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Central nervous system drugs

Haloperidol

Also known as Serenace, Aloperidin, Eukystol

CAS 52-86-8Formula C21H23ClFNO2Molar mass 375.87 g/molEC 200-155-6
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 138 suppliers listed Drug substance
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Haloperidol chemical structure, C21H23ClFNO2, CAS 52-86-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
151.5 °C
Solubility
Crystals, mp 226-227.5 °C, sol in water at 300 × 10⁺¹ mg/L /Hydrochloride/
HS code
293339
Category
Central nervous system drugs
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Haloperidol?

Plain description, key identifiers and synonyms

Haloperidol is a compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. It has a role as a serotonergic antagonist, a dopaminergic antagonist, an antiemetic, a first generation antipsychotic and an antidyskinesia agent. It is a tertiary alcohol, an organofluorine compound, a hydroxypiperidine, an aromatic ketone and a member of monochlorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
CAS number
52-86-8 CAS number cross-checkedOther or deprecated CAS: 177716-59-5
EC number
200-155-6
Molecular formula
C21H23ClFNO2
UNII
J6292F8L3D
MDL number
MFCD00051423
InChIKey
LNEPOXFFQSENCJ-UHFFFAOYSA-N
InChI
InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
SMILES (canonical and isomeric)
C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F

Synonyms

  • Serenace
  • Aloperidin
  • Eukystol
  • Serenase
  • Serenelfi
  • Linton
  • Aloperidolo
  • Galoperidol
  • Halopoidol
  • Brotopon
  • Halopal
  • Keselan
  • Ulcolind
  • Uliolind
  • Dozic
  • Pernox
  • Sernas
  • Sernel
  • Aldo
  • Einalon S
  • Sigaperidol
  • Peluces
  • Bioperidolo
  • Halosten
  • Haldol Solutab
Show all 39 synonyms
  • 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
  • Haloperidolum
  • Fortunan
  • McN-JR-1625
  • 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
  • 4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone
  • 1-(3-p-Fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine
  • 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
  • 4'-Fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone
  • 4'-Fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
  • 4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
  • 1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-
  • 4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone
  • 4-(4-(para-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
151.5 °Cexp.
Solubility
Crystals, mp 226-227.5 °C, sol in water at 300 × 10⁺¹ mg/L /Hydrochloride/exp.
Vapour pressure
4.8 × 10⁻¹¹ mm Hg @ 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
375.87 g/molcalc.
Exact mass
375.1401 Dacalc.
LogP (octanol/water)
4.43calc.
Topological polar surface area
40.54 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
26calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.38calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCCN1CCC(c2ccccc2)CC1)c1ccccc1

O=C(CCCN1CCC(c2ccccc2)CC1)c1ccccc1

3 rings, 23 atoms.

60 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (23)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Haloperidol suppliers

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All 138 suppliers
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Where suppliers are based

138 suppliers in 26 countries

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Haloperidol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Medication: Antidyskinetic (in Gilles de la Tourette's disease), antipsychotic.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Anti-Dyskinesia Agents
  • Antiemetics
  • Antipsychotic Agents
  • Dopamine Antagonists

Roles

  • analgesic
  • antagonist
  • antidepressant
  • antidyskinesia agent
  • antiemetic
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Haloperidol is a Typical Antipsychotic.

How it is made

/Condensation of/ 4-(p-chlorophenyl)-4-piperidinol ... With 4-chloro-4'-fluorobutyrophenone by heating toluene solution of reactants in presence of suitable condensing agent. ... Isolation from reaction mixture & recrystallization from suitable solvent ... (Diisopropyl ether).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Haloperidol (INN), Ref no: 185, Annex ref: II/185
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Haloperidol is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Haloperidol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Haloperidol, based on the data on this page

What is Haloperidol?

Haloperidol is a compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. It has a role as a serotonergic antagonist, a dopaminergic antagonist, an antiemetic, a first generation antipsychotic and an antidyskinesia agent.

What is the CAS number of Haloperidol?

The CAS registry number of Haloperidol is 52-86-8. Other or deprecated CAS numbers: 177716-59-5.

What is the molecular formula and weight of Haloperidol?

The molecular formula of Haloperidol is C21H23ClFNO2 and its molar mass is 375.87 g/mol.

What is Haloperidol used for?

Veterinary medication:. Medication: Antidyskinetic (in Gilles de la Tourette's disease), antipsychotic. Use classes: Pharmaceuticals.

Is Haloperidol hazardous?

Haloperidol carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Haloperidol?

Haloperidol is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Haloperidol?

CompoundList lists 138 suppliers of Haloperidol in United States, China, India, United Kingdom and 22 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Haloperidol in India?

21 suppliers in India list Haloperidol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Haloperidol?

Suppliers quote Haloperidol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Haloperidol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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