CompoundList
Sign in
Vitamins and nutraceutical actives

Folic acid

Also known as Pteroylglutamic acid, Vitamin M, Folacid

CAS 59-30-3Formula C19H19N7O6Molar mass 441.40 g/molEC 200-419-0
347 suppliers listed Drug substance
Get quotes Compare 347 suppliers
Folic acid chemical structure, C19H19N7O6, CAS 59-30-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellowish-orange crystals, extremely thin platelets (elongated @ 2 ends) from hot water
Melting point
250 °C
Solubility
In water, 1.6 mg/L at 25 °C, soluble up to about 1% in boiling water
HS code
293629
Category
Vitamins and nutraceutical actives
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Folic acid?

Plain description, key identifiers and synonyms

Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. It has a role as a nutrient, a mouse metabolite and a human metabolite. It is a member of folic acids and a N-acyl-amino acid. It is functionally related to a pteroic acid. It is a conjugate acid of a folate(2-).

Folic acid is a compound, a vitamer of "vitamin B9".

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
CAS number
59-30-3 CAS number cross-checkedOther or deprecated CAS: 112339-08-9, 112339-32-9, 32108-06-8, 6484-89-5
EC numbers
200-419-0, 229-348-3
Molecular formula
C19H19N7O6
UNII
935E97BOY8
MDL number
MFCD00079305
INCI name
FOLIC ACID
InChIKey
OVBPIULPVIDEAO-LBPRGKRZSA-N
InChI
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
Canonical SMILES
Nc1nc2ncc(CNc3ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc3)nc2c(=O)[nH]1
Isomeric SMILES
C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N

Synonyms

  • Pteroylglutamic acid
  • Vitamin M
  • Folacid
  • Folacin
  • Vitamin Bc
  • PteGlu
  • Vitamin B9
  • Foliamin
  • Folicet
  • Folvite
  • Incafolic
  • Acifolic
  • Cytofol
  • Folcidin
  • Folettes
  • Folipac
  • Folsan
  • Millafol
  • Folsaure
  • Pteroyl-L-glutamic acid
  • Folbal
  • Folsav
  • Vitamin Be
  • Foldine
  • Pteroylmonoglutamic acid
Show all 39 synonyms
  • Pteroyl-L-monoglutamic acid
  • Facid
  • Antianemia factor
  • Factor U
  • Folico (Italy)
  • Folina (Italy)
  • Acfol (Spain)
  • Folasic (Australia)
  • Usaf cb-13
  • Foldine [France]
  • Acidum folicum
  • Acido folico
  • Dosfolat B activ
  • Folaemin [Netherlands]

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellowish-orange crystals, extremely thin platelets (elongated @ 2 ends) from hot waterexp.
Odour
Odorless or almost odorlessexp.
Taste
Tastelessexp.
Melting point
250 °Cexp.
Solubility
In water, 1.6 mg/L at 25 °C, soluble up to about 1% in boiling waterexp.
Vapour pressure
6.2 × 10⁻²⁰ mm Hg at 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
441.40 g/molcalc.
Exact mass
441.1397 Dacalc.
LogP (octanol/water)
-0.04calc.
Topological polar surface area
213.3 Ųcalc.
Hydrogen bond donors
6calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
9calc.
Heavy atoms
32calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.21calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]cnc2ncc(CNc3ccccc3)nc12

O=c1[nH]cnc2ncc(CNc3ccccc3)nc12

3 rings, 19 atoms.

106 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Folic acid suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 347 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

347 suppliers in 43 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Folic acid price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Food additive.

Vitamin. Nutritional factor.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name FOLIC ACID(skin conditioning)

Pharmacological actions

  • Hematinics
  • Vitamin B Complex

Roles

  • anti-HIV agent
  • anti-anaemic agent
  • anti-ulcer drug
  • antiatherosclerotic agent
  • anticonvulsant
  • antidepressant
  • antidote
  • antihypertensive agent
  • antimalarial
  • antineoplastic agent
  • antiparkinson drug
  • antipsychotic agent
  • antirheumatic drug
  • antitubercular agent
  • antiviral agent
  • bone density conservation agent
  • cardiovascular drug
  • human metabolite
  • hypoglycemic agent
  • mouse metabolite
  • nutrient
  • ophthalmology drug
  • pharmaceutical
  • renoprotective agent

Functional uses

  • Flavouring and nutrient
  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Pharmacology

Folic Acid is a collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions of amino acid metabolism, in addition to purine and pyrimidine synthesis, and is essential for hematopoiesis and red blood cell production. (NCI05)

How it is made

Condensation of 2,5,6-triamino-4(3H)-pyrimidinone, p-aminobenzoyl-L-glutamic acid, and 2,3-dibromopropanal.

Synthetic pteroylglutamic acid is made by the reaction of 2,3-di-bromopropanol,2,4,5-triamino-6-hydroxypyrimidine and para-aminobenzoyl glutamic acid

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Folic acid is traded under.

HS 2936.29Indicative HS code

Vitamins and their derivatives, unmixed, other vitamins and their derivatives

World exports in 2024
$2.21B
+8.7% vs 2023, imports $1.85B
2019 to 2024
Top exporters
  1. China25.3%
  2. United States14.5%
  3. Australia13.8%
Top importers
  1. United States16.4%
  2. Netherlands9.4%
  3. Spain5.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Folic acid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Folic acid, based on the data on this page

What is Folic acid?

Folic acid is an N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation. It has a role as a nutrient, a mouse metabolite and a human metabolite.

What is the CAS number of Folic acid?

The CAS registry number of Folic acid is 59-30-3. Other or deprecated CAS numbers: 112339-08-9, 112339-32-9, 32108-06-8.

What is the molecular formula and weight of Folic acid?

The molecular formula of Folic acid is C19H19N7O6 and its molar mass is 441.40 g/mol.

What is Folic acid used for?

Veterinary medication:. Food additive. Vitamin. Nutritional factor. Use classes: Cosmetics.

Is Folic acid hazardous?

No GHS hazard classification for Folic acid is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Folic acid?

Folic acid is usually classified under HS code 293629 (Vitamins and their derivatives, unmixed, other vitamins and their derivatives). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Folic acid?

CompoundList lists 347 suppliers of Folic acid in China, India, United States, Germany and 39 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Folic acid in India?

83 suppliers in India list Folic acid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Folic acid?

Suppliers quote Folic acid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Folic acid

Get quotes for Folic acid

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Folic acid
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Folic acid with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/folic-acid-59-30-3" title="Folic acid structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Vitamins and nutraceutical actives or HS code 293629

347 suppliers
Free quotes, contact stays private
Get quotes