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Screening compounds

Halofuginone hydrobromide

Also known as Halofuginone HBr, Stenorol, Tempostatin

CAS 64924-67-0Formula C16H18Br2ClN3O3Molar mass 495.60 g/molEC 694-602-6
GHS signal word: Warning. Pictograms: Harmful or irritant 7 suppliers listed
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Halofuginone hydrobromide chemical structure, C16H18Br2ClN3O3, CAS 64924-67-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
64924-67-0
Formula
C16H18Br2ClN3O3
Molar mass
495.60 g/mol
EC number
694-602-6
HS code
293359
Category
Screening compounds

What is Halofuginone hydrobromide?

Plain description, key identifiers and synonyms

Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one, hydrobromide
CAS number
64924-67-0 CAS number cross-checkedOther or deprecated CAS: 57426-42-3
EC number
694-602-6
Molecular formula
C16H18Br2ClN3O3
UNII
PTC2969MV1
MDL number
MFCD00946455
InChIKey
SJUWEPZBTXEUMU-LIOBNPLQSA-N
InChI
InChI=1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H/t14-,15+;/m1./s1
Canonical SMILES
Br.O=C(CC1NCCCC1O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Isomeric SMILES
C1C[C@@H]([C@H](NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br

Synonyms

  • Halofuginone HBr
  • Stenorol
  • Tempostatin
  • Ru 19110
  • (+-)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide
  • Halofuginone IV (intravenous)
  • Stenorol Type A Medicated Article
  • 7-Bromo-6-chloro-3-(3-((2S,3R)-rel-3-hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide
  • (+/-)-trans-7-Bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohydrobromide
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+/-)-
  • 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl]quinazolin-4-one, hydrobromide
  • C16H18Br2ClN3O3
  • RU-19110 (hydrobromide)
  • Halofuginonehydrobromide
  • (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-
  • (+/-)-Trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone monohbr
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(2R,3S)-3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide, rel-
  • 4(3H)-quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hbr, trans-(+/-)-
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, hydrobromide, trans-(+-)-
  • 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, hydrobromide (1:1)
  • 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxo-propyl]quinazolin-4-one, hydrobromide
  • 7-Bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one--hydrogen bromide (1/1)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
495.60 g/molcalc.
Exact mass
492.9403 Dacalc.
LogP (octanol/water)
2.46calc.
Topological polar surface area
84.22 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
25calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.44calc.
Formal charge
0calc.
Stereocentres
2calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CC1CCCCN1)Cn1cnc2ccccc2c1=O

O=C(CC1CCCCN1)Cn1cnc2ccccc2c1=O

3 rings, 21 atoms.

21 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Halofuginone hydrobromide suppliers

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Where suppliers are based

7 suppliers in 3 countries

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Halofuginone hydrobromide price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Halofuginone hydrobromide is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Halofuginone hydrobromide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Halofuginone hydrobromide, based on the data on this page

What is Halofuginone hydrobromide?

Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities.

What is the CAS number of Halofuginone hydrobromide?

The CAS registry number of Halofuginone hydrobromide is 64924-67-0. Other or deprecated CAS numbers: 57426-42-3.

What is the molecular formula and weight of Halofuginone hydrobromide?

The molecular formula of Halofuginone hydrobromide is C16H18Br2ClN3O3 and its molar mass is 495.60 g/mol.

What is Halofuginone hydrobromide used for?

Use classes: Animal Drugs.

Is Halofuginone hydrobromide hazardous?

Halofuginone hydrobromide carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Halofuginone hydrobromide?

Halofuginone hydrobromide is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Halofuginone hydrobromide?

CompoundList lists 7 suppliers of Halofuginone hydrobromide in China, Bulgaria and Ukraine. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Halofuginone hydrobromide?

Suppliers quote Halofuginone hydrobromide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Halofuginone hydrobromide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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