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Alkaloids

Guvacine

Also known as 1,2,5,6-tetrahydropyridine-3-carboxylic acid, 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid, 1,2,5,6-Tetrahydronicotinic acid

CAS 498-96-4Formula C6H9NO2Molar mass 127.14 g/mol
4 suppliers listed
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Guvacine chemical structure, C6H9NO2, CAS 498-96-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
498-96-4
Formula
C6H9NO2
Molar mass
127.14 g/mol
HS code
293979
Category
Alkaloids

What is Guvacine?

Plain description, key identifiers and synonyms

Guvacine is a alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring. It has a role as a plant metabolite and a GABA reuptake inhibitor. It is a pyridine alkaloid, a tetrahydropyridine, a beta-amino acid, a secondary amino compound and an alpha,beta-unsaturated monocarboxylic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,2,3,6-tetrahydropyridine-5-carboxylic acid
CAS number
498-96-4 CAS number cross-checked
Molecular formula
C6H9NO2
UNII
41538P325K
MDL number
MFCD01365700
InChIKey
QTDZOWFRBNTPQR-UHFFFAOYSA-N
InChI
InChI=1S/C6H9NO2/c8-6(9)5-2-1-3-7-4-5/h2,7H,1,3-4H2,(H,8,9)
SMILES (canonical and isomeric)
C1CNCC(=C1)C(=O)O

Synonyms

  • 1,2,5,6-tetrahydropyridine-3-carboxylic acid
  • 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid
  • 1,2,5,6-Tetrahydronicotinic acid
  • 1,2,3,6-tetrahydropyridine-5-carboxylic acid
  • 1,2,3,6-tetrahydropyridin-1-ium-5-carboxylate
  • 1,2,5,6-Tetrahydro-pyridine-3-carboxylic acid
  • Tocris-0234
  • Biomol-NT_000253
  • DivK1c_006904
  • Sdccgmls-0066665.p001
  • Sdccgsbi-0050553.p003
  • 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
127.14 g/molcalc.
Exact mass
127.0633 Dacalc.
LogP (octanol/water)
-0.01calc.
Topological polar surface area
49.33 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
9calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.5calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=CCNCC1

C1=CCNCC1

1 ring, 6 atoms, the 1,2,3,6-Tetrahydropyridine ring system.

987 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Guvacine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 4 suppliers
4 of 4 offers
  • ChemFaces
    China, WuhanUnclaimed profile
    GuvacineGrade, purity and minimum order on request
    Price on request
    View
  • EDASA Scientific
    Russia, MoscowUnclaimed profile
    GuvacineGrade, purity and minimum order on request
    Price on request
    View
  • J&W PharmLab, LLC
    United States, LevittownUnclaimed profile
    GuvacineGrade, purity and minimum order on request
    Price on request
    View
  • Synblock Inc
    Canada, MontrealUnclaimed profile
    GuvacineGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

4 suppliers in 4 countries

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Guvacine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • GABA reuptake inhibitor
  • eukaryotic metabolite
  • metabolite
  • neurotransmitter agent
  • pharmaceutical
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Guvacine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Guvacine is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Guvacine, based on the data on this page

What is Guvacine?

Guvacine is a alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring. It has a role as a plant metabolite and a GABA reuptake inhibitor.

What is the CAS number of Guvacine?

The CAS registry number of Guvacine is 498-96-4.

What is the molecular formula and weight of Guvacine?

The molecular formula of Guvacine is C6H9NO2 and its molar mass is 127.14 g/mol.

What is Guvacine used for?

Known uses and roles of Guvacine include gaba reuptake inhibitor, eukaryotic metabolite, metabolite, neurotransmitter agent, pharmaceutical and 1 more.

Is Guvacine hazardous?

No GHS hazard classification for Guvacine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Guvacine?

Guvacine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Guvacine?

CompoundList lists 4 suppliers of Guvacine in Canada, China, Russia and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Guvacine?

Suppliers quote Guvacine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Guvacine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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