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Central nervous system drugs

Doxapram

Also known as Doxapramum, Docatone, 2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-

CAS 309-29-5Formula C24H30N2O2Molar mass 378.52 g/molEC 206-216-3
GHS signal word: Warning. Pictograms: Harmful or irritant 66 suppliers listed Drug substance
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Doxapram chemical structure, C24H30N2O2, CAS 309-29-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
309-29-5
Formula
C24H30N2O2
Melting point
123 to 124
Solubility
WHITE TO OFF-WHITE CRYSTALLINE POWDER, PRACTICALLY INSOL IN ETHER /HYDROCHLORIDE/
HS code
293499
Category
Central nervous system drugs

What is Doxapram?

Plain description, key identifiers and synonyms

Doxapram is a member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering. It has a role as a central nervous system stimulant. It is a member of morpholines and a member of pyrrolidin-2-ones.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one
CAS number
309-29-5 CAS number cross-checked
EC number
206-216-3
Molecular formula
C24H30N2O2
UNII
94F3830Q73
MDL number
MFCD00242721
InChIKey
XFDJYSQDBULQSI-UHFFFAOYSA-N
InChI
InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
SMILES (canonical and isomeric)
CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4

Synonyms

  • Doxapramum
  • Docatone
  • 2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-
  • 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
  • (+-)-doxapram
  • 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-
  • 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one
  • 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-
  • AHR 619
  • 1-ethyl-4-(2-(morpholin-4-yl)ethyl)-3,3-diphenylpyrrolidin-2-one
  • Hydrochloride, Doxapram
  • Dopram
  • 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one
  • 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one
  • Doxapram (INN)
  • 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone
  • 1-ethyl-4- (2-morpholin-4-ylethyl)- 3,3-diphenyl-pyrrolidin-2-one
  • Docatone (TN)
  • Doxapram?
  • 1-Ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone
  • 309-29-5 (free)
  • (+/-)-doxapram
  • 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-pyrrolidin-2-one
  • 1-Ethyl-4-(2-morpholin-4-yl-ethyl)-3,3-diphenyl-pyrrolidin-2-one
  • (+/-)-1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
Show all 26 synonyms
  • 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone #

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
123 to 124exp.
Solubility
WHITE TO OFF-WHITE CRYSTALLINE POWDER, PRACTICALLY INSOL IN ETHER /HYDROCHLORIDE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
378.52 g/molcalc.
Exact mass
378.2307 Dacalc.
LogP (octanol/water)
3.17calc.
Topological polar surface area
32.78 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1NCC(CCN2CCOCC2)C1(c1ccccc1)c1ccccc1

O=C1NCC(CCN2CCOCC2)C1(c1ccccc1)c1ccccc1

4 rings, 26 atoms, the 4-(2-(4-Morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone ring system.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H319Causes serious eye irritation.
Precautionary statements (4)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P337 + P317If eye irritation persists: Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Doxapram suppliers

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All 66 suppliers
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Where suppliers are based

66 suppliers in 13 countries

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Doxapram price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Central Nervous System Stimulants
  • Respiratory System Agents

Roles

  • antidepressant
  • central nervous system drug
  • central nervous system stimulant
  • pharmaceutical
  • psychotropic drug

Pharmacology

Doxapram is a Respiratory Stimulant. The physiologic effect of doxapram is by means of Increased Medullary Respiratory Drive.

How it is made

Lunsford, cale, belg patent 613,734 (1962 to ah robins), ca 58, 508d (1963), corresp to brit patent 969,063, lunsford et al, j med chem 7, 302 (1964).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Doxapram is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Doxapram is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Doxapram, based on the data on this page

What is Doxapram?

Doxapram is a member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group.

What is the CAS number of Doxapram?

The CAS registry number of Doxapram is 309-29-5.

What is the molecular formula and weight of Doxapram?

The molecular formula of Doxapram is C24H30N2O2 and its molar mass is 378.52 g/mol.

What is Doxapram used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Doxapram hazardous?

Doxapram carries the GHS signal word "Warning". Main hazards: causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Doxapram?

Doxapram is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Doxapram?

CompoundList lists 66 suppliers of Doxapram in United States, China, United Kingdom, Hong Kong and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Doxapram?

Suppliers quote Doxapram on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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