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Vitamins and nutraceutical actives

Hydroxocobalamin

Also known as Cyanokit, Hydroxomin, AlphaRedisol

CAS 13422-51-0Formula C62H89CoN13O15PMolar mass 1,346.38 g/molEC 236-533-2
33 suppliers listed Drug substance
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Hydroxocobalamin chemical structure, C62H89CoN13O15P, CAS 13422-51-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Dark red, orthorhombic needles or platelets from water and acetone
Melting point
200 °C
Solubility
Moderately sol lower aliphatic alcohols, practically insoluble in acetone, ether, petrol…
HS code
293626
Category
Vitamins and nutraceutical actives
Illustrative photo, red pigment powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Hydroxocobalamin?

Plain description, key identifiers and synonyms

Hydroxocobalamin is a synthetic form of vitamin B12 that can be used as a dietary supplement to treat vitamin B12 deficiency. Upon administration, hydroxocobalamin mimics vitamin B12 and acts as an essential cofactor in various cellular reactions required for cell growth and replication, and hematopoiesis.

Hydroxocobalamin is a pharmaceutical drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
cobalt(3+), [(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate, hydroxide
CAS number
13422-51-0 CAS number cross-checked
EC number
236-533-2
Molecular formula
C62H89CoN13O15P
UNII
Q40X8H422O
InChIKey
YOZNUFWCRFCGIH-WZHZPDAFSA-K
InChI
InChI=1S/C62H90N13O14P.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;1H2/q;+3;/p-3/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1
Canonical SMILES
CC1=C2N=C(C=C3N=C(C(C)=C4[N-]C(C(CC(N)=O)C4(C)CCC(=O)NCC(C)OP(=O)([O-])OC4C(CO)OC(n5cnc6cc(C)c(C)cc65)C4O)C4(C)N=C1C(CCC(N)=O)C4(C)CC(N)=O)C(CCC(N)=O)C3(C)C)C(CCC(N)=O)C2(C)CC(N)=O.[Co+3].[OH-]
Isomeric SMILES
CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@@]\4([C@H]([C@@H]5[C@]6([C@@]([C@@H](C(=N6)/C(=C\7/[C@@]([C@@H](C(=N7)/C=C\8/C([C@@H](C(=N8)/C(=C4\[N-]5)/C)CCC(=O)N)(C)C)CCC(=O)N)(C)CC(=O)N)/C)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[OH-].[Co+3]

Synonyms

  • Cyanokit
  • Hydroxomin
  • AlphaRedisol
  • alpha Cobione
  • Hydrobamine
  • Hydrocobalamin
  • Hydrogrisevit
  • Hydroxocobemine
  • Idrogrisevit
  • Depogamma
  • Docclan
  • Docelvita
  • Duradoce
  • Hyxobamine
  • Oxobemin
  • Vibeden
  • Vitadurin
  • Axion
  • Axlon
  • Hydroxocobalamine
  • Neo-cytamen
  • Neo-macrabin
  • Neo-rojamin
  • Hidroxocobalamina
  • Hydroxycobalamine
Show all 39 synonyms
  • Idrossocobalamina
  • Ciplamin H
  • Primabalt RP
  • Hydroxocobalaminum
  • Lyovit-H
  • OH-Duphar
  • Oxolamine (arcum)
  • Duralta-12
  • Cobalex
  • Docevita
  • Hydrovit
  • Cobalamin, hydroxo-
  • Hydroxy vitamin B12
  • Ohb12

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Dark red, orthorhombic needles or platelets from water and acetoneexp.
Odour
ODORLESS OR HAS NOT MORE THAN SLIGHT ACETONE ODORexp.
Melting point
200 °Cexp.
Solubility
Moderately sol lower aliphatic alcohols, practically insoluble in acetone, ether, petroleum ether, halogenated hydrocarbons, benzene, chloroformexp.
Vapour pressure
2.06 × 10⁻¹¹ mm Hg at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,346.38 g/molcalc.
Exact mass
1,345.5671 Dacalc.
LogP (octanol/water)
3.14calc.
Topological polar surface area
494.9 Ųcalc.
Hydrogen bond donors
9calc.
Hydrogen bond acceptors
19calc.
Rotatable bonds
26calc.
Heavy atoms
92calc.
Rings
8calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.63calc.
Formal charge
0calc.
Stereocentres
15calc.
Components
3calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCC1CC2NC1=CC1=NC(=CC3=NC(=CC4=NC2CC4)CC3)CC1)NCCO[PH](=O)OC1COC(n2cnc3ccccc32)C1

O=C(CCC1CC2NC1=CC1=NC(=CC3=NC(=CC4=NC2CC4)CC3)CC1)NCCO[PH](=O)OC1COC(n2cnc3ccccc32)C1

8 rings, 48 atoms.

158 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Hydroxocobalamin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 33 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

33 suppliers in 9 countries

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Hydroxocobalamin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antidote indicated for the treatment of known or suspected cyanide poisoning.

Therapeutic category: Vitamin (hematopoietic).

Therapeutic category (veterinary): Vitamin (hematopoietic).

Veterinary medication:.

Pharmacological actions

  • Hematinics
  • Vitamin B Complex

Roles

  • anti-anaemic agent
  • anti-inflammatory agent
  • antidote
  • antidote to cyanide poisoning
  • antineoplastic agent
  • ophthalmology drug
  • pharmaceutical
  • protective agent

Pharmacology

Hydroxocobalamin is an Antidote.

How it is made

Preparaton: E.A. Kaczka et al US 2738301 (1956 to Merck & Co).

Cyanocobalamin in solution is hydrogenated @ room temp with aid of raney nickel. Solution is then exposed to air & dil with acetone. Oxidation takes place &, upon standing, hydroxocobalamin crystallizes.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hydroxocobalamin is traded under.

HS 2936.26Indicative HS code

Vitamin B12 and its derivatives

World exports in 2024
$306M
+16.8% vs 2023, imports $308M
2019 to 2024
Top exporters
  1. China47.1%
  2. France * partner reported12.0%
  3. United States10.1%
Top importers
  1. United States23.0%
  2. India * partner reported9.8%
  3. Netherlands7.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hydroxocobalamin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hydroxocobalamin, based on the data on this page

What is Hydroxocobalamin?

Hydroxocobalamin is a synthetic form of vitamin B12 that can be used as a dietary supplement to treat vitamin B12 deficiency. Upon administration, hydroxocobalamin mimics vitamin B12 and acts as an essential cofactor in various cellular reactions required for cell growth and replication, and hematopoiesis.

What is the CAS number of Hydroxocobalamin?

The CAS registry number of Hydroxocobalamin is 13422-51-0.

What is the molecular formula and weight of Hydroxocobalamin?

The molecular formula of Hydroxocobalamin is C62H89CoN13O15P and its molar mass is 1,346.38 g/mol.

What is Hydroxocobalamin used for?

Antidote indicated for the treatment of known or suspected cyanide poisoning. Therapeutic category: Vitamin (hematopoietic). Therapeutic category (veterinary): Vitamin (hematopoietic). Veterinary medication:.

Is Hydroxocobalamin hazardous?

No GHS hazard classification for Hydroxocobalamin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Hydroxocobalamin?

Hydroxocobalamin is usually classified under HS code 293626 (Vitamin B12 and its derivatives). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hydroxocobalamin?

CompoundList lists 33 suppliers of Hydroxocobalamin in China, United States, India, France and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Hydroxocobalamin in India?

5 suppliers in India list Hydroxocobalamin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Hydroxocobalamin?

Suppliers quote Hydroxocobalamin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hydroxocobalamin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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