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Screening compounds

(-)-Epipodophyllotoxin

Also known as Epipodophyllotoxin, (5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one, (5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-(2)benzofuro(5,6-f)(1,3)benzodioxol-8-one

CAS 4375-07-9Formula C22H22O8Molar mass 414.41 g/mol
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(-)-Epipodophyllotoxin chemical structure, C22H22O8, CAS 4375-07-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
4375-07-9
Formula
C22H22O8
Molar mass
414.41 g/mol
HS code
293220
Category
Screening compounds

What is (-)-Epipodophyllotoxin?

Plain description, key identifiers and synonyms

epipodophyllotoxin has been reported in Juniperus sabina and Podophyllum peltatum.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
CAS number
4375-07-9
Molecular formula
C22H22O8
InChIKey
YJGVMLPVUAXIQN-LGWHJFRWSA-N
InChI
InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20+/m0/s1
Canonical SMILES
COc1cc(C2c3cc4c(cc3C(O)C3COC(=O)C23)OCO4)cc(OC)c1OC
Isomeric SMILES
COC1=CC(=CC(=C1OC)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O

Synonyms

  • Epipodophyllotoxin
  • (5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
  • (5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-(2)benzofuro(5,6-f)(1,3)benzodioxol-8-one
  • (5R,5aR,8aR,9S)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
  • Eipodophyllotoxin
  • Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)-
  • (5R)-5beta-(3,4,5-Trimethoxyphenyl)-7alpha-(hydroxymethyl)-8alpha-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6beta-carboxylic acid 6,7-lactone
  • Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)-
  • Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-beta,8a-alpha,9-beta))-
  • (10R,11R,15R,16S)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one
  • (10R,11R,15R,16S)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1(9),2,7-trien-12-one
  • (5R)-5,5aalpha,8abeta,9-Tetrahydro-9alpha-hydroxy-5beta-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(8H)-one
  • (5R)-5,8,8abeta,9-Tetrahydro-9alpha-hydroxy-5beta-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-(5aalphaH)-one
  • (5R)-5|A-(3,4,5-Trimethoxyphenyl)-7|A-(hydroxymethyl)-8|A-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6|A-carboxylic acid 6,7-lactone
  • (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)-9-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
  • (5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
414.41 g/molcalc.
Exact mass
414.1315 Dacalc.
LogP (octanol/water)
2.41calc.
Topological polar surface area
92.68 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
4calc.
Heavy atoms
30calc.
Rings
5calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.41calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1OCC2Cc3cc4c(cc3C(c3ccccc3)C12)OCO4

O=C1OCC2Cc3cc4c(cc3C(c3ccccc3)C12)OCO4

5 rings, 23 atoms.

68 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(-)-Epipodophyllotoxin suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 2 countries

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(-)-Epipodophyllotoxin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Epipodophyllotoxin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Epipodophyllotoxin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Epipodophyllotoxin, based on the data on this page

What is (-)-Epipodophyllotoxin?

epipodophyllotoxin has been reported in Juniperus sabina and Podophyllum peltatum.

What is the CAS number of (-)-Epipodophyllotoxin?

The CAS registry number of (-)-Epipodophyllotoxin is 4375-07-9.

What is the molecular formula and weight of (-)-Epipodophyllotoxin?

The molecular formula of (-)-Epipodophyllotoxin is C22H22O8 and its molar mass is 414.41 g/mol.

What is (-)-Epipodophyllotoxin used for?

Known uses and roles of (-)-Epipodophyllotoxin include building blocks in research and laboratory and screening compounds in research and laboratory.

Is (-)-Epipodophyllotoxin hazardous?

No GHS hazard classification for (-)-Epipodophyllotoxin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (-)-Epipodophyllotoxin?

(-)-Epipodophyllotoxin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (-)-Epipodophyllotoxin?

CompoundList lists 3 suppliers of (-)-Epipodophyllotoxin in United States and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (-)-Epipodophyllotoxin?

Suppliers quote (-)-Epipodophyllotoxin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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