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Analgesics and anti-inflammatories

Fluorometholone

Also known as Oxylone, Fluor-Op, FML Forte

CAS 426-13-1Formula C22H29FO4Molar mass 376.47 g/molEC 207-041-5
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 86 suppliers listed Drug substance
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Fluorometholone chemical structure, C22H29FO4, CAS 426-13-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
426-13-1
Formula
C22H29FO4
Molar mass
376.47 g/mol
EC number
207-041-5
HS code
293722
Category
Analgesics and anti-inflammatories

What is Fluorometholone?

Plain description, key identifiers and synonyms

Fluorometholone is a member of the class of glucocorticoids that is 1-progesterone substituted at positions 11beta and 17 by hydroxy groups, at position 6alpha by a methyl group and at position 9 by a fluoro group. Used for the treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe. It has a role as an anti-inflammatory drug. It is a tertiary alpha-hydroxy ketone, a glucocorticoid, a 17alpha-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid and a 3-oxo-Delta(1),Delta(4)-steroid. It is functionally related to a Delta(1)-progesterone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS number
426-13-1 CAS number cross-checked
EC number
207-041-5
Molecular formula
C22H29FO4
UNII
SV0CSG527L
MDL number
MFCD00056461
InChIKey
FAOZLTXFLGPHNG-KNAQIMQKSA-N
InChI
InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
Canonical SMILES
CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
Isomeric SMILES
C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@]2([C@@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)O

Synonyms

  • Oxylone
  • Fluor-Op
  • FML Forte
  • Fluorometolona
  • Fluorometholonum
  • Fluorometolone
  • 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
  • Fluaton
  • (6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6alpha,11beta)-
  • Fluoro Ophtal
  • Isopto Flucon
  • Flucon, Isopto
  • Fluor Op
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl-
  • PMS Fluorometholone
  • Fml fte
  • Fml-neo
  • (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadeca-3,6-dien-5-one
  • (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
  • (6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta(a)phenanthren-3-one
  • fluorometholone ophthalmic suspension
  • Flumetholon
  • Fluoromethalone
  • Fluormetholone
Show all 37 synonyms
  • Cortilet
  • Delmeson
  • FML Liquifilm
  • Trilcin
  • FML
  • Fluormetholon
  • component of Neo-Oxylone
  • Fluorometholone (Standard)
  • Fluormetholonum
  • Neo-Oxylone
  • FML-S Liquifilm
  • (6alpha,11beta)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
376.47 g/molcalc.
Exact mass
376.205 Dacalc.
LogP (octanol/water)
2.92calc.
Topological polar surface area
74.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
27calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.73calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H332Harmful if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fluorometholone suppliers

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All 86 suppliers
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Where suppliers are based

86 suppliers in 18 countries

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Fluorometholone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Allergic Agents
  • Anti-Inflammatory Agents
  • Glucocorticoids

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • ophthalmology drug
  • pharmaceutical

Pharmacology

Fluorometholone is a Corticosteroid. The mechanism of action of fluorometholone is as a Corticosteroid Hormone Receptor Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fluorometholone is traded under.

HS 2937.22Indicative HS code

Halogenated derivatives of corticosteroidal hormones

World exports in 2024
$1.65B
−29.3% vs 2023, imports $1.67B
2019 to 2024
Top exporters
  1. United Kingdom69.1%
  2. Italy7.8%
  3. Singapore5.6%
Top importers
  1. United States64.5%
  2. Spain5.1%
  3. United Kingdom3.7%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Fluorometholone is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fluorometholone, based on the data on this page

What is Fluorometholone?

Fluorometholone is a member of the class of glucocorticoids that is 1-progesterone substituted at positions 11beta and 17 by hydroxy groups, at position 6alpha by a methyl group and at position 9 by a fluoro group.

What is the CAS number of Fluorometholone?

The CAS registry number of Fluorometholone is 426-13-1.

What is the molecular formula and weight of Fluorometholone?

The molecular formula of Fluorometholone is C22H29FO4 and its molar mass is 376.47 g/mol.

What is Fluorometholone used for?

Use classes: Pharmaceuticals.

Is Fluorometholone hazardous?

Fluorometholone carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fluorometholone?

Fluorometholone is usually classified under HS code 293722 (Halogenated derivatives of corticosteroidal hormones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fluorometholone?

CompoundList lists 86 suppliers of Fluorometholone in China, United States, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Fluorometholone in India?

7 suppliers in India list Fluorometholone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Fluorometholone?

Suppliers quote Fluorometholone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fluorometholone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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