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Screening compounds

Efaproxiral

Also known as Efaproxyn, 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid, 2-Dacmpp

CAS 131179-95-8Formula C20H23NO4Molar mass 341.41 g/mol
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Efaproxiral chemical structure, C20H23NO4, CAS 131179-95-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
131179-95-8
Formula
C20H23NO4
Molar mass
341.41 g/mol
HS code
292429
Category
Screening compounds

What is Efaproxiral?

Plain description, key identifiers and synonyms

Efaproxiral is a synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. (NCI04)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid
CAS number
131179-95-8 CAS number cross-checked
Molecular formula
C20H23NO4
UNII
J81E81G364
MDL number
MFCD00899086
InChIKey
BNFRJXLZYUTIII-UHFFFAOYSA-N
InChI
InChI=1S/C20H23NO4/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3,4)19(23)24/h5-11H,12H2,1-4H3,(H,21,22)(H,23,24)
SMILES (canonical and isomeric)
CC1=CC(=CC(=C1)NC(=O)CC2=CC=C(C=C2)OC(C)(C)C(=O)O)C

Synonyms

  • Efaproxyn
  • 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid
  • 2-Dacmpp
  • 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid
  • 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoic acid
  • efaproxiralum
  • 2-(4-{[(3,5-dimethylphenyl)carbamoyl]methyl}phenoxy)-2-methylpropanoic acid
  • 2-(4-(((3,5-dimethylphenyl)carbamoyl)methyl)phenoxy)-2-methylpropanoic acid
  • 2-(4-{2-[(3,5-dimethylphenyl)amino]-2-oxoethyl}phenoxy)-2-methylpropanoic acid
  • RSR13 cpd
  • Rsr 13
  • 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid
  • Propanoic acid, 2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methyl-
  • Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
  • 2-(4-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanic acid
  • 2-{4-[(3,5-Dimethylanilino)-carbonyl-methyl]-phenoxy}-2-methylpropionic acid
  • 2-{4-[2-(3,5-Dimethylanilino)-2-oxoethyl]phenoxy}-2-methylpropanoic acid
  • 2-[4-[(3,5-Dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanic acid
  • Efaproxiral (USAN/INN)
  • 2-[4-[2-(3,5-dimethylanilino)-2-oxo-ethyl]phenoxy]-2-methyl-propanoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
341.41 g/molcalc.
Exact mass
341.1627 Dacalc.
LogP (octanol/water)
3.73calc.
Topological polar surface area
75.63 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
25calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Cc1ccccc1)Nc1ccccc1

O=C(Cc1ccccc1)Nc1ccccc1

2 rings, 16 atoms, the N,2-Diphenylacetamide ring system.

1,530 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Efaproxiral suppliers

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Where suppliers are based

1 supplier in 1 country

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Efaproxiral price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antisickling Agents
  • Radiation-Sensitizing Agents

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Efaproxiral is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Efaproxiral is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Efaproxiral, based on the data on this page

What is Efaproxiral?

Efaproxiral is a synthetic small molecule with radiosensitizing activity. Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. (NCI04)

What is the CAS number of Efaproxiral?

The CAS registry number of Efaproxiral is 131179-95-8.

What is the molecular formula and weight of Efaproxiral?

The molecular formula of Efaproxiral is C20H23NO4 and its molar mass is 341.41 g/mol.

What is Efaproxiral used for?

Known uses and roles of Efaproxiral include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, pharmaceutical, antisickling agents and 1 more.

Is Efaproxiral hazardous?

No GHS hazard classification for Efaproxiral is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Efaproxiral?

Efaproxiral is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Efaproxiral?

CompoundList lists 1 supplier of Efaproxiral in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Efaproxiral?

Suppliers quote Efaproxiral on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Efaproxiral

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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