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Impurities and reference standards

Dodecamethylpentasiloxane

Also known as 1,1,1,3,3,5,5,7,7,9,9,9-Dodecamethylpentasiloxane, Pentasiloxane, dodecamethyl-, Pentasiloxane, 1,1,1,3,3,5,5,7,7,9,9,9-dodecamethyl-

CAS 141-63-9Formula C12H36O4Si5Molar mass 384.85 g/molEC 205-492-2
GHS signal word: Warning. Pictograms: Harmful or irritant 9 suppliers listed
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Dodecamethylpentasiloxane chemical structure, C12H36O4Si5, CAS 141-63-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid
Melting point
-80 °C
Boiling point
230 °C
Density
0.8755 g/cm³ at 20 °C
Solubility
In water, 7.04 × 10⁻⁵ mg/L at 25 °C
HS code
293190
Category
Impurities and reference standards
Illustrative photo, clear liquid in sealed glass ampoules on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Dodecamethylpentasiloxane?

Plain description, key identifiers and synonyms

Dodecamethylpentasiloxane is an organosiloxane that is pentasiloxane in which all the hydrogens have been replaced by methyl groups. Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
bis[[dimethyl(trimethylsilyloxy)silyl]oxy]-dimethylsilane
CAS number
141-63-9 CAS number cross-checked
EC number
205-492-2
Molecular formula
C12H36O4Si5
UNII
0QDQ2VQ5YJ
MDL number
MFCD00039795
INCI name
PENTASILOXANE
InChIKey
FBZANXDWQAVSTQ-UHFFFAOYSA-N
InChI
InChI=1S/C12H36O4Si5/c1-17(2,3)13-19(7,8)15-21(11,12)16-20(9,10)14-18(4,5)6/h1-12H3
SMILES (canonical and isomeric)
C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C

Synonyms

  • 1,1,1,3,3,5,5,7,7,9,9,9-Dodecamethylpentasiloxane
  • Pentasiloxane, dodecamethyl-
  • Pentasiloxane, 1,1,1,3,3,5,5,7,7,9,9,9-dodecamethyl-
  • Pentasiloxane, dodecamethyl
  • 4-04-00-04124 (Beilstein Handbook Reference)
  • Silicone liquid
  • 1,1,1,3,3,5,5,7,7,9,9,9Dodecamethylpentasiloxane
  • Pentasiloxane, 1,1,1,3,3,5,5,7,7,9,9,9dodecamethyl
  • bis[[dimethyl(trimethylsilyloxy)silyl]oxy]-dimethylsilane
  • Simethicone Impurity 8
  • dodecamethyl pentasiloxane
  • Dodecamethylpentasiloxane, 97%
  • bis[[dimethyl(trimethylsilyloxy)silyl]oxy]-dimethyl-silane
  • Pentasiloxane,1,1,1,3,3,5,5,7,7,9,9,9-dodecamethyl-
  • bis[[dimethyl(trimethylsilyloxy)sil
  • 2,2,4,4,6,6,8,8,10,10-decamethyl-3,5,7,9-tetraoxa-2,4,6,8,10-pentasilaundecane
  • 1,1,1,3,3,5,5,7,7,9,9,9-Dodecamethylpentasiloxane #
  • MD3M, 1,1,1,3,3,5,5,7,7,9,9,9-Dodecamethylpentasiloxane

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Melting point
-80 °Cexp.
Boiling point
230 °Cexp.
Density
0.8755 g/cm³ at 20 °Cexp.
Solubility
In water, 7.04 × 10⁻⁵ mg/L at 25 °Cexp.
Vapour pressure
4.50 × 10⁻² mm Hg at 25 °C (extrapolated)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
384.85 g/molcalc.
Exact mass
384.146 Dacalc.
LogP (octanol/water)
4.83calc.
Topological polar surface area
36.92 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
8calc.
Heavy atoms
21calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (17)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dodecamethylpentasiloxane suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 9 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 4 countries

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Dodecamethylpentasiloxane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

As a basis for silicone oils or fluids designed to withstand extremes of temperature, as a foam suppressant in petroleum lubricating oil.

Industrial uses: Diluent, Intermediate, Other, Solvent, Heat transferring agent.

Consumer uses: Diluent, Lubricating agent.

Cosmetic ingredient, INCI name PENTASILOXANE(antifoaming)

Roles

  • animal metabolite
  • eukaryotic metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite

Cosmetic functions

  • Antifoaming

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dodecamethylpentasiloxane is traded under.

HS 2931.90Indicative HS code

Organo-inorganic compounds, other than tetramethyl lead, tetraethyl lead, tributyltin compounds…

World exports in 2024
$3.97B
+5.3% vs 2023, imports $3.93B
2019 to 2024
Top exporters
  1. China28.3%
  2. United States15.6%
  3. Germany15.1%
Top importers
  1. United States14.6%
  2. China13.0%
  3. South Korea8.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Dodecamethylpentasiloxane is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dodecamethylpentasiloxane, based on the data on this page

What is Dodecamethylpentasiloxane?

Dodecamethylpentasiloxane is an organosiloxane that is pentasiloxane in which all the hydrogens have been replaced by methyl groups. Metabolite observed in cancer metabolism. It has a role as a human metabolite.

What is the CAS number of Dodecamethylpentasiloxane?

The CAS registry number of Dodecamethylpentasiloxane is 141-63-9.

What is the molecular formula and weight of Dodecamethylpentasiloxane?

The molecular formula of Dodecamethylpentasiloxane is C12H36O4Si5 and its molar mass is 384.85 g/mol.

What is Dodecamethylpentasiloxane used for?

As a basis for silicone oils or fluids designed to withstand extremes of temperature, as a foam suppressant in petroleum lubricating oil. Industrial uses: Diluent, Intermediate, Other, Solvent, Heat transferring agent. Consumer uses: Diluent, Lubricating agent.

Is Dodecamethylpentasiloxane hazardous?

Dodecamethylpentasiloxane carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dodecamethylpentasiloxane?

Dodecamethylpentasiloxane is usually classified under HS code 293190 (X. ORGANO-INORGANIC COMPOUNDS, HETEROCYCLIC COMPOUNDS, NUCLEIC ACIDS AND THEIR SALTS…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dodecamethylpentasiloxane?

CompoundList lists 9 suppliers of Dodecamethylpentasiloxane in China, United States, United Kingdom and Japan. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Dodecamethylpentasiloxane?

Suppliers quote Dodecamethylpentasiloxane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dodecamethylpentasiloxane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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