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Cardiovascular and metabolic drugs

Insulin lispro

Also known as 28(B)-Lys-29(B)-Pro-Insulin, Lyumjev, insuline lispro

CAS 133107-64-9Formula C257H389N65O77S6Molar mass 5,813.72 g/mol
5 suppliers listed Drug substance
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Insulin lispro chemical structure, C257H389N65O77S6, CAS 133107-64-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
133107-64-9
Formula
C257H389N65O77S6
Molar mass
5,813.72 g/mol
HS code
293712
Category
Cardiovascular and metabolic drugs

What is Insulin lispro?

Plain description, key identifiers and synonyms

Insulin Lispro is a recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin. In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration. Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration. Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis, it has anabolic effects on many types of tissues. (NCI04)

Insulin lispro is a pharmaceutical drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4S)-4-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[(2-aminoacetyl)amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]-3-sulfanylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-5-[[(2S)-4-amino-1-[[(2S)-1-[[(2R)-1-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-5-oxopentanoic acid...
CAS number
133107-64-9 CAS number cross-checked
Molecular formula
C257H389N65O77S6
InChIKey
WNRQPCUGRUFHED-DETKDSODSA-N
InChI
InChI=1S/C158H234N40O42S2.C99H155N25O35S4/c1-79(2)57-104(181-131(213)86(15)173-136(218)102(50-53-125(211)212)179-152(234)127(84(11)12)194-148(230)107(60-82(7)8)184-145(227)113(67-95-70-166-78-172-95)189-150(232)115(74-199)176-123(208)73-170-134(216)116(75-241)191-140(222)105(58-80(3)4)182-144(226)112(66-94-69-165-77-171-94)188-138(220)101(48-51-119(161)204)178-146(228)114(68-120(162)205)190-153(235)126(83(9)10)193-132(214)98(160)61-89-31-21-18-22-32-89)139(221)185-110(64-92-40-44-96(202)45-41-92)142(224)183-106(59-81(5)6)147(229)195-128(85(13)14)154(236)192-117(76-242)135(217)169-71-121(206)174-100(49-52-124(209)210)137(219)177-99(38-29-55-167-158(163)164)133(215)168-72-122(207)175-108(62-90-33-23-19-24-34-90)141(223)186-109(63-91-35-25-20-26-36-91)143(225)187-111(65-93-42-46-97(203)47-43-93)149(231)196-129(87(16)200)155(237)180-103(37-27-28-54-159)156(238)198-56-30-39-118(198)151(233)197-130(88(17)201)157(239)240;1-12-46(9)77(121-73(134)36-100)97(156)122-76(45(7)8)95(154)108-56(25-29-75(137)138)80(139)105-54(23-27-70(102)131)83(142)117-66(40-161)93(152)119-68(42-163)94(153)124-79(48(11)127)98(157)116-64(38-126)90(149)123-78(47(10)13-2)96(155)120-67(41-162)92(151)115-63(37-125)89(148)110-58(31-44(5)6)85(144)111-59(32-49-14-18-51(128)19-15-49)86(145)106-53(22-26-69(101)130)81(140)109-57(30-43(3)4)84(143)107-55(24-28-74(135)136)82(141)113-61(34-71(103)132)88(147)112-60(33-50-16-20-52(129)21-17-50)87(146)118-65(39-160)91(150)114-62(99(158)159)35-72(104)133/h18-26,31-36,40-47,69-70,77-88,98-118,126-130,199-203,241-242H,27-30,37-39,48-68,71-76,159-160H2,1-17H3,(H2,161,204)(H2,162,205)(H,165,171)(H,166,172)(H,168,215)(H,169,217)(H,170,216)(H,173,218)(H,174,206)(H,175,207)(H,176,208)(H,177,219)(H,178,228)(H,179,234)(H,180,237)(H,181,213)(H,182,226)(H,183,224)(H,184,227)(H,185,221)(H,186,223)(H,187,225)(H,188,220)(H,189,232)(H,190,235)(H,191,222)(H,192,236)(H,193,214)(H,194,230)(H,195,229)(H,196,231)(H,197,233)(H,209,210)(H,211,212)(H,239,240)(H4,163,164,167);14-21,43-48,53-68,76-79,125-129,160-163H,12-13,22-42,100H2,1-11H3,(H2,101,130)(H2,102,131)(H2,103,132)(H2,104,133)(H,105,139)(H,106,145)(H,107,143)(H,108,154)(H,109,140)(H,110,148)(H,111,144)(H,112,147)(H,113,141)(H,114,150)(H,115,151)(H,116,157)(H,117,142)(H,118,146)(H,119,152)(H,120,155)(H,121,134)(H,122,156)(H,123,149)(H,124,153)(H,135,136)(H,137,138)(H,158,159)/t86-,87+,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,127-,128-,129-,130-;46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-,77-,78-,79-/m00/s1
Canonical SMILES
CC(C)CC(NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CO)NC(=O)CNC(=O)C(CS)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)Cc1ccccc1)C(C)C)C(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CS)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(=O)O)C(C)O)C(C)O)C(C)C.CCC(C)C(NC(=O)CN)C(=O)NC(C(=O)NC(CCC(=O)O)C(=O)NC(CCC(N)=O)C(=O)NC(CS)C(=O)NC(CS)C(=O)NC(C(=O)NC(CO)C(=O)NC(C(=O)NC(CS)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CS)C(=O)NC(CC(N)=O)C(=O)O)C(C)CC)C(C)O)C(C)C
Isomeric SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)CN.C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC6=CN=CN6)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC8=CC=CC=C8)N)O

Synonyms

  • 28(B)-Lys-29(B)-Pro-Insulin
  • Lyumjev
  • insuline lispro
  • Insulina lispro
  • Humalog Kwikpen
  • Ins humalog
  • insulinum lisprum
  • Lispro, Insulin
  • Humalog Cartridge
  • Humalog PEN
  • Kwikpen, Humalog
  • LYUMJEV KwikPen
  • Insulin lispro-aabc
  • Lyspro
  • LYUMJEV Tempo Pen
  • Admelog solostar
  • Humalog Junior KwikPen
  • Insulin Lispro KwikPen
  • Insulin lispro protamine
  • Humalog tempo pen
  • LYUMJEV Junior KwikPen
  • Insulin,lispro,human/rDNA
  • Humalog Mix50/50 KwikPen
  • Humalog Mix75/25 KwikPen
  • Insulin,lispro,protamine/rDNA
Show all 38 synonyms
  • Insulin lispro (rDNA origin)
  • Insulin Lispro Junior KwikPen
  • Insulin lispro recombinant
  • Insulin, Lys(28B)-Pro(29B)-
  • 28(B)-Lysine-29(B)-Prolineinsulin
  • Insulin, Lysyl(28B)-Prolyl(28B)-
  • Insulin lispro (genetical recombination)
  • Insulin lispro protamine recombinant
  • Insulin Lispro Protamine and Insulin Lispro Injectable Suspension
  • Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen
  • Admelog
  • Humalog
  • Humalog Mix50/50

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
5,813.72 g/molcalc.
Exact mass
5,809.6846 Dacalc.
LogP (octanol/water)
-20.98calc.
Topological polar surface area
2,299 Ųcalc.
Hydrogen bond donors
84calc.
Hydrogen bond acceptors
83calc.
Rotatable bonds
184calc.
Heavy atoms
405calc.
Rings
10calc.
Aromatic rings
9calc.
Fraction sp3 carbons
0.57calc.
Formal charge
0calc.
Stereocentres
52calc.
Components
2calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCc1ccccc1)NCC(=O)NCC(=O)NCC(=O)NC(Cc1cnc[nH]1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(Cc1cnc[nH]1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N1CCCC1

O=C(CCc1ccccc1)NCC(=O)NCC(=O)NCC(=O)NC(Cc1cnc[nH]1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(Cc1cnc[nH]1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N1CCCC1

8 rings, 163 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Insulin lispro suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 5 suppliers
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Where suppliers are based

5 suppliers in 3 countries

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Insulin lispro price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Hypoglycemic Agents

Roles

  • hypoglycemic agent
  • pharmaceutical

Pharmacology

Insulin lispro is an Insulin Analog. The chemical classification of insulin lispro is Insulin.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Insulin lispro is traded under.

HS 2937.12Indicative HS code

Insulin and its salts

World exports in 2024
$390M
−58.1% vs 2023, imports $322M
2019 to 2024
Top exporters
  1. Denmark41.4%
  2. United States16.8%
  3. Portugal13.3%
Top importers
  1. United States29.8%
  2. Italy11.0%
  3. Brazil10.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Insulin lispro is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Insulin lispro, based on the data on this page

What is Insulin lispro?

Insulin Lispro is a recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin.

What is the CAS number of Insulin lispro?

The CAS registry number of Insulin lispro is 133107-64-9.

What is the molecular formula and weight of Insulin lispro?

The molecular formula of Insulin lispro is C257H389N65O77S6 and its molar mass is 5,813.72 g/mol.

What is Insulin lispro used for?

Known uses and roles of Insulin lispro include antidiabetics in pharmaceuticals, hormones and steroids in pharmaceuticals, hypoglycemic agent, pharmaceutical and hypoglycemic agents.

Is Insulin lispro hazardous?

No GHS hazard classification for Insulin lispro is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Insulin lispro?

Insulin lispro is usually classified under HS code 293712 (Insulin and its salts). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Insulin lispro?

CompoundList lists 5 suppliers of Insulin lispro in China, United States and Puerto Rico. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Insulin lispro?

Suppliers quote Insulin lispro on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Insulin lispro

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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