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Carbohydrates and sugars

Dimethyl isosorbide

Also known as Isosorbide dimethyl ether, 2,5-Dimethylisosorbide, 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol

CAS 5306-85-4Formula C8H14O4Molar mass 174.20 g/molEC 226-159-8
21 suppliers listed
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Dimethyl isosorbide chemical structure, C8H14O4, CAS 5306-85-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
5306-85-4
Formula
C8H14O4
Molar mass
174.20 g/mol
Physical form
Liquid
HS code
294000
Category
Carbohydrates and sugars
Illustrative photo, closed blue jerry cans in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Dimethyl isosorbide?

Plain description, key identifiers and synonyms

Dimethyl isosorbide is a chemical substance with the molecular formula C8H14O4 and a molar mass of 174.20 g/mol. Its CAS registry number is 5306-85-4. The IUPAC name is (3S,3aR,6R,6aR)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S,3aR,6R,6aR)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan
CAS number
5306-85-4 CAS number cross-checked
EC number
226-159-8
Molecular formula
C8H14O4
UNII
SA6A6V432S
MDL number
MFCD00064828
INCI name
DIMETHYL ISOSORBIDE
InChIKey
MEJYDZQQVZJMPP-ULAWRXDQSA-N
InChI
InChI=1S/C8H14O4/c1-9-5-3-11-8-6(10-2)4-12-7(5)8/h5-8H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1
Canonical SMILES
COC1COC2C(OC)COC12
Isomeric SMILES
CO[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2OC

Synonyms

  • Isosorbide dimethyl ether
  • 2,5-Dimethylisosorbide
  • 1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol
  • D-Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-
  • 2,5-O-dimethylisosorbide
  • Arlasolve DMI
  • (3R,3aR,6S,6aR)-3,6-Dimethoxyhexahydrofuro[3,2-b]furan
  • (3S,3aR,6R,6aR)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan
  • 2,5-Di-O-methyl-1,4:3,6-dianhydro-D-glucitol
  • (3R,3aR,6S,6aR)-3,6-dimethoxy-hexahydrofuro[3,2-b]furan
  • dimethyl isosorbide ether
  • dimethyl isosorbide, ResCo
  • 1,4:3,6-Dianhydrosorbitol 2,5-dimethyl ether
  • Dimethyl isosorb ide
  • Isosorbide, dimethyl ether
  • Sorbitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-
  • Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl-, D-
  • Isosorbide dimethyl ether, 98%
  • D-Glucitol, 1,4:3,6-dianhydro-2,5-di-O-methyl
  • (4S,1R,5R,8R)-4,8-dimethoxy-2,6-dioxabicyclo[3.3.0]octane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Liquidexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
174.20 g/molcalc.
Exact mass
174.0892 Dacalc.
LogP (octanol/water)
-0.19calc.
Topological polar surface area
36.92 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
12calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CC2OCCC2O1

C1CC2OCCC2O1

2 rings, 8 atoms, the 1,4:3,6-Dianhydro-2,5-dideoxyhexitol ring system.

149 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Dimethyl isosorbide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 21 suppliers
21 of 21 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

21 suppliers in 5 countries

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Dimethyl isosorbide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industrial uses: Solvent, Stabilizing agent.

Consumer uses: Surfactant (surface active agent), Solvent.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name DIMETHYL ISOSORBIDE(solvent, viscosity controlling)

Functional uses

  • Solvent
  • Viscosity modifier

Cosmetic functions

  • Solvent
  • Viscosity controlling

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Added by a premanufacture notice

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dimethyl isosorbide is traded under.

HS 2940.00Indicative HS code

Sugar ethers, sugar acetals and sugar esters, and their salts, other than the products of heading 29.37…

World exports in 2024
$1.4B
−5.4% vs 2023, imports $1.42B
2019 to 2024
Top exporters
  1. Germany23.7%
  2. China20.6%
  3. United States11.5%
Top importers
  1. United States14.0%
  2. Japan7.4%
  3. Germany6.1%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Dimethyl isosorbide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dimethyl isosorbide, based on the data on this page

What is Dimethyl isosorbide?

Dimethyl isosorbide is a chemical substance with the molecular formula C8H14O4 and a molar mass of 174.20 g/mol. Its CAS registry number is 5306-85-4. The IUPAC name is (3S,3aR,6R,6aR)-3,6-dimethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan.

What is the CAS number of Dimethyl isosorbide?

The CAS registry number of Dimethyl isosorbide is 5306-85-4.

What is the molecular formula and weight of Dimethyl isosorbide?

The molecular formula of Dimethyl isosorbide is C8H14O4 and its molar mass is 174.20 g/mol.

What is Dimethyl isosorbide used for?

Industrial uses: Solvent, Stabilizing agent. Consumer uses: Surfactant (surface active agent), Solvent. Use classes: Cosmetics.

Is Dimethyl isosorbide hazardous?

No GHS hazard classification for Dimethyl isosorbide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Dimethyl isosorbide?

Dimethyl isosorbide is usually classified under HS code 294000 (Sugars, chemically pure, other than sucrose, lactose, maltose, glucose and fructose…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dimethyl isosorbide?

CompoundList lists 21 suppliers of Dimethyl isosorbide in China, United States, India, Australia and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dimethyl isosorbide in India?

4 suppliers in India list Dimethyl isosorbide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dimethyl isosorbide?

Suppliers quote Dimethyl isosorbide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dimethyl isosorbide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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