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Insecticides and acaricides

Ethion

Also known as Diethion, Nialate, Ethanox

CAS 563-12-2Formula C9H22O4P2S4Molar mass 384.49 g/molEC 209-242-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Hazardous to the environment 21 suppliers listed
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Ethion chemical structure, C9H22O4P2S4, CAS 563-12-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Water-white to amber-colored liquid
Melting point
-13 to -12
Boiling point
>150
Density
Relative density (water = 1): 1.2
Flash point
176.1 °C
HS code
293090
Category
Insecticides and acaricides
UN number
UN 3018
Illustrative photo, clear liquid in sealed glass ampoules on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Ethion?

Plain description, key identifiers and synonyms

Ethion is an organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7). It has a role as an acaricide, an insecticide, an agrochemical, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an environmental contaminant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
diethoxyphosphinothioylsulfanylmethylsulfanyl-diethoxy-sulfanylidene-λ5-phosphane
CAS number
563-12-2 CAS number cross-checked
EC number
209-242-3
Molecular formula
C9H22O4P2S4
UNII
2TI07NO12Y
MDL number
MFCD00036232
InChIKey
RIZMRRKBZQXFOY-UHFFFAOYSA-N
InChI
InChI=1S/C9H22O4P2S4/c1-5-10-14(16,11-6-2)18-9-19-15(17,12-7-3)13-8-4/h5-9H2,1-4H3
SMILES (canonical and isomeric)
CCOP(=S)(OCC)SCSP(=S)(OCC)OCC

Synonyms

  • Diethion
  • Nialate
  • Ethanox
  • Ethopaz
  • Niagara 1240
  • Embathion
  • Ethodan
  • Hylemox
  • Rhodocide
  • Rodocid
  • Phosphotox E
  • Fosfatox E
  • Fosfono 50
  • Vegfru fosmite
  • KWIT
  • Ethiol 100
  • Ethiol
  • RP 8167
  • Ethyl methylene phosphorodithioate
  • Bis(S-(diethoxyphosphinothioyl)mercapto)methane
  • NIA 1240
  • S,S'-Methylene bis(O,O-diethyl phosphorodithioate)
  • Hylemax
  • Rodocide
  • Itopaz
Show all 39 synonyms
  • ENT 24,105
  • o,o,o',o'-tetraethyl s,s'-methylene bis(phosphorodithioate)
  • O,O,O',O'-Tetraethyl S,S'-methylenebis(phosphorodithioate)
  • Phosphorodithioic acid, S,S'-methylene O,O,O',O'-tetraethyl ester
  • O,O,O',O'-Tetraaethyl-bis(dithiophosphat)
  • Tetraethyl S,S'-methylene bis(phosphorothiolothionate)
  • O,O,O',O'-Tetraethyl S,S'-methylenebisphosphordithioate
  • S,S'-Methylene O,O,O',O'-tetraethyl phosphorodithioate
  • O,O,O',O'-Tetraethyl-S,S'-methylenebisphosphorodithioate
  • Methyleen-S,S'-bis(O,O-diethyl-dithiofosfaat)
  • O,O,O',O'-Tetraethyl S,S'-Methylene bisphosphorodithioate
  • S,S'-Methylen-bis(O,O-diaethyl-dithiophosphat)
  • Methylene-S,S'-bis(O,O-diaethyl-dithiophosphat)
  • Phosphorodithioic acid, O,O-diethyl ester, S,S-diester with methanedithiol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Water-white to amber-colored liquidexp.
Odour
Odorless [Note: The technical product has a very disagreeable odor].exp.
Melting point
-13 to -12exp.
Boiling point
>150exp.
Density
Relative density (water = 1): 1.2exp.
Flash point
176.1 °Cexp.
Autoignition temperature
Not flammableexp.
Solubility
In water, 2.0 mg/l @ 25 °Cexp.
Vapour pressure
1.5 × 10⁻⁶ mm Hg @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
384.49 g/molcalc.
Exact mass
383.9876 Dacalc.
LogP (octanol/water)
5.01calc.
Topological polar surface area
36.92 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
12calc.
Heavy atoms
19calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H312Harmful in contact with skin.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (13)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3018
Transport hazard class
6.1
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ethion suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 21 suppliers
21 of 21 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

21 suppliers in 3 countries

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Ethion price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Insecticide and acaricide for citrus fruit, apples, nuts, other fruit, & cotton. (Former use).

/It is used/ for control of aphids, mites (including eriophyd mites), scales, thrips, leafhoppers, maggots, and foliar feeding larvae and on a wide variety of food, fiber, and ornamental crops. (Former use).

Ethion is a non-systemic insecticide and acaricide.

Use classes: Organophosphates and carbamates, Insecticides.

Pharmacological actions

  • Insecticides

Roles

  • acaricide
  • agrochemical
  • environmental contaminant
  • enzyme inhibitor
  • insecticide
  • pesticide

Functional uses

  • Biocide

Pharmacology

Ethion is a synthetic organophosphate pesticide that is an acetylcholinesterase inhibitor. It is characterized as a clear to yellow or amber liquid with a sulfur-like smell, and exposure occurs by inhalation, ingestion, or contact.

How it is made

Reaction of methylene bromide & the sodium salt of o,o-diethylphosphorodithioate

/It is made/ by interaction of dibromomethane with o,o-diethyl hydrogen phosphorodithioate in ethanol at controlled ph. Canadian patent 845,731 & 851,217.

Willard, Henahan, US patents 2,873,228 and 3,014,058 (1959, 1961 to FMC)

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-047-00-2

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ethion is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Ethion is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ethion, based on the data on this page

What is Ethion?

Ethion is an organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7).

What is the CAS number of Ethion?

The CAS registry number of Ethion is 563-12-2.

What is the molecular formula and weight of Ethion?

The molecular formula of Ethion is C9H22O4P2S4 and its molar mass is 384.49 g/mol.

What is Ethion used for?

Insecticide and acaricide for citrus fruit, apples, nuts, other fruit, & cotton. (Former use). /It is used/ for control of aphids, mites (including eriophyd mites), scales, thrips, leafhoppers, maggots, and foliar feeding larvae and on a wide variety of food, fiber, and ornamental crops. (Former use).

Is Ethion hazardous?

Ethion carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful in contact with skin, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ethion?

Ethion is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ethion?

CompoundList lists 21 suppliers of Ethion in India, Germany and Iran. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ethion in India?

18 suppliers in India list Ethion on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ethion?

Suppliers quote Ethion on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ethion

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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