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Screening compounds

Epitinib

Also known as HMPL-813, 4-ethyl-N-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]piperazine-1-carboxamide, 4-Ethyl-N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]-1-piperazinecarboxamide

CAS 1203902-67-3Formula C24H26N6O2Molar mass 430.51 g/mol
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Epitinib chemical structure, C24H26N6O2, CAS 1203902-67-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1203902-67-3
Formula
C24H26N6O2
Molar mass
430.51 g/mol
HS code
293359
Category
Screening compounds

What is Epitinib?

Plain description, key identifiers and synonyms

Epitinib is an orally available epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon administration, epitinib inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling. This may lead to induction of cell death and inhibition of tumor growth in EGFR-overexpressing tumor cells. EGFR is a receptor tyrosine kinase (RTK) that is overexpressed in certain tumor types and plays a key role in tumor cell proliferation and vascularization.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-ethyl-N-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]piperazine-1-carboxamide
CAS number
1203902-67-3
Molecular formula
C24H26N6O2
UNII
WZ97ZE4UUG
InChIKey
DQAZPZIYEOGZAF-UHFFFAOYSA-N
InChI
InChI=1S/C24H26N6O2/c1-4-17-7-6-8-18(13-17)27-23-19-14-21(22(32-3)15-20(19)25-16-26-23)28-24(31)30-11-9-29(5-2)10-12-30/h1,6-8,13-16H,5,9-12H2,2-3H3,(H,28,31)(H,25,26,27)
SMILES (canonical and isomeric)
CCN1CCN(CC1)C(=O)NC2=C(C=C3C(=C2)C(=NC=N3)NC4=CC=CC(=C4)C#C)OC

Synonyms

  • HMPL-813
  • 4-ethyl-N-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]piperazine-1-carboxamide
  • 4-Ethyl-N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]-1-piperazinecarboxamide
  • compound 68
  • 4-Ethyl-N-(4-((3-ethynylphenyl)amino)-7-methoxy-6-quinazolinyl)-1-piperazinecarboxamide
  • compound 68 (WO2010002845A2)
  • 4-ethyl-N-(4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl)piperazine-1-carboxamide
  • 4-ethyl-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)piperazine-1-carboxamide
  • HMPL813
  • 4-Ethyl-n-{4-[(3-ethynylphenyl)amino]-7-methoxyquinazolin-6-ylpiperazine-1-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
430.51 g/molcalc.
Exact mass
430.2117 Dacalc.
LogP (octanol/water)
3.53calc.
Topological polar surface area
82.62 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
32calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccc2ncnc(Nc3ccccc3)c2c1)N1CCNCC1

O=C(Nc1ccc2ncnc(Nc3ccccc3)c2c1)N1CCNCC1

4 rings, 26 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Epitinib suppliers

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Epitinib price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Epitinib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Epitinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Epitinib, based on the data on this page

What is Epitinib?

Epitinib is an orally available epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon administration, epitinib inhibits the activity of EGFR, thereby preventing EGFR-mediated signaling.

What is the CAS number of Epitinib?

The CAS registry number of Epitinib is 1203902-67-3.

What is the molecular formula and weight of Epitinib?

The molecular formula of Epitinib is C24H26N6O2 and its molar mass is 430.51 g/mol.

What is Epitinib used for?

Known uses and roles of Epitinib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Epitinib hazardous?

No GHS hazard classification for Epitinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Epitinib?

Epitinib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Epitinib?

Post a free request on CompoundList and suppliers of Epitinib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Epitinib?

Suppliers quote Epitinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Epitinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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