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Screening compounds

Fadraciclib

Also known as (2R,3S)-3-[[6-[(4,6-dimethylpyridin-3-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol, 2-Pentanol, 3-((6-(((4,6-dimethyl-3-pyridinyl)methyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-, (2R,3S)-, (2R,3S)-3-((6-((4,6-dimethylpyridin-3-yl)methylamino)-9-propan-2-ylpurin-2-yl)amino)pentan-2-ol

CAS 1070790-89-4Formula C21H31N7OMolar mass 397.53 g/mol
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Fadraciclib chemical structure, C21H31N7O, CAS 1070790-89-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1070790-89-4
Formula
C21H31N7O
Molar mass
397.53 g/mol
HS code
293359
Category
Screening compounds

What is Fadraciclib?

Plain description, key identifiers and synonyms

Fadraciclib is an orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9), with potential antineoplastic and chemoprotective activities. Upon oral administration, fadraciclib selectively binds to and inhibits the activity of CDK2, 5 and 9, which leads to inhibition of CDK2, 5 and 9-dependent cellular pathways, downregulation of genes involved in the pro-survival pathway, prevention of the activation of DNA double-strand break repair pathways, and induction of both cell cycle arrest and apoptosis. This inhibits the proliferation of CDK2/5/9-overexpressing tumor cells. In addition, CYC065 protects hematopoietic stem and progenitor cells (HSPCs), prevents myelosuppression, and preserves the function of the bone marrow. CDKs are serine/threonine kinases involved in the regulation of the cell cycle and may be overexpressed in certain cancer cell types, they play key roles in tumor cell proliferation, the regulation of transcription, and DNA damage repair.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2R,3S)-3-[[6-[(4,6-dimethyl-3-pyridinyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol
CAS number
1070790-89-4
Molecular formula
C21H31N7O
UNII
YET2XNU791
MDL number
MFCD21496424
InChIKey
DLPIYBKBHMZCJI-WBVHZDCISA-N
InChI
InChI=1S/C21H31N7O/c1-7-17(15(6)29)25-21-26-19(18-20(27-21)28(11-24-18)12(2)3)23-10-16-9-22-14(5)8-13(16)4/h8-9,11-12,15,17,29H,7,10H2,1-6H3,(H2,23,25,26,27)/t15-,17+/m1/s1
Canonical SMILES
CCC(Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)C(C)O
Isomeric SMILES
CC[C@@H]([C@@H](C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CN=C(C=C3C)C

Synonyms

  • (2R,3S)-3-[[6-[(4,6-dimethylpyridin-3-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol
  • 2-Pentanol, 3-((6-(((4,6-dimethyl-3-pyridinyl)methyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-, (2R,3S)-
  • (2R,3S)-3-((6-((4,6-dimethylpyridin-3-yl)methylamino)-9-propan-2-ylpurin-2-yl)amino)pentan-2-ol
  • Cyclin Dependent Kinase Inhibitor 2/5/9 CYC065
  • (2R,3S)-3-((6-(((4,6-dimethylpyridin-3-yl)methyl)amino)-9-(propan-2-yl)-9H-purin-2-yl)amino)pentan-2-ol
  • Fadraciclib | CYC065
  • Fadraciclib (CYC065)
  • (2R,3S)-3-((6-(((4,6-dimethylpyridin-3-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)pentan-2-ol
  • 1070790-89-4 (free base)
  • (2R,3S)-3-({6-[(4,6-dimethylpyridin-3-yl)(methyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)pentan-2-ol
  • US8592581, 1
  • (2R,3S)-3-[[6-[(4,6-dimethyl-3-pyridinyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol
  • (2R,3S)-3-[[6-[(4,6-dimethyl-3-pyridyl)methylamino]-9-isopropyl-purin-2-yl]amino]pentan-2-ol
  • (2R,3s)-3-[[6-[[(4,6-dimethyl-3-pyridinyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-2-pentanol
  • (2R,3S)-3-[[6-[[(4,6-Dimethyl-3-pyridyl)methyl]amino]-9-isopropyl-9H-purin-2-yl]amino]-2-pentanol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
397.53 g/molcalc.
Exact mass
397.259 Dacalc.
LogP (octanol/water)
3.6calc.
Topological polar surface area
100.8 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
8calc.
Heavy atoms
29calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.52calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cncc(CNc2ncnc3[nH]cnc23)c1

c1cncc(CNc2ncnc3[nH]cnc23)c1

3 rings, 17 atoms.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Fadraciclib suppliers

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Where suppliers are based

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Fadraciclib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fadraciclib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Fadraciclib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fadraciclib, based on the data on this page

What is Fadraciclib?

Fadraciclib is an orally bioavailable inhibitor of cyclin dependent kinases 2, 5 and 9 (CDK2/5/9), with potential antineoplastic and chemoprotective activities.

What is the CAS number of Fadraciclib?

The CAS registry number of Fadraciclib is 1070790-89-4.

What is the molecular formula and weight of Fadraciclib?

The molecular formula of Fadraciclib is C21H31N7O and its molar mass is 397.53 g/mol.

What is Fadraciclib used for?

Known uses and roles of Fadraciclib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Fadraciclib hazardous?

No GHS hazard classification for Fadraciclib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Fadraciclib?

Fadraciclib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fadraciclib?

CompoundList lists 1 supplier of Fadraciclib in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Fadraciclib?

Suppliers quote Fadraciclib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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