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Hormones and steroids

Estradiol

Also known as beta-Estradiol, 17beta-Estradiol, Oestradiol

CAS 50-28-2Formula C18H24O2Molar mass 272.39 g/molEC 200-023-8
GHS signal word: Danger. Pictograms: Serious health hazard, Hazardous to the environment 123 suppliers listed Drug substance
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Estradiol chemical structure, C18H24O2, CAS 50-28-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White crystalline powder. Prisms from 80% alcohol
Melting point
178.5 °C
Solubility
In water, 3.90 mg/L at 27 °C
HS code
293723
Category
Hormones and steroids
Illustrative photo, off-white crystalline powder in an HDPE jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Estradiol?

Plain description, key identifiers and synonyms

17beta-estradiol is the 17beta-isomer of estradiol. It has a role as a geroprotector, an estrogen, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a mouse metabolite, a human metabolite and a Daphnia magna metabolite. It is an estradiol and a 17beta-hydroxy steroid.

Estradiol is a primary female sex hormone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CAS number
50-28-2 CAS number cross-checkedOther or deprecated CAS: 17916-67-5
EC number
200-023-8
Molecular formula
C18H24O2
UNII
4TI98Z838E
MDL number
MFCD00003693
INCI name
ESTRADIOL
InChIKey
VOXZDWNPVJITMN-ZBRFXRBCSA-N
InChI
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
Canonical SMILES
CC12CCC3c4ccc(O)cc4CCC3C1CCC2O
Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O

Synonyms

  • beta-Estradiol
  • 17beta-Estradiol
  • Oestradiol
  • Estrace
  • Dihydrofolliculin
  • Aquadiol
  • Diogynets
  • Divigel
  • Vivelle
  • Diogyn
  • Dihydrotheelin
  • Dihydroxyestrin
  • Dimenformon
  • Estraderm
  • Femestral
  • Gynoestryl
  • Aerodiol
  • Climara
  • Gynergon
  • Vagifem
  • Estraldine
  • Estrogel
  • Evorel
  • Estring
  • Systen
Show all 39 synonyms
  • Zumenon
  • estradiol-17beta
  • cis-Estradiol
  • Compudose
  • Innofem
  • Alora
  • Fempatch
  • Gynodiol
  • Ovocylin
  • Esclim
  • 17beta-Oestradiol
  • Elestrin
  • Evamist
  • 17-beta-estradiol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White crystalline powder. Prisms from 80% alcoholexp.
Odour
Odorlessexp.
Melting point
178.5 °Cexp.
Solubility
In water, 3.90 mg/L at 27 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
272.39 g/molcalc.
Exact mass
272.1776 Dacalc.
LogP (octanol/water)
3.61calc.
Topological polar surface area
40.46 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
20calc.
Rings
4calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
5calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCC1C2CCC2CCCC21

c1ccc2c(c1)CCC1C2CCC2CCCC21

4 rings, 17 atoms.

585 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H350May cause cancer.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H360FDMay damage fertility. May damage the unborn child.
  • H362May cause harm to breast-fed children.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (12)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Estradiol suppliers

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All 123 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

123 suppliers in 18 countries

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Estradiol price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals, Animal Drugs.

Cosmetic ingredient, INCI name ESTRADIOL(skin conditioning)

Pharmacological actions

  • Estrogens

Roles

  • Daphnia magna metabolite
  • Daphnia metabolite
  • agonist
  • animal metabolite
  • crustacean metabolite
  • enzyme inhibitor
  • estrogen
  • eukaryotic metabolite
  • geroprotector
  • hormone
  • human metabolite
  • mammalian metabolite
  • metabolite
  • molecular messenger
  • mouse metabolite
  • pharmaceutical
  • protective agent
  • sex hormone

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Estradiol is an Estrogen. The mechanism of action of estradiol is as an Estrogen Receptor Agonist.

How it is made

Estradiol-17beta is produced commercially by the reduction of estrone using, for example, complex metal hydrides, such as sodium borohydride and lithium aluminum hydride.

Has been isolated from ovarian follicular fluid and from placental tissue ... It is usually prepared through reduction of the 17-keto group of Estrone.

Isolated from human and mare pregnancy urine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Estradiol is traded under.

HS 2937.23Indicative HS code

Oestrogens and progestogens

World exports in 2024
$762M
−2.3% vs 2023, imports $693M
2019 to 2024
Top exporters
  1. China42.9%
  2. Italy18.4%
  3. Netherlands8.9%
Top importers
  1. India * partner reported12.1%
  2. United States11.0%
  3. Belgium8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Estradiol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Estradiol, based on the data on this page

What is Estradiol?

17beta-estradiol is the 17beta-isomer of estradiol. It has a role as a geroprotector, an estrogen, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a mouse metabolite, a human metabolite and a Daphnia magna metabolite. It is an estradiol and a 17beta-hydroxy steroid.

What is the CAS number of Estradiol?

The CAS registry number of Estradiol is 50-28-2. Other or deprecated CAS numbers: 17916-67-5.

What is the molecular formula and weight of Estradiol?

The molecular formula of Estradiol is C18H24O2 and its molar mass is 272.39 g/mol.

What is Estradiol used for?

Use classes: Pharmaceuticals, Animal Drugs.

Is Estradiol hazardous?

Estradiol carries the GHS signal word "Danger". Main hazards: may cause cancer, suspected of causing cancer, may damage fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Estradiol?

Estradiol is usually classified under HS code 293723 (Oestrogens and progestogens). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Estradiol?

CompoundList lists 123 suppliers of Estradiol in China, United States, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Estradiol in India?

11 suppliers in India list Estradiol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Estradiol?

Suppliers quote Estradiol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Estradiol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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