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Murcko scaffold

2-Phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one scaffold

123 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
123
With full pages
27
Scaffold SMILES

O=C1CC(c2ccccc2)Sc2ccccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one page
Murcko scaffold O=C1CC(c2ccccc2)Sc2ccccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 123 chemicals

3-(Acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one chemical structure, C22H26N2O4S, CAS 34933-06-7
3-(Acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
CAS 34933-06-7C22H26N2O4S
5-(2-(Dimethylamino)ethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one chemical structure, C19H22N2OS, CAS 5845-26-1
5-(2-(Dimethylamino)ethyl)-2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one
CAS 5845-26-1C19H22N2OS
Diltiazem chemical structure, C22H26N2O4S, CAS 42399-41-7
Diltiazem
CAS 42399-41-7C22H26N2O4S
Clentiazem chemical structure, C22H25ClN2O4S, CAS 96125-53-0
Clentiazem
CAS 96125-53-0C22H25ClN2O4S
Diltiazem hydrochloride chemical structure, C22H27ClN2O4S, CAS 33286-22-5
Diltiazem hydrochloride
CAS 33286-22-5C22H27ClN2O4S
Siratiazem chemical structure, C24H30N2O4S, CAS 138778-28-6
Siratiazem
CAS 138778-28-6C24H30N2O4S
Thiazesim hydrochloride chemical structure, C19H23ClN2OS, CAS 3122-01-8
Thiazesim hydrochloride
CAS 3122-01-8C19H23ClN2OS
Deacetyldiltiazem chemical structure, C20H24N2O3S, CAS 42399-40-6
Deacetyldiltiazem
CAS 42399-40-6C20H24N2O3S
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)- chemical structure, C22H25ClN2O4S, CAS 111659-76-8
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-
CAS 111659-76-8C22H25ClN2O4S
N-Demethyldiltiazem chemical structure, C21H24N2O4S, CAS 86408-45-9
N-Demethyldiltiazem
CAS 86408-45-9C21H24N2O4S
TA 993 chemical structure, C23H28N2O3S, CAS 122024-96-8
TA 993
CAS 122024-96-8C23H28N2O3S
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-(2-(methylamino)ethyl)-, (2S,3S)- chemical structure, C19H22N2O3S, CAS 86408-44-8
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-(2-(methylamino)ethyl)-, (2S,3S)-
CAS 86408-44-8C19H22N2O3S
Deacetyl-N-monodemethyldiltiazem chemical structure, C19H23ClN2O3S, CAS 40861-80-1
Deacetyl-N-monodemethyldiltiazem
CAS 40861-80-1C19H23ClN2O3S
O-Desacetyl-N-desmethyl Diltiazem chemical structure, C19H22N2O3S, CAS 81353-09-5
O-Desacetyl-N-desmethyl Diltiazem
CAS 81353-09-5C19H22N2O3S
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2R,3R)- chemical structure, C22H27ClN2O4S, CAS 42399-54-2
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2R,3R)-
CAS 42399-54-2C22H27ClN2O4S
L-(Cis)-diltiazem chemical structure, C22H26N2O4S, CAS 56209-45-1
L-(Cis)-diltiazem
CAS 56209-45-1C22H26N2O4S
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1) chemical structure, C22H27ClN2O4S, CAS 23515-59-5
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1)
CAS 23515-59-5C22H27ClN2O4S
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-5-(2-(dimethylamino)ethyl)-3-hydroxy-2-(p-methoxyphenyl)-, monohydrochloride, (Z)- chemical structure, C20H25ClN2O3S, CAS 40601-99-8
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-5-(2-(dimethylamino)ethyl)-3-hydroxy-2-(p-methoxyphenyl)-, monohydrochloride, (Z)-
CAS 40601-99-8C20H25ClN2O3S
Cpd7L38xbp chemical structure, C20H24N2O3S, CAS 42399-39-3
Cpd7L38xbp
CAS 42399-39-3C20H24N2O3S
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-5-(2-(dimethylamino)ethyl)-3-hydroxy-2-(p-hydroxphenyl)-, monohydrochloride chemical structure, C19H23ClN2O3S, CAS 40602-08-2
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-5-(2-(dimethylamino)ethyl)-3-hydroxy-2-(p-hydroxphenyl)-, monohydrochloride
CAS 40602-08-2C19H23ClN2O3S
5-[2-(Dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one chemical structure, C19H22N2O3S, CAS 33286-23-6
5-[2-(Dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-hydroxyphenyl)-1,5-benzothiazepin-4(5H)-one
CAS 33286-23-6C19H22N2O3S
2-Phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one chemical structure, C15H13NOS, CAS 29476-22-0
2-Phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one
CAS 29476-22-0C15H13NOS
2-(3-Chlorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one chemical structure, C15H12ClNOS, CAS 361375-26-0
2-(3-Chlorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
CAS 361375-26-0C15H12ClNOS
Bas 09588626 chemical structure, C18H19NO4S, CAS 89813-62-7
Bas 09588626
CAS 89813-62-7C18H19NO4S