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Screening compounds

Enadoline

Also known as Enadolina, 2-(1-benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide, 4-Benzofuranacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5R-(5alpha,7alpha,8beta))-

CAS 124378-77-4Formula C24H32N2O3Molar mass 396.53 g/mol
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Enadoline chemical structure, C24H32N2O3, CAS 124378-77-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
124378-77-4
Formula
C24H32N2O3
Molar mass
396.53 g/mol
HS code
293499
Category
Screening compounds

What is Enadoline?

Plain description, key identifiers and synonyms

Enadoline is a chemical substance with the molecular formula C24H32N2O3 and a molar mass of 396.53 g/mol. Its CAS registry number is 124378-77-4. The IUPAC name is 2-(1-benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(1-benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide
CAS number
124378-77-4 CAS number cross-checked
Molecular formula
C24H32N2O3
UNII
KJL283326C
InChIKey
JMBYBVLCYODBJQ-HFMPRLQTSA-N
InChI
InChI=1S/C24H32N2O3/c1-25(23(27)16-18-6-4-7-22-19(18)9-15-28-22)20-8-11-24(10-5-14-29-24)17-21(20)26-12-2-3-13-26/h4,6-7,9,15,20-21H,2-3,5,8,10-14,16-17H2,1H3/t20-,21-,24-/m0/s1
Canonical SMILES
CN(C(=O)Cc1cccc2occc12)C1CCC2(CCCO2)CC1N1CCCC1
Isomeric SMILES
CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)CC4=C5C=COC5=CC=C4

Synonyms

  • Enadolina
  • 2-(1-benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide
  • 4-Benzofuranacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5R-(5alpha,7alpha,8beta))-
  • enadolinum
  • N-Methyl-N-(7-(1-pyrolidinyl)-1-oxaspiro(4,5)dec-8-yl)-4-benzofuranacetamide
  • 2-(1-benzofuran-4-yl)-N-methyl-N-((5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro(4.5)decan-8-yl)acetamide
  • CI 977
  • 2-(Benzofuran-4-yl)-N-methyl-N-((5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl)acetamide
  • [3H]enadoline
  • [3H]-enadoline
  • [3H]CI977
  • [3H]-CI977
  • [3H]CI-977
  • 4-Benzofuranacetamide, N-methyl-N-((5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-
  • 2-(1-benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide
  • 1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl-amino]-1-oxa-spiro[4.5]dec-7-yl}-pyrrolidinium
  • 2-Benzofuran-4-yl-N-methyl-N-((5R,7S,8S)-7-pyrrolidin-1-yl-1-oxa-spiro[4.5]dec-8-yl)-acetamide
  • 4-Benzofuranacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5r-(5alpha,7alpha,8.beta.))-
  • N-Methyl-N-((5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-4-benzofuranacetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
396.53 g/molcalc.
Exact mass
396.2413 Dacalc.
LogP (octanol/water)
4calc.
Topological polar surface area
45.92 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
29calc.
Rings
5calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.63calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Cc1cccc2occc12)NC1CCC2(CCCO2)CC1N1CCCC1

O=C(Cc1cccc2occc12)NC1CCC2(CCCO2)CC1N1CCCC1

5 rings, 28 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Enadoline suppliers

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Enadoline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Analgesic.

Orphan Drug (Enadoline hydrochloride).

A centrally acting selective kappa-opioid agonist (Enadoline hydrochloride).

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Neuroprotective Agents

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Enadoline is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Enadoline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Enadoline, based on the data on this page

What is Enadoline?

Enadoline is a chemical substance with the molecular formula C24H32N2O3 and a molar mass of 396.53 g/mol. Its CAS registry number is 124378-77-4. The IUPAC name is 2-(1-benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide.

What is the CAS number of Enadoline?

The CAS registry number of Enadoline is 124378-77-4.

What is the molecular formula and weight of Enadoline?

The molecular formula of Enadoline is C24H32N2O3 and its molar mass is 396.53 g/mol.

What is Enadoline used for?

Analgesic. Orphan Drug (Enadoline hydrochloride). A centrally acting selective kappa-opioid agonist (Enadoline hydrochloride).

Is Enadoline hazardous?

No GHS hazard classification for Enadoline is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Enadoline?

Enadoline is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Enadoline?

Post a free request on CompoundList and suppliers of Enadoline will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Enadoline?

Suppliers quote Enadoline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Enadoline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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