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Central nervous system drugs

Imipramine

Also known as Melipramine, Antideprin, Berkomine

CAS 50-49-7Formula C19H24N2Molar mass 280.42 g/molEC 200-042-1
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 61 suppliers listed Drug substance
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Imipramine chemical structure, C19H24N2, CAS 50-49-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to off-white /hydrochloride/
Boiling point
160 °C
Solubility
CRYSTALS FROM ACETONE, FREELY SOL IN WATER, LESS SOL IN ALCOHOL, SPARINGLY SOL IN ACETON…
HS code
293399
Category
Central nervous system drugs
Illustrative photo, white powder in small glass vials on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Imipramine?

Plain description, key identifiers and synonyms

Imipramine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom. It has a role as an antidepressant, an adrenergic uptake inhibitor and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It derives from a hydride of a 5H-dibenzo[b,f]azepine.

Imipramine is a tricyclic antidepressant medication.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
CAS number
50-49-7 CAS number cross-checkedOther or deprecated CAS: 2241983-10-6
EC number
200-042-1
Molecular formula
C19H24N2
UNII
OGG85SX4E4
MDL number
MFCD00242921
InChIKey
BCGWQEUPMDMJNV-UHFFFAOYSA-N
InChI
InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
SMILES (canonical and isomeric)
CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31

Synonyms

  • Melipramine
  • Antideprin
  • Berkomine
  • Imidobenzyle
  • Dimipressin
  • Melipramin
  • Dynaprin
  • Intalpram
  • Nelipramin
  • Timolet
  • Irmin
  • Dpid
  • Dyna-zina
  • Impramine
  • Censtim
  • Censtin
  • Imiprin
  • Promiben
  • Iramil
  • Imipramina
  • Imipraminum
  • Psychoforin
  • Eupramin
  • Imavate
  • Surplix
Show all 39 synonyms
  • Imipramin
  • Imizinum
  • Imizine
  • N-(gamma-Dimethylaminopropyl)iminodibenzyl
  • Cristalia
  • Sermonil
  • 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
  • N-(3-Dimethylaminopropyl)-o-iminodibenzyl
  • 2,2'-(3-Dimethylaminopropylimino)bibenzyl
  • 2,2'-(3-Dimethylaminopropylimino)dibenzyl
  • 1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine
  • 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
  • Chimoreptin
  • Feinalmin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to off-white /hydrochloride/exp.
Odour
Odorless /hydrochloride/exp.
Boiling point
160 °Cexp.
Solubility
CRYSTALS FROM ACETONE, FREELY SOL IN WATER, LESS SOL IN ALCOHOL, SPARINGLY SOL IN ACETONE /HYDROCHLORIDE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
280.42 g/molcalc.
Exact mass
280.1939 Dacalc.
LogP (octanol/water)
3.88calc.
Topological polar surface area
6.48 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
4calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.37calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CCc1ccccc1N2

c1ccc2c(c1)CCc1ccccc1N2

3 rings, 15 atoms, the Iminodibenyl ring system.

268 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H400Very toxic to aquatic life.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Imipramine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 61 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

61 suppliers in 16 countries

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Imipramine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Medication: antidepressant agent (hydrochloride).

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents, Tricyclic

Roles

  • adrenergic agent
  • adrenergic uptake inhibitor
  • analgesic
  • antidepressant
  • antineoplastic agent
  • antipsychotic agent
  • anxiolytic drug
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • enzyme inhibitor
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Imipramine is a Tricyclic Antidepressant.

How it is made

Haefliger, schindler, us patent 2,554,736 (1951 to geigy), haefliger, schindler helv chim acta 37, 472 (1954).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Imipramine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Imipramine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Imipramine, based on the data on this page

What is Imipramine?

Imipramine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom. It has a role as an antidepressant, an adrenergic uptake inhibitor and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It derives from a hydride of a 5H-dibenzo[b,f]azepine.

What is the CAS number of Imipramine?

The CAS registry number of Imipramine is 50-49-7. Other or deprecated CAS numbers: 2241983-10-6.

What is the molecular formula and weight of Imipramine?

The molecular formula of Imipramine is C19H24N2 and its molar mass is 280.42 g/mol.

What is Imipramine used for?

Medication: antidepressant agent (hydrochloride). Use classes: Pharmaceuticals.

Is Imipramine hazardous?

Imipramine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Imipramine?

Imipramine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Imipramine?

CompoundList lists 61 suppliers of Imipramine in United States, China, India, United Kingdom and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Imipramine in India?

6 suppliers in India list Imipramine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Imipramine?

Suppliers quote Imipramine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Imipramine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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