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Humectants

Glycolide

Also known as Glycollide, p-Dioxane-2,5-dione, 1,4-Dioxane-2,5-dione

CAS 502-97-6Formula C4H4O4Molar mass 116.07 g/molEC 207-954-9
GHS signal word: Warning. Pictograms: Harmful or irritant 6 suppliers listed
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Glycolide chemical structure, C4H4O4, CAS 502-97-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
502-97-6
Formula
C4H4O4
Molar mass
116.07 g/mol
Physical form
Crystals
HS code
293220
Category
Humectants
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Glycolide?

Plain description, key identifiers and synonyms

Glycolide is a chemical substance with the molecular formula C4H4O4 and a molar mass of 116.07 g/mol. Its CAS registry number is 502-97-6. The IUPAC name is 1,4-dioxane-2,5-dione.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,4-dioxane-2,5-dione
CAS number
502-97-6 CAS number cross-checkedOther or deprecated CAS: 26202-08-4
EC number
207-954-9
Molecular formula
C4H4O4
UNII
YRZ676PGU6
MDL number
MFCD00081108
INCI name
GLYCOLIDE
InChIKey
RKDVKSZUMVYZHH-UHFFFAOYSA-N
InChI
InChI=1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2
SMILES (canonical and isomeric)
C1C(=O)OCC(=O)O1

Synonyms

  • Glycollide
  • p-Dioxane-2,5-dione
  • 1,4-Dioxane-2,5-dione
  • 1,4-Dioxan-2,5-dione
  • Glycolide S, Glycollide, Glycolide
  • 2,5-dioxo-1,4-dioxane
  • Glycolide,99.9%
  • Glycolide, >=99%
  • Acetic acid, bimol. cyclic ester
  • Acetic acid, hydroxy-, bimol. cyclic ester

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Crystalsexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
116.07 g/molcalc.
Exact mass
116.011 Dacalc.
LogP (octanol/water)
-0.91calc.
Topological polar surface area
52.6 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
8calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1COC(=O)CO1

O=C1COC(=O)CO1

1 ring, 8 atoms. This chemical is the scaffold itself.

31 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P330Rinse mouth.
  • P337 + P317If eye irritation persists: Get medical help.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Glycolide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 3 countries

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Glycolide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Industrial uses: Monomers.

Cosmetic ingredient, INCI name GLYCOLIDE(humectant, skin conditioning)

Functional uses

  • Humectant
  • Softener and conditioner

Cosmetic functions

  • Humectant
  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce, Regulatory flags: Added by a premanufacture notice

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Glycolide is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Glycolide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Glycolide, based on the data on this page

What is Glycolide?

Glycolide is a chemical substance with the molecular formula C4H4O4 and a molar mass of 116.07 g/mol. Its CAS registry number is 502-97-6. The IUPAC name is 1,4-dioxane-2,5-dione.

What is the CAS number of Glycolide?

The CAS registry number of Glycolide is 502-97-6. Other or deprecated CAS numbers: 26202-08-4.

What is the molecular formula and weight of Glycolide?

The molecular formula of Glycolide is C4H4O4 and its molar mass is 116.07 g/mol.

What is Glycolide used for?

Industrial uses: Monomers.

Is Glycolide hazardous?

Glycolide carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Glycolide?

Glycolide is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Glycolide?

CompoundList lists 6 suppliers of Glycolide in United States, China and India. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Glycolide in India?

1 supplier in India list Glycolide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Glycolide?

Suppliers quote Glycolide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Glycolide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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