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Screening compounds

Fosbretabulin

Also known as Combretastatin A-4 phosphate, Phosbretabulin, combretastatin A4 phosphate

CAS 222030-63-9Formula C18H21O8PMolar mass 396.33 g/mol
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Fosbretabulin chemical structure, C18H21O8P, CAS 222030-63-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
222030-63-9
Formula
C18H21O8P
Molar mass
396.33 g/mol
HS code
291990
Category
Screening compounds

What is Fosbretabulin?

Plain description, key identifiers and synonyms

Fosbretabulin is a water-soluble prodrug derived from the African bush willow (Combretum caffrum) with antineoplastic activity. Fosbretabulin is dephosphorylated to its active metabolite, combretastatin A4, which binds to tubulin and inhibits microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse, the acute disruption of tumor blood flow may result in tumor necrosis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate
CAS number
222030-63-9 CAS number cross-checked
Molecular formula
C18H21O8P
UNII
I5590ES2QZ
InChIKey
WDOGQTQEKVLZIJ-WAYWQWQTSA-N
InChI
InChI=1S/C18H21O8P/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3/h5-11H,1-4H3,(H2,19,20,21)/b6-5-
Canonical SMILES
COc1ccc(C=Cc2cc(OC)c(OC)c(OC)c2)cc1OP(=O)(O)O
Isomeric SMILES
COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)(O)O

Synonyms

  • Combretastatin A-4 phosphate
  • Phosbretabulin
  • combretastatin A4 phosphate
  • fosbretabulina
  • fosbretabuline
  • [2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate
  • Phenol, 2-methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, dihydrogen phosphate
  • 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenyl phosphate
  • 2-methoxy-5-((z)-2-(3,4,5-trimethoxyphenyl)vinyl)phenyl dihydrogen phosphate
  • phenol, 2-methoxy-5-((1z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-,1-(dihydrogen phosphate)
  • phenol, 2-methoxy-5-((z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, dihydrogen phosphate
  • fosbretabulinum
  • (2-methoxy-5-((Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenoxy)phosphonic acid
  • (2-methoxy-5-((Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)phenyl) dihydrogen phosphate
  • [2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenoxy]phosphonic acid
  • (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenyl dihydrogen phosphate
  • CA 4DP
  • Fosbretabulin free acid
  • 222030-63-9 (free acid)
  • Combretastatin A-4P
  • Fosbretabulin [free base]
  • Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-,dihydrogen phosphate
  • Zybrestat (fosbretabulin disodium)
  • (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenyldihydrogenphosphate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
396.33 g/molcalc.
Exact mass
396.0974 Dacalc.
LogP (octanol/water)
3.36calc.
Topological polar surface area
103.7 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
8calc.
Heavy atoms
27calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.22calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C(=Cc1ccccc1)c1ccccc1

C(=Cc1ccccc1)c1ccccc1

2 rings, 14 atoms, the Stilbene ring system.

2,005 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Fosbretabulin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Fosbretabulin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents, Phytogenic

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fosbretabulin is traded under.

HS 2919.90Indicative HS code

Phosphoric, and their salts, including lactophosphates, their halogenated, sulphonated, nitrated…

World exports in 2024
$940M
−0.7% vs 2023, imports $863M
2019 to 2024
Top exporters
  1. China55.6%
  2. Germany10.6%
  3. Italy6.2%
Top importers
  1. United States15.8%
  2. South Korea10.1%
  3. Germany6.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Fosbretabulin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fosbretabulin, based on the data on this page

What is Fosbretabulin?

Fosbretabulin is a water-soluble prodrug derived from the African bush willow (Combretum caffrum) with antineoplastic activity.

What is the CAS number of Fosbretabulin?

The CAS registry number of Fosbretabulin is 222030-63-9.

What is the molecular formula and weight of Fosbretabulin?

The molecular formula of Fosbretabulin is C18H21O8P and its molar mass is 396.33 g/mol.

What is Fosbretabulin used for?

Known uses and roles of Fosbretabulin include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, pharmaceutical and antineoplastic agents, phytogenic.

Is Fosbretabulin hazardous?

No GHS hazard classification for Fosbretabulin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Fosbretabulin?

Fosbretabulin is usually classified under HS code 291990 (Phosphoric esters and their salts, including lactophosphates, their halogenated…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fosbretabulin?

CompoundList lists 2 suppliers of Fosbretabulin in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Fosbretabulin?

Suppliers quote Fosbretabulin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fosbretabulin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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