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Halofuginone

Also known as Halofuginonum, Halocur, Halofunginone

CAS 55837-20-2Formula C16H17BrClN3O3Molar mass 414.69 g/mol
10 suppliers listed
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Halofuginone chemical structure, C16H17BrClN3O3, CAS 55837-20-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
55837-20-2
Formula
C16H17BrClN3O3
Molar mass
414.69 g/mol
HS code
293359
Category
Feed additives

What is Halofuginone?

Plain description, key identifiers and synonyms

Halofuginone is an orally-active quinazolinone alkaloid with potential antineoplastic activity. Halofuginone interferes with the signaling pathway of transforming growth factor beta (TGF beta) and inhibits expression of matrix metalloproteinase 2, thereby inhibiting collagen type I synthesis and inducing extracellular matrix degradation, resulting in inhibition of angiogenesis, tumor growth, or metastasis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one
CAS number
55837-20-2 CAS number cross-checkedOther or deprecated CAS: 7695-84-3, 868851-54-1
Molecular formula
C16H17BrClN3O3
UNII
H84E4Y7HC9, L31MM1385E
MDL number
MFCD09834143
InChIKey
LVASCWIMLIKXLA-CABCVRRESA-N
InChI
InChI=1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2/t14-,15+/m1/s1
Canonical SMILES
O=C(CC1NCCCC1O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Isomeric SMILES
C1C[C@@H]([C@H](NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O

Synonyms

  • Halofuginonum
  • Halocur
  • Halofunginone
  • Halofuginon
  • 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one
  • Halofuginone HCl
  • 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one
  • 7-bromo-6-chloro-3-(3-((2R,3S)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4-one
  • 7-bromo-6-chloro-3-(3-((2R,3S)-3-hydroxypiperidin-2-yl)-2-oxopropyl)-3,4-dihydroquinazolin-4-one
  • halofuginone monohydrobromide
  • 7-bromo-6-chlorofebrifugine
  • halofuginone monohydrochloride
  • 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone
  • (+-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone
  • trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone
  • 7-bromo-6-chloro-3-(3-(3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4-one
  • Halofuginona
  • (+)-Halofuginone
  • Halofuginone, (+)-
  • 7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-Quinazolinone
  • 6-Chloro-7-bromo-(+)-febrifugine
  • (+/-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone
  • C16H17BrClN3O3
  • rel-7-Bromo-6-chloro-3-(3-((2R,3S)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one
  • 7-Bromo-6-chloro-3-(3-((2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-4(3H)-quinazolinone
Show all 33 synonyms
  • 7-Bromo-6-chloro-3-(3-((2R,3S)-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one
  • 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one
  • 7-Bromo-6-Chloro-3-{3-[(2r,3s)-3-Hydroxypiperidin-2-Yl]-2-Oxopropyl}quinazolin-4(3h)-One
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-((2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-
  • HalocurTM
  • HFG
  • (+-)-trans-7-Brom-6-chlor-3-(3-(3-hydroxy-2-piperidyl)acetonyl-4(3H)-chinazolinon
  • (+-)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)acetonyl-4(3H)-quinazolinone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
414.69 g/molcalc.
Exact mass
413.0142 Dacalc.
LogP (octanol/water)
1.88calc.
Topological polar surface area
84.22 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.44calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CC1CCCCN1)Cn1cnc2ccccc2c1=O

O=C(CC1CCCCN1)Cn1cnc2ccccc2c1=O

3 rings, 21 atoms.

21 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Halofuginone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 10 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

10 suppliers in 3 countries

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Halofuginone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Angiogenesis Inhibitors
  • Antineoplastic Agents
  • Coccidiostats
  • Protein Synthesis Inhibitors

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Halofuginone is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Halofuginone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Halofuginone, based on the data on this page

What is Halofuginone?

Halofuginone is an orally-active quinazolinone alkaloid with potential antineoplastic activity.

What is the CAS number of Halofuginone?

The CAS registry number of Halofuginone is 55837-20-2. Other or deprecated CAS numbers: 7695-84-3, 868851-54-1.

What is the molecular formula and weight of Halofuginone?

The molecular formula of Halofuginone is C16H17BrClN3O3 and its molar mass is 414.69 g/mol.

What is Halofuginone used for?

Known uses and roles of Halofuginone include coccidiostats in animal feed and nutrition, angiogenesis inhibitors, antineoplastic agents, coccidiostats and protein synthesis inhibitors.

Is Halofuginone hazardous?

No GHS hazard classification for Halofuginone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Halofuginone?

Halofuginone is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Halofuginone?

CompoundList lists 10 suppliers of Halofuginone in China, India and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Halofuginone in India?

1 supplier in India list Halofuginone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Halofuginone?

Suppliers quote Halofuginone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Halofuginone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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