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Oncology and immunology drugs

Hinokitiol

Also known as beta-Thujaplicin, 4-Isopropyltropolone, 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-

CAS 499-44-5Formula C10H12O2Molar mass 164.20 g/molEC 207-880-7
GHS signal word: Warning. Pictograms: Harmful or irritant 32 suppliers listed
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Hinokitiol chemical structure, C10H12O2, CAS 499-44-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
499-44-5
Formula
C10H12O2
Molar mass
164.20 g/mol
EC number
207-880-7
HS code
290719
Category
Oncology and immunology drugs

What is Hinokitiol?

Plain description, key identifiers and synonyms

Beta-thujaplicin is a monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities. It has a role as an antibacterial agent, an antineoplastic agent, an antifungal agent, an antiplasmodial drug and a plant metabolite. It is a monoterpenoid, an enol and a cyclic ketone. It derives from a hydride of a cyclohepta-1,3,5-triene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one
CAS number
499-44-5 CAS number cross-checked
EC number
207-880-7
Molecular formula
C10H12O2
UNII
U5335D6EBI
MDL number
MFCD00040180
INCI name
HINOKITIOL
InChIKey
FUWUEFKEXZQKKA-UHFFFAOYSA-N
InChI
InChI=1S/C10H12O2/c1-7(2)8-4-3-5-9(11)10(12)6-8/h3-7H,1-2H3,(H,11,12)
SMILES (canonical and isomeric)
CC(C)C1=CC(=O)C(=CC=C1)O

Synonyms

  • beta-Thujaplicin
  • 4-Isopropyltropolone
  • 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)-
  • 2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one
  • 2-Hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one
  • 2-hydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
  • 2-hydroxy-4-isopropyl-2,4,6-cycloheptatriene-1-one
  • hydron, 7-oxo-5-propan-2-ylcyclohepta-1,3,5-trien-1-olate
  • Hinokitol
  • beta-Thujaplicine
  • Isopropyltropolone
  • Thujaplicin, beta
  • Tropolone, 4-isopropyl-
  • beta-Isopropyltropolon
  • 2-Hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one
  • 2-Hydroxy-4-isopropylcyclohepta-2,4,6-trien-1-one
  • beta-Isopropyltropolone
  • Hinokitiol 4-Isopropyltropolone
  • 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-4-isopropyl-
  • 2-Hydroxy-4-isopropyl-2,4,6-cyclohepta-2,4,6-trien-1-one
  • 2-hydroxy-6-isopropyl-cyclohepta-2,4,6-trien-1-one
  • ?-Thujaplicin
  • 2-hydroxy-4-isopropylcyclohepta-2,4,6-trienone
  • 2-Hydroxy-4-isopropyl-cyclohepta-2,4,6-trien-1-one
  • b-Thujaplicin
Show all 34 synonyms
  • Thujaplicin-Beta
  • A-thujaplici
  • beta -thujaplicin
  • beta -thujaplicine
  • 6-Isopropyl-tropolon
  • 2-hydroxy-4-isopropyl- 2,4,6-cycloheptatriene-1-one
  • 2,4,6-Cyclohepta
  • 4-isopropyl-tropolone
  • beta -isopropyltropolon

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
164.20 g/molcalc.
Exact mass
164.0837 Dacalc.
LogP (octanol/water)
1.88calc.
Topological polar surface area
37.3 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
12calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cccccc1

O=c1cccccc1

1 ring, 8 atoms, the Tropone ring system.

293 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hinokitiol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 32 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

32 suppliers in 7 countries

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Hinokitiol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Cosmetics.

Cosmetic ingredient, INCI name HINOKITIOL(antistatic, hair conditioning)

Pharmacological actions

  • Anti-Infective Agents
  • Antineoplastic Agents, Phytogenic
  • Iron Chelating Agents

Roles

  • antibacterial agent
  • antifungal agent
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antineoplastic agent
  • antiparasitic agent
  • antiplasmodial drug
  • antiprotozoal drug
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite

Functional uses

  • Anti-static agent
  • Fragrance
  • Softener and conditioner

Cosmetic functions

  • Antistatic
  • Hair conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hinokitiol is traded under.

HS 2907.19Indicative HS code

Monophenols, other

World exports in 2024
$671M
+2.2% vs 2023, imports $781M
2019 to 2024
Top exporters
  1. China20.1%
  2. Germany14.4%
  3. Switzerland * partner reported11.1%
Top importers
  1. China16.3%
  2. Germany10.1%
  3. South Korea8.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hinokitiol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hinokitiol, based on the data on this page

What is Hinokitiol?

Beta-thujaplicin is a monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.

What is the CAS number of Hinokitiol?

The CAS registry number of Hinokitiol is 499-44-5.

What is the molecular formula and weight of Hinokitiol?

The molecular formula of Hinokitiol is C10H12O2 and its molar mass is 164.20 g/mol.

What is Hinokitiol used for?

Use classes: Cosmetics.

Is Hinokitiol hazardous?

Hinokitiol carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hinokitiol?

Hinokitiol is usually classified under HS code 290719 (Monophenols, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hinokitiol?

CompoundList lists 32 suppliers of Hinokitiol in China, United States, Germany, France and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Hinokitiol?

Suppliers quote Hinokitiol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hinokitiol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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