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Screening compounds

Gemigliptin

Also known as Gemigliptina, Gemigliptine, 2-Piperidinone, 1-((2S)-2-amino-4-(5,8-dihydro-2,4-bis(trifluoromethyl)pyrido(3,4-d)pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoro-

CAS 911637-19-9Formula C18H19F8N5O2Molar mass 489.37 g/mol
6 suppliers listed
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Gemigliptin chemical structure, C18H19F8N5O2, CAS 911637-19-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
911637-19-9
Formula
C18H19F8N5O2
Molar mass
489.37 g/mol
HS code
293359
Category
Screening compounds

What is Gemigliptin?

Plain description, key identifiers and synonyms

Gemigliptin is an organonitrogen compound and an organooxygen compound. It is functionally related to a beta-amino acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
CAS number
911637-19-9 CAS number cross-checked
Molecular formula
C18H19F8N5O2
UNII
5DHU18M5D6
MDL number
MFCD19443742
InChIKey
ZWPRRQZNBDYKLH-VIFPVBQESA-N
InChI
InChI=1S/C18H19F8N5O2/c19-16(20)3-1-12(32)31(8-16)6-9(27)5-13(33)30-4-2-10-11(7-30)28-15(18(24,25)26)29-14(10)17(21,22)23/h9H,1-8,27H2/t9-/m0/s1
Canonical SMILES
NC(CC(=O)N1CCc2c(nc(C(F)(F)F)nc2C(F)(F)F)C1)CN1CC(F)(F)CCC1=O
Isomeric SMILES
C1CC(CN(C1=O)C[C@H](CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F)N)(F)F

Synonyms

  • Gemigliptina
  • Gemigliptine
  • 2-Piperidinone, 1-((2S)-2-amino-4-(5,8-dihydro-2,4-bis(trifluoromethyl)pyrido(3,4-d)pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoro-
  • Pyrido(3,4-d)pyrimidine, 7-((3S)-3-amino-4-(5,5-difluoro-2-oxo-1-piperidinyl)-1-oxobutyl)-5,6,7,8-tetrahydro-2,4-bis(trifluoromethyl)-
  • 1-((2S)-2-Amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido(3,4-d)pyrimidin-7(6H)-yl)-4-oxobutyl-5,5-difluoropiperidin-2-one
  • gemigliptinum
  • 1-((2S)-2-amino-4-(2,4-bis(trifluoromethyl)-5H,6H,7H,8H-pyrido(3,4-d)pyrimidin-7-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one
  • Gemigliptin Hydrochloride
  • (S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one
  • Gemigliptin (INN)
  • 1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
  • (S)-1-(2-Amino-4-(2,4-bis(trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one
  • 1-[(2S)-2-Amino-4-[5,8-dihydro-2,4-bis(trifluoromethyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl]-5,5-difluoro-2-piperidinone
  • 1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxo-butyl]-5,5-difluoro-piperidin-2-one
  • Gemigliptin?
  • 911637-19-9 (free base)
  • US20240115577, Compound 11
  • (S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8- dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4- oxobutyl)-5,5-difluoropiperidin-2-one (Gemigliptin)
  • 1-((2S)-2-Amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido(3,4-d)pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
489.37 g/molcalc.
Exact mass
489.1411 Dacalc.
LogP (octanol/water)
2.37calc.
Topological polar surface area
92.42 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
33calc.
Rings
3calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CCCCN1CCCC(=O)N1CCc2cncnc2C1

O=C1CCCCN1CCCC(=O)N1CCc2cncnc2C1

3 rings, 22 atoms.

7 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Gemigliptin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 3 countries

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Gemigliptin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • hypoglycemic agent
  • pharmaceutical
  • protective agent
  • renoprotective agent

Pharmacology

Gemigliptin is an orally bioavailable inhibitor of the serine protease dipeptidyl peptidase 4 (DPP-4), with hypoglycemic and potential renoprotective activities. Upon administration, gemigliptin binds to DPP-4 and inhibits the breakdown of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This prolongs incretin activity, increases postprandial insulin secretion from pancreatic beta cells, decreases glucagon secretion, delays gastric emptying and lowers blood glucose levels. In addition, gemigliptin exerts a renoprotective effect, probably through enhanced GLP-1 signaling, may prevent apoptosis and acute kidney injury induced by nephrotoxic agents, and may protect against diabetic nephropathy.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Gemigliptin is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Gemigliptin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Gemigliptin, based on the data on this page

What is Gemigliptin?

Gemigliptin is an organonitrogen compound and an organooxygen compound. It is functionally related to a beta-amino acid.

What is the CAS number of Gemigliptin?

The CAS registry number of Gemigliptin is 911637-19-9.

What is the molecular formula and weight of Gemigliptin?

The molecular formula of Gemigliptin is C18H19F8N5O2 and its molar mass is 489.37 g/mol.

What is Gemigliptin used for?

Known uses and roles of Gemigliptin include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, hypoglycemic agent, pharmaceutical and 2 more.

Is Gemigliptin hazardous?

No GHS hazard classification for Gemigliptin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Gemigliptin?

Gemigliptin is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Gemigliptin?

CompoundList lists 6 suppliers of Gemigliptin in United States, India and Singapore. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Gemigliptin in India?

2 suppliers in India list Gemigliptin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Gemigliptin?

Suppliers quote Gemigliptin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Gemigliptin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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