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Dyes and pigments

Hematoxylin

Also known as Haematoxylin, Hydroxybrazilin, Hydroxybrasilin

CAS 517-28-2Formula C16H14O6Molar mass 302.28 g/molEC 208-237-3
GHS signal word: Warning. Pictograms: Harmful or irritant 79 suppliers listed
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Hematoxylin chemical structure, C16H14O6, CAS 517-28-2
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Crystals
Melting point
100 to 120
Solubility
Slightly soluble in cold, soluble in hot
HS code
293299
Category
Dyes and pigments
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Hematoxylin?

Plain description, key identifiers and synonyms

(+)-haematoxylin is a haematoxylin. It is an enantiomer of a (-)-haematoxylin.

Hematoxylin is a chemical compound used as a histologic stain and historically as a blue and black dye for textiles.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6aS,11bR)-7,11b-dihydro-6H-indeno[2,1-c]chromene-3,4,6a,9,10-pentol
CAS number
517-28-2 CAS number cross-checkedOther or deprecated CAS: 1412-19-7, 1621-46-1, 8005-33-2
EC number
208-237-3
Molecular formula
C16H14O6
UNII
YKM8PY2Z55
MDL number
MFCD00078111
INCI name
HAEMATOXYLUM CAMPECHIANUM WOOD EXTRACT
InChIKey
WZUVPPKBWHMQCE-XJKSGUPXSA-N
InChI
InChI=1S/C16H14O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,13,17-21H,5-6H2/t13-,16+/m0/s1
Canonical SMILES
Oc1cc2c(cc1O)C1c3ccc(O)c(O)c3OCC1(O)C2
Isomeric SMILES
C1C2=CC(=C(C=C2[C@H]3[C@@]1(COC4=C3C=CC(=C4O)O)O)O)O

Synonyms

  • Haematoxylin
  • Hydroxybrazilin
  • Hydroxybrasilin
  • Natural Black 1
  • (+)-Hematoxylin
  • Hydroxylrasilin
  • (6aS,11bR)-7,11b-dihydro-6H-indeno[2,1-c]chromene-3,4,6a,9,10-pentol
  • Benz(b)indeno(1,2-d)pyran-3,4,6a,9,10(6H)-pentol, 7,11b-dihydro-, cis-(+)-
  • hematoxiline
  • C.I. 75290
  • Hemotoxylin
  • cis-(+)-7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,4,6a,9,10(6H)-pentol
  • (6aS,11bR)-7,11b-dihydro-6H-indeno(2,1-c)chromene-3,4,6a,9,10-pentol
  • cis-(+)-7,11b-dihydrobenz(b)indeno(1,2-d)pyran-3,4,6a,9,10(6H)-pentol
  • 7,11b-dihydro-6H-indeno(2,1-c)chromene-3,4,6a,9,10-pentol
  • Benz(b)indeno(1,2-d)pyran-3,4,6a,9,10(6H)-pentol, 7,11b-dihydro-
  • Hematoxylin hydrate
  • (+)-haematoxylin
  • Hematoxylin (Technical Grade)
  • (6aS,11bR)-6,6a,7,11b-tetrahydroindeno[2,1-c]chromene-3,4,6a,9,10-pentaol
  • (6aS,11bR)-7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,4,6a,9,10(6H)-pentol
  • hematoxilina
  • Benz[b]indeno[1,2-d]pyran-3,4,6a,9,10(6H)-pentol, 7,11b-dihydro-,(6aS,11bR)-
  • (6aS,11bR)-7,11b-dihydroindeno[2,1-c]chromene-3,4,6a,9,10(6H)-pentaol
  • (6aS,11bR)-7,11b-dihydroindeno[2,1-c]chromene-3,4,6a,9,10(6H)-pentol
Show all 34 synonyms
  • Ematossilina
  • rel-(6aS,11bR)-6,6a,7,11b-Tetrahydroindeno[2,1-c]chromene-3,4,6a,9,10-pentaol
  • CI 75290
  • (Z)-2-dodecened
  • C.I. Natural Black 1
  • Natural Black 1, Haematoxylin
  • Benz(b)indeno(1,2-d)pyran-3,4,6a,9,10(6H)-pentol, 7,11b-dihydro- (VAN)
  • Hematoxylin monohydrate, SAJ special grade
  • Hematoxylin Solution in Methanol, 100ug/mL

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Crystalsexp.
Melting point
100 to 120exp.
Solubility
Slightly soluble in cold, soluble in hotexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
302.28 g/molcalc.
Exact mass
302.079 Dacalc.
LogP (octanol/water)
1.32calc.
Topological polar surface area
110.4 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
0calc.
Heavy atoms
22calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CC1COc3ccccc3C21

c1ccc2c(c1)CC1COc3ccccc3C21

4 rings, 17 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hematoxylin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 79 suppliers
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Where suppliers are based

79 suppliers in 15 countries

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Hematoxylin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Biological stain in microscopy, eg, histology, manufacture of inks.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name HAEMATOXYLUM CAMPECHIANUM WOOD EXTRACT(colorant)

Pharmacological actions

  • Coloring Agents

Functional uses

  • Dye

Cosmetic functions

  • Colorant

How it is made

Extracted from the heart-wood of the tree haematoxylon campechianum l., leguminosae (logwood)

Synth: dann, hofman, angew chem 75, 1125 (1963), morsingh, robinson, tetrahedron 26, 281 (1970)...

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hematoxylin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hematoxylin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hematoxylin, based on the data on this page

What is Hematoxylin?

(+)-haematoxylin is a haematoxylin. It is an enantiomer of a (-)-haematoxylin.

What is the CAS number of Hematoxylin?

The CAS registry number of Hematoxylin is 517-28-2. Other or deprecated CAS numbers: 1412-19-7, 1621-46-1, 8005-33-2.

What is the molecular formula and weight of Hematoxylin?

The molecular formula of Hematoxylin is C16H14O6 and its molar mass is 302.28 g/mol.

What is Hematoxylin used for?

Biological stain in microscopy, eg, histology, manufacture of inks. Use classes: Cosmetics.

Is Hematoxylin hazardous?

Hematoxylin carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hematoxylin?

Hematoxylin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hematoxylin?

CompoundList lists 79 suppliers of Hematoxylin in United States, China, Germany, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Hematoxylin in India?

4 suppliers in India list Hematoxylin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Hematoxylin?

Suppliers quote Hematoxylin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hematoxylin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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