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Screening compounds

Exicorilant

Also known as WHO 10854, Exicorilant (USAN/INN)

CAS 1781244-77-6Formula C26H23F4N7O3SMolar mass 589.58 g/mol
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Exicorilant chemical structure, C26H23F4N7O3S, CAS 1781244-77-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1781244-77-6
Formula
C26H23F4N7O3S
Molar mass
589.58 g/mol
HS code
293590
Category
Screening compounds

What is Exicorilant?

Plain description, key identifiers and synonyms

Exicorilant is an orally available, selective glucocorticoid receptor (GR) antagonist, with potential antineoplastic activity. Upon oral administration, exicorilant competitively and selectively binds to GRs, inhibiting the activation of GR-mediated proliferative and anti-apoptotic gene expression pathways. The GR, a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is overexpressed in certain tumor types and may be associated with tumor cell proliferation and treatment resistance. Inhibition of GR activity may potentially slow tumor cell growth and disease progression in certain cancers.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(4aR,8aS)-1-(4-fluorophenyl)-6-(2-methyltriazol-4-yl)sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[5,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)-2-pyridinyl]methanone
CAS number
1781244-77-6
Molecular formula
C26H23F4N7O3S
UNII
GTB859B7K8
InChIKey
HWJYJKAURRIWJM-GKVSMKOHSA-N
InChI
InChI=1S/C26H23F4N7O3S/c1-35-32-14-23(34-35)41(39,40)36-9-7-17-11-22-16(13-33-37(22)20-4-2-19(27)3-5-20)12-25(17,15-36)24(38)21-10-18(6-8-31-21)26(28,29)30/h2-6,8,10,13-14,17H,7,9,11-12,15H2,1H3/t17-,25-/m0/s1
Canonical SMILES
Cn1ncc(S(=O)(=O)N2CCC3Cc4c(cnn4-c4ccc(F)cc4)CC3(C(=O)c3cc(C(F)(F)F)ccn3)C2)n1
Isomeric SMILES
CN1N=CC(=N1)S(=O)(=O)N2CC[C@H]3CC4=C(C[C@@]3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F

Synonyms

  • WHO 10854
  • Exicorilant (USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
589.58 g/molcalc.
Exact mass
589.1519 Dacalc.
LogP (octanol/water)
3.23calc.
Topological polar surface area
115.9 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
5calc.
Heavy atoms
41calc.
Rings
6calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(c1ccccn1)C12Cc3cnn(-c4ccccc4)c3CC1CCN(S(=O)(=O)c1cn[nH]n1)C2

O=C(c1ccccn1)C12Cc3cnn(-c4ccccc4)c3CC1CCN(S(=O)(=O)c1cn[nH]n1)C2

6 rings, 35 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Exicorilant suppliers

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Exicorilant price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Exicorilant is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Exicorilant is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Exicorilant, based on the data on this page

What is Exicorilant?

Exicorilant is an orally available, selective glucocorticoid receptor (GR) antagonist, with potential antineoplastic activity. Upon oral administration, exicorilant competitively and selectively binds to GRs, inhibiting the activation of GR-mediated proliferative and anti-apoptotic gene expression pathways.

What is the CAS number of Exicorilant?

The CAS registry number of Exicorilant is 1781244-77-6.

What is the molecular formula and weight of Exicorilant?

The molecular formula of Exicorilant is C26H23F4N7O3S and its molar mass is 589.58 g/mol.

What is Exicorilant used for?

Known uses and roles of Exicorilant include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Exicorilant hazardous?

No GHS hazard classification for Exicorilant is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Exicorilant?

Exicorilant is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Exicorilant?

Post a free request on CompoundList and suppliers of Exicorilant will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Exicorilant?

Suppliers quote Exicorilant on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Exicorilant

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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