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Antibiotics and anti-infectives

Fosamprenavir

Also known as FOS-APV, fos-amprenavir, VX 175

CAS 226700-79-4Formula C25H36N3O9PSMolar mass 585.62 g/mol
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Fosamprenavir chemical structure, C25H36N3O9PS, CAS 226700-79-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
226700-79-4
Formula
C25H36N3O9PS
Molar mass
585.62 g/mol
Solubility
White to cream colored solid. Solubility in water is approximately 0.31 mg/mL at 25 °C /…
HS code
293590
Category
Antibiotics and anti-infectives

What is Fosamprenavir?

Plain description, key identifiers and synonyms

Fosamprenavir is a sulfonamide with a structure based on that of sulfanilamide substituted on the sulfonamide nitrogen by a (2R,3S)-4-phenyl-2-(phosphonooxy)-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butyl group. It is a pro-drug of the HIV protease inhibitor and antiretroviral drug amprenavir. It has a role as a prodrug. It is functionally related to a sulfanilamide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonooxybutan-2-yl]carbamate
CAS number
226700-79-4 CAS number cross-checkedOther or deprecated CAS: 1257693-05-2
Molecular formula
C25H36N3O9PS
UNII
WOU1621EEG
MDL number
MFCD09955118
InChIKey
MLBVMOWEQCZNCC-OEMFJLHTSA-N
InChI
InChI=1S/C25H36N3O9PS/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32)/t21-,23-,24+/m0/s1
Canonical SMILES
CC(C)CN(CC(OP(=O)(O)O)C(Cc1ccccc1)NC(=O)OC1CCOC1)S(=O)(=O)c1ccc(N)cc1
Isomeric SMILES
CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CCOC2)OP(=O)(O)O)S(=O)(=O)C3=CC=C(C=C3)N

Synonyms

  • FOS-APV
  • fos-amprenavir
  • VX 175
  • [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonooxybutan-2-yl]carbamate
  • GW 433908
  • (3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic acid C-(tetrahydro-3-furanyl) ester
  • GW 908
  • fosamprenavirum
  • (((2R,3S)-1-(N-(2-methylpropyl)(4-aminobenzene)sulfonamido)-3-((((3S)-oxolan-3-yloxy)carbonyl)amino)-4-phenylbutan-2-yl)oxy)phosphonic acid
  • ((3S)-oxolan-3-yl) N-((2S,3R)-4-((4-aminophenyl)sulfonyl-(2-methylpropyl)amino)-1-phenyl-3-phosphonooxybutan-2-yl)carbamate
  • {[(2R,3S)-1-[N-(2-methylpropyl)(4-aminobenzene)sulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid
  • Fosamprenavir (INN)
  • [(3S)-tetrahydrofuran-3-yl] N-[(1S,2R)-3-[(4-aminophenyl)sulfonyl-isobutyl-amino]-1-benzyl-2-phosphonooxy-propyl]carbamate
  • Amprenavir phosphate
  • Telzir(TM)
  • (S)-Tetrahydrofuran-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate
  • Lexiva (TM)
  • (3S)-Oxolan-3-yl [(2S,3R)-4-[4-amino-N-(2-methylpropyl)benzene-1-sulfonamido]-1-phenyl-3-(phosphonooxy)butan-2-yl]carbamate
  • GW433908A (*Sodium Salt*)
  • GW433908G (*Calcium Salt*)
  • GW908 cpd
  • VX175 cpd
  • Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)-, C-((3S)-tetrahydro-3-furanyl) ester
  • ((3S)Oxolan-3-yloxy)-N-((1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-benzyl-2-(phosphonooxy)propyl)carboxamide
  • (3S)-Tetrahydro-3-furyl ((.alpha.s)-alpha-((1R)-1-hydroxy-2-(n1-isobutylsulfanilamido)ethyl)phenethyl)carbamate phosphate (ester)
Show all 30 synonyms
  • (3S)-tetrahydrofuran-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-phenyl-3-(phosphonooxy)butan-2-yl]carbamate
  • {[(2R,3S)-1-[N-(2-methylpropyl)-4-aminobenzenesulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid
  • Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)-, c-(3S)-tetrahydro-3-furanyl) ester
  • N-[3-[N-(4-aminophenylsulfonyl)-N-isobutylamino]-1(s)-benzyl-2(r)-(phosphonooxyl)propyl]carbamic acid tetrahydrofuran-3(s)-yl ester
  • rel-(3R)-Tetrahydro-3-furanyl N-[(1R,2S)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]carbamate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
White to cream colored solid. Solubility in water is approximately 0.31 mg/mL at 25 °C /Calcium salt/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
585.62 g/molcalc.
Exact mass
585.191 Dacalc.
LogP (octanol/water)
2.52calc.
Topological polar surface area
177.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
13calc.
Heavy atoms
39calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.48calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NC(CCNS(=O)(=O)c1ccccc1)Cc1ccccc1)OC1CCOC1

O=C(NC(CCNS(=O)(=O)c1ccccc1)Cc1ccccc1)OC1CCOC1

3 rings, 29 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Fosamprenavir suppliers

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All 3 suppliers

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Where suppliers are based

3 suppliers in 2 countries

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Fosamprenavir price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antiviral (systemic).

Industries and functions

Pharmacological actions

  • Anti-HIV Agents
  • HIV Protease Inhibitors

Roles

  • anti-HIV agent
  • antimicrobial agent
  • antiviral agent
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Fosamprenavir is a Protease Inhibitor. The mechanism of action of fosamprenavir is as a HIV Protease Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fosamprenavir is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Fosamprenavir is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fosamprenavir, based on the data on this page

What is Fosamprenavir?

Fosamprenavir is a sulfonamide with a structure based on that of sulfanilamide substituted on the sulfonamide nitrogen by a (2R,3S)-4-phenyl-2-(phosphonooxy)-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butyl group. It is a pro-drug of the HIV protease inhibitor and antiretroviral drug amprenavir.

What is the CAS number of Fosamprenavir?

The CAS registry number of Fosamprenavir is 226700-79-4. Other or deprecated CAS numbers: 1257693-05-2.

What is the molecular formula and weight of Fosamprenavir?

The molecular formula of Fosamprenavir is C25H36N3O9PS and its molar mass is 585.62 g/mol.

What is Fosamprenavir used for?

Antiviral (systemic).

Is Fosamprenavir hazardous?

No GHS hazard classification for Fosamprenavir is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Fosamprenavir?

Fosamprenavir is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fosamprenavir?

CompoundList lists 3 suppliers of Fosamprenavir in India and China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Fosamprenavir in India?

2 suppliers in India list Fosamprenavir on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Fosamprenavir?

Suppliers quote Fosamprenavir on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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