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Impurities and reference standards

Methopterin

Also known as Methopterine, N10-Methylfolic acid, 10-Methylfolic acid

CAS 2410-93-7Formula C20H21N7O6Molar mass 455.43 g/molEC 691-132-3
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 3 suppliers listed
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Methopterin chemical structure, C20H21N7O6, CAS 2410-93-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2410-93-7
Formula
C20H21N7O6
Molar mass
455.43 g/mol
EC number
691-132-3
HS code
293359
Category
Impurities and reference standards

What is Methopterin?

Plain description, key identifiers and synonyms

Methopterine is a member of folic acids.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
CAS number
2410-93-7
EC number
691-132-3
Molecular formula
C20H21N7O6
UNII
9TJY624421
MDL number
MFCD30187666
InChIKey
HLIXOCXUWGDBNP-ZDUSSCGKSA-N
InChI
InChI=1S/C20H21N7O6/c1-27(9-11-8-22-16-15(23-11)18(31)26-20(21)25-16)12-4-2-10(3-5-12)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,8,13H,6-7,9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H3,21,22,25,26,31)/t13-/m0/s1
Canonical SMILES
CN(Cc1cnc2nc(N)[nH]c(=O)c2n1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1
Isomeric SMILES
CN(CC1=CN=C2C(=N1)C(=O)NC(=N2)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

Synonyms

  • Methopterine
  • N10-Methylfolic acid
  • 10-Methylfolic acid
  • 10-Methylpteroylglutamic acid
  • N10-Methylpteroylglutamic acid
  • N-(p-(((2-Amino-4-hydroxy-6-pteridyl)methyl)methylamino)benzoyl)glutamic acid
  • Methotrexate impurity c
  • Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridyl)methyl)methylamino)benzoyl)-
  • L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)methylamino)benzoyl)-
  • Glutamic acid, N-(p-(((2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl)methylamino)benzoyl)-, L-
  • (2S)-2-((4-(((2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)methylamino)benzoyl)amino)pentanedioic acid
  • L-Glutamic acid, N-(4-(((2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl)methylamino)benzoyl)-
  • Methotrexate impurity c (ep impurity)
  • Methotrexate EP Impurity C
  • N(10)-Methylfolate
  • (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
  • (S)-2-(4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid
  • 2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
  • (2S)-2-[[4-[[(2-amino-4-hydroxy pteridin-6-yl) methyl] methyl amino] benzoyl] amino] pentanedioic acid
  • Methotrexate EP Impurity C, <br>Methotrexate USP Related Compound C
  • (S)-2-(4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid
  • (S)-2-[4-[[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl](methyl)amino]benzamido]pentanedioic Acid
  • Methotrexate-EP-Imp-C
  • n10-methylfolic acid?
  • Methopterine (>90%)
Show all 36 synonyms
  • Methotrexate Impurity 95
  • 1-methylpteroylglutamic acid
  • Methotrexate impurity C CRS
  • (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
  • L-Glutamic acid,N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
  • L-Glutamic acid, N-[4-[[ (2-amino-1, 4-dihydro-4-oxo-6-pteridinyl)meth yl]methylamino]benzoyl]-
  • Methotrexate EP Impurity CAmethopterin EP Impurity C
  • Glutamic acid, N-{p-[(2-amino-4-hydroxy-6-pteridyl-methyl)methylamino]benzoyl}-
  • (2S)-2-[[4-[(2-amino-4-hydroxy-pteridin-6-yl)methyl-methyl-amino]benzoyl]amino]pentanedioic acid
  • (2S)-2-[[4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic Acid (N-Methylfolic Acid, Methopterin)
  • (4-(((2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
455.43 g/molcalc.
Exact mass
455.1553 Dacalc.
LogP (octanol/water)
-0.02calc.
Topological polar surface area
204.5 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
9calc.
Rotatable bonds
9calc.
Heavy atoms
33calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]cnc2ncc(CNc3ccccc3)nc12

O=c1[nH]cnc2ncc(CNc3ccccc3)nc12

3 rings, 19 atoms.

106 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H341Suspected of causing genetic defects.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (17)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methopterin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers

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Where suppliers are based

3 suppliers in 3 countries

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Methopterin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Applications are not documented for this substance yet. Suppliers often describe uses on their product pages, linked in the suppliers list above.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methopterin is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methopterin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methopterin, based on the data on this page

What is Methopterin?

Methopterine is a member of folic acids.

What is the CAS number of Methopterin?

The CAS registry number of Methopterin is 2410-93-7.

What is the molecular formula and weight of Methopterin?

The molecular formula of Methopterin is C20H21N7O6 and its molar mass is 455.43 g/mol.

Is Methopterin hazardous?

Methopterin carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methopterin?

Methopterin is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methopterin?

CompoundList lists 3 suppliers of Methopterin in China, Czech Republic and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Methopterin?

Suppliers quote Methopterin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methopterin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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