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Screening compounds

Dorsomorphin

Also known as AMPK Inhibitor, Compound C, compound C dorsomorphin, 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine

CAS 866405-64-3Formula C24H25N5OMolar mass 399.50 g/molEC 635-949-5
GHS signal word: Warning. Pictograms: Harmful or irritant 38 suppliers listed
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Dorsomorphin chemical structure, C24H25N5O, CAS 866405-64-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
866405-64-3
Formula
C24H25N5O
Molar mass
399.50 g/mol
EC number
635-949-5
HS code
293359
Category
Screening compounds

What is Dorsomorphin?

Plain description, key identifiers and synonyms

Dorsomorphin is a pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling. It has a role as an EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor and a bone morphogenetic protein receptor antagonist. It is a member of piperidines, a member of pyridines, an aromatic ether and a pyrazolopyrimidine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
CAS number
866405-64-3 CAS number cross-checked
EC number
635-949-5
Molecular formula
C24H25N5O
UNII
10K52CIC1Z
MDL number
MFCD08705402
InChIKey
XHBVYDAKJHETMP-UHFFFAOYSA-N
InChI
InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
SMILES (canonical and isomeric)
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

Synonyms

  • AMPK Inhibitor, Compound C
  • compound C dorsomorphin
  • 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine
  • (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine
  • 6-(4-(2-(1-Piperidinyl)ethoxy)phenyl)-3-(4-pyridinyl)pyrazolo(1,5-a)pyrimidine
  • Pyrazolo(1,5-a)pyrimidine, 6-(4-(2-(1-piperidinyl)ethoxy)phenyl)-3-(4-pyridinyl)-
  • 4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)pyridine
  • 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine
  • Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-
  • 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
  • Compound C
  • 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
  • Dorsomorphin free base
  • Dorsomorphin, >=98% (HPLC)
  • 6-[4-[2-(1-piperidyl)ethoxy]phenyl]-3-(4-pyridyl)pyrazolo[1,5-a]pyrimidine
  • 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
  • 866405-64-3 (free base)
  • AMPK Inhibitor
  • 6-[4-[2-(Piperidin-1-yl)ethoxy]phenyl]-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
  • BML-275 free base
  • BML-275,Compound C
  • Dorsomorphin (BML275)
  • Dorsomorphin(BML-275)
  • Dorsomorphin (Compound C)
  • Dorsomorphin(BML-275)?
Show all 29 synonyms
  • Sdccgsbi-0086732.p003
  • 4-(6-{4-[2-(Piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-alpha]pyrimidin-3-yl)pyridine
  • 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine
  • 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
399.50 g/molcalc.
Exact mass
399.2059 Dacalc.
LogP (octanol/water)
4.32calc.
Topological polar surface area
55.55 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
6calc.
Heavy atoms
30calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1

c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1

5 rings, 30 atoms. This chemical is the scaffold itself.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
Precautionary statements (13)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dorsomorphin suppliers

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All 38 suppliers
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Where suppliers are based

38 suppliers in 5 countries

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Dorsomorphin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Protein Kinase Inhibitors

Roles

  • antagonist
  • bone morphogenetic protein receptor antagonist
  • enzyme inhibitor
  • protein kinase inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dorsomorphin is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dorsomorphin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dorsomorphin, based on the data on this page

What is Dorsomorphin?

Dorsomorphin is a pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively.

What is the CAS number of Dorsomorphin?

The CAS registry number of Dorsomorphin is 866405-64-3.

What is the molecular formula and weight of Dorsomorphin?

The molecular formula of Dorsomorphin is C24H25N5O and its molar mass is 399.50 g/mol.

What is Dorsomorphin used for?

Known uses and roles of Dorsomorphin include building blocks in research and laboratory, screening compounds in research and laboratory, biochemical and pharmacological tools in research and laboratory, antagonist, bone morphogenetic protein receptor antagonist and 3 more.

Is Dorsomorphin hazardous?

Dorsomorphin carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dorsomorphin?

Dorsomorphin is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dorsomorphin?

CompoundList lists 38 suppliers of Dorsomorphin in China, United States, Canada, France and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Dorsomorphin?

Suppliers quote Dorsomorphin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dorsomorphin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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