26N2O4SMolar mass 414.53 g/molEC 255-796-4
54 suppliers listed Drug substance
Get quotes Compare 54 suppliers
Diltiazem chemical structure, C22H26N2O4S, CAS 42399-41-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White crystalline powder
Melting point
212 °C
Boiling point
Decomposes
Solubility
Soluble in methanol or chloroform
HS code
293499
Category
Cardiovascular and metabolic drugs
Illustrative photo, off-white crystalline powder with an amber glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Diltiazem?

Plain description, key identifiers and synonyms

Diltiazem is a 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension. It has a role as a vasodilator agent, an antihypertensive agent and a calcium channel blocker. It is a conjugate base of a diltiazem(1+). It is an enantiomer of an ent-diltiazem.

Diltiazem is a nondihydropyridine (non-DHP) calcium channel blocker used in the treatment of hypertension, angina pectoris, and some types of arrhythmia.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
CAS number
42399-41-7Other or deprecated CAS: 56209-45-1, 75472-92-3
EC numbers
255-796-4, 260-060-0
Molecular formula
C22H26N2O4S
UNII
EE92BBP03H
MDL number
MFCD00868239
InChIKey
HSUGRBWQSSZJOP-RTWAWAEBSA-N
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
Canonical SMILES
COc1ccc(C2Sc3ccccc3N(CCN(C)C)C(=O)C2OC(C)=O)cc1
Isomeric SMILES
CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC

Synonyms

  • d-cis-Diltiazem
  • Dilcontin
  • Dilticard
  • Acalix
  • Anoheal
  • Incoril AP
  • Diltiazemum
  • Surazem
  • Dilacor-XR
  • (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
  • Herbesser
  • Ditiaz
  • Diltiazem extended release
  • Diltia XT
  • (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
  • [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
  • Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
  • (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
  • (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
  • ((2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl) acetate
  • (+)-cis-5-(2-(dimethylamino)ethyl)-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
  • (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
  • (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo(b)(1,4)thiazepin-3-yl acetate
  • (2S-cis)-3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Show all 38 synonyms
  • Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo(b)(1,4)thiazepin-3-yl ester
  • Cardizem
  • (+)-diltiazem
  • Cardil
  • Dilren
  • (+)-cis-diltiazem
  • Dilt-cd
  • Diltiazem free base
  • Diltiazem (INN)
  • Endrydil
  • Dilzen
  • [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
  • Dilta-Hexal

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White crystalline powderexp.
Melting point
212 °Cexp.
Boiling point
Decomposesexp.
Solubility
Soluble in methanol or chloroformexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
414.53 g/molcalc.
Exact mass
414.1613 Dacalc.
LogP (octanol/water)
3.37calc.
Topological polar surface area
59.08 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
6calc.
Heavy atoms
29calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC(c2ccccc2)Sc2ccccc2N1

O=C1CC(c2ccccc2)Sc2ccccc2N1

3 rings, 18 atoms, the 2-Phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one ring system.

122 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Diltiazem suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 54 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

54 suppliers in 13 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Diltiazem price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antihypertensive Agents
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Vasodilator Agents

Roles

  • antagonist
  • anti-arrhythmia drug
  • antiatherosclerotic agent
  • anticoagulant
  • antihypertensive agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • biophysical role
  • calcium channel blocker
  • calcium channel modulator
  • cardiovascular drug
  • hematologic agent
  • hypoglycemic agent
  • laxative
  • membrane transport modulator
  • pharmaceutical
  • vasodilator agent

Functional uses

  • Pharmaceutical

Pharmacology

Diltiazem is a Calcium Channel Blocker. The mechanism of action of diltiazem is as a Calcium Channel Antagonist and Cytochrome P450 3A4 Inhibitor.

How it is made

P-Anisaldehyde + methyl chloroacetate + 2-aminothiophenol + acetic anhydride + 2-dimethylaminoethyl chloride hydrochloride (Darzens reaction/epoxidation/saponification/racemate separation/condensation/amine formation)

Prepn (unspec stereochem): H. Kugita et al., DE 1805714, eidem, US 3562257 (1969, 1971 both to Tanabe Seiyaku), eidem, Chem. Pharm. Bull. 19, 595 (1971). ...Stereospecific synthesis: K. Igarashi, T. Honma, DE 3415035, eidem, US 4552695 (1984, 1985 both to Shionogi)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diltiazem is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Diltiazem is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diltiazem, based on the data on this page

What is Diltiazem?

Diltiazem is a 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.

What is the CAS number of Diltiazem?

The CAS registry number of Diltiazem is 42399-41-7. Other or deprecated CAS numbers: 56209-45-1, 75472-92-3.

What is the molecular formula and weight of Diltiazem?

The molecular formula of Diltiazem is C22H26N2O4S and its molar mass is 414.53 g/mol.

What is Diltiazem used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Diltiazem hazardous?

No GHS hazard classification for Diltiazem is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Diltiazem?

Diltiazem is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diltiazem?

CompoundList lists 54 suppliers of Diltiazem in United States, China, Spain, Germany and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diltiazem in India?

2 suppliers in India list Diltiazem on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diltiazem?

Suppliers quote Diltiazem on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diltiazem

Get quotes for Diltiazem

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Diltiazem
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Diltiazem with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/diltiazem-42399-41-7" title="Diltiazem structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Cardiovascular and metabolic drugs or HS code 293499

54 suppliers
Free quotes, contact stays private
Get quotes