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Central nervous system drugs

Etazolate

Also known as Etazolato, Etazolatum, 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester

CAS 51022-77-6Formula C14H19N5O2Molar mass 289.34 g/mol
1 supplier listed
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Etazolate chemical structure, C14H19N5O2, CAS 51022-77-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
51022-77-6
Formula
C14H19N5O2
Molar mass
289.34 g/mol
HS code
293399
Category
Central nervous system drugs

What is Etazolate?

Plain description, key identifiers and synonyms

Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as an antidepressant, an anxiolytic drug, an antipsychotic agent, a GABA agent, a neuroprotective agent, a phosphodiesterase IV inhibitor and an alpha-secretase activator. It is an ethyl ester, a hydrazone and a pyrazolopyridine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate
CAS number
51022-77-6 CAS number cross-checked
Molecular formula
C14H19N5O2
UNII
I89Y79062L
InChIKey
OPQRBXUBWHDHPQ-UHFFFAOYSA-N
InChI
InChI=1S/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18)
SMILES (canonical and isomeric)
CCN1C2=NC=C(C(=C2C=N1)NN=C(C)C)C(=O)OCC

Synonyms

  • Etazolato
  • Etazolatum
  • 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester
  • ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[4,5-e]pyridine-5-carboxylate
  • ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo(4,5-e)pyridine-5-carboxylate
  • ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate
  • ethyl 1-ethyl-4-(2-isopropylidenehydrazino)pyrazolo[3,4-b]pyridine-5-carboxylate
  • Ethyl 1-ethyl-4-(2-(propan-2-ylidene)hydrazineyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
  • Ethyl 1-ethyl-4-[2-(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
  • SQ 20,009
  • Tocris-0438
  • ethyl 1-ethyl-4-(2-isopropylidenehydrazino)-1h-pyrazolo[3,4-b]pyridine-5-carboxylate
  • Etazolate hydrochloride(USAN)
  • HSCI1_000299
  • Sdccgsbi-0050425.p002
  • 1H-Pyrazolo[3,4-b]pyridine-5-carboxylicacid, 1-ethyl-4-[2-(1-methylethylidene)hydrazinyl]-, ethyl ester, hydrochloride(1:1)
  • ethyl 1-ethyl-4-[2-(propan-2-ylidene)hydrazin-1-yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
  • SQ-20,009
  • Ethyl 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo(3,4-b)pyridine-5-carboxylate
  • 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester
  • 1-Ethyl-4-(N'-isopropylidene-hydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester
  • 1-Ethyl-4-[2-(1-methylethylidene)hydrazinyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
289.34 g/molcalc.
Exact mass
289.1539 Dacalc.
LogP (octanol/water)
2.44calc.
Topological polar surface area
81.4 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
5calc.
Heavy atoms
21calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cnc2[nH]ncc2c1

c1cnc2[nH]ncc2c1

2 rings, 9 atoms, the 1H-Pyrazolo(3,4-b)pyridine ring system.

1,219 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Etazolate suppliers

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  • Synblock Inc
    Canada, MontrealUnclaimed profile
    EtazolateGrade, purity and minimum order on request
    Price on request
    View

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Where suppliers are based

1 supplier in 1 country

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Etazolate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antipsychotic Agents
  • Phosphodiesterase Inhibitors

Roles

  • GABA agent
  • activator
  • alpha-secretase activator
  • antidepressant
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • enzyme activator
  • enzyme inhibitor
  • neuroprotective agent
  • neurotransmitter agent
  • pharmaceutical
  • phosphodiesterase IV inhibitor
  • protective agent
  • psychotropic drug
  • tranquilizing drug

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Etazolate is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Etazolate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Etazolate, based on the data on this page

What is Etazolate?

Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties.

What is the CAS number of Etazolate?

The CAS registry number of Etazolate is 51022-77-6.

What is the molecular formula and weight of Etazolate?

The molecular formula of Etazolate is C14H19N5O2 and its molar mass is 289.34 g/mol.

What is Etazolate used for?

Known uses and roles of Etazolate include cns agents in pharmaceuticals, gaba agent, activator, alpha-secretase activator, antidepressant and 15 more.

Is Etazolate hazardous?

No GHS hazard classification for Etazolate is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Etazolate?

Etazolate is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Etazolate?

CompoundList lists 1 supplier of Etazolate in Canada. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Etazolate?

Suppliers quote Etazolate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Etazolate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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