Irinotecan sucrosofate
Also known as irinotecan liposome, nal-IRI, Nanoliposomal Irinotecan
Key facts
What buyers check first
- CAS number
- 1361317-83-0
- Formula
- C144H174N16O59S8
- Molar mass
- 3,329.57 g/mol
- HS code
- 293219
- Category
- Heterocyclic compounds
What is Irinotecan sucrosofate?
Plain description, key identifiers and synonyms
Irinotecan Sucrosofate is a liposomal dispersion formulated with the semisynthetic camptothecin analogue irinotecan, provided as the hydrochloride trihydrate form, which is encapsulated and entrapped within liposomes in a gelated or precipitated state as the irinotecan sucrose octasulfate (sucrosulfate) salt form, with potential antineoplastic activity. Upon administration of the liposomes containing irinotecan sucrosulfate, irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. During the S-phase, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery.
Read more
Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell, extends the circulation of irinotecan, and prolongs the duration of active therapy at the site of tumor to inhibit tumor growth.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- tetrakis([(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate), [(2R,3R,4S,5R,6R)-2-[(2S,3S,4R,5R)-3,4-disulfooxy-2,5-bis(sulfooxymethyl)oxolan-2-yl]oxy-3,5-disulfooxy-6-(sulfooxymethyl)oxan-4-yl] hydrogen sulfate
- CAS number
- 1361317-83-0
- Molecular formula
- C144H174N16O59S8
- UNII
- OL741S3N8B
- InChIKey
- BCPSLKYBXGKPIW-RTXWKGGWSA-N
- InChI
- InChI=1S/4C33H38N4O6.C12H22O35S8/c4*1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18/h4*8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36)/t4*33-;4-,5-,6-,7-,8+,9-,10+,11-,12+/m00001/s1
- Canonical SMILES
- CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(O)CC.CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(O)CC.CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(O)CC.CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)C3(O)CC.O=S(=O)(O)OCC1OC(OC2(COS(=O)(=O)O)OC(COS(=O)(=O)O)C(OS(=O)(=O)O)C2OS(=O)(=O)O)C(OS(=O)(=O)O)C(OS(=O)(=O)O)C1OS(=O)(=O)O
- Isomeric SMILES
- CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)COS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)COS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O
Synonyms
- irinotecan liposome
- nal-IRI
- Nanoliposomal Irinotecan
- Nanoparticle Liposome Formulation of Irinotecan
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 3,329.57 g/molcalc.Computed value |
|---|---|
| Exact mass | 3,326.8873 Dacalc.Computed value |
| LogP (octanol/water) | 9.59calc.Computed value |
| Topological polar surface area | 993.3 Ųcalc.Computed value |
| Hydrogen bond donors | 12calc.Computed value |
| Hydrogen bond acceptors | 59calc.Computed value |
| Rotatable bonds | 37calc.Computed value |
| Heavy atoms | 227calc.Computed value |
| Rings | 30calc.Computed value |
| Aromatic rings | 12calc.Computed value |
| Fraction sp3 carbons | 0.56calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 13calc.Computed value |
| Components | 5calc.Computed value |
| Lipinski rule of five | Fails (4 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
C1CCC(OC2CCCO2)OC1
2 rings, 12 atoms, the Tetrahydro-2-((tetrahydro-2-furanyl)oxy)-2H-pyran ring system.
213 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Irinotecan sucrosofate suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
Post one free request and suppliers who make or trade Irinotecan sucrosofate can send you quotes. Your contact details stay private until you accept a quote.
Irinotecan sucrosofate price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Roles
- antineoplastic agent
- pharmaceutical
Regulatory status
Inventories, regulations and trade controls that list this substance
No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Irinotecan sucrosofate is traded under.
Compounds containing an unfused furan ring (whether or not hydrogenated) in the…
The HS code shown for Irinotecan sucrosofate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Similar structures
Nearest neighbours by Morgan fingerprint Tanimoto similarity
![(R)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate chemical structure, C33H38N4O6, CAS 1255644-71-3](/s/UWKQSNNFCGGAFS-MGBGTMOVSA-N.svg)
![Irinotecan hydrochloride [M+H]+ chemical structure, C33H39ClN4O6, CAS 1184916-73-1](/s/GURKHSYORGJETM-UHFFFAOYSA-N.svg)
Frequently asked questions
Quick answers about Irinotecan sucrosofate, based on the data on this page
What is Irinotecan sucrosofate?
What is the CAS number of Irinotecan sucrosofate?
What is the molecular formula and weight of Irinotecan sucrosofate?
What is Irinotecan sucrosofate used for?
Is Irinotecan sucrosofate hazardous?
What is the HS code of Irinotecan sucrosofate?
Where can I buy Irinotecan sucrosofate?
What is the price of Irinotecan sucrosofate?
Guides for buyers
Practical guides that help when you source, ship or handle Irinotecan sucrosofate
- Article, SourcingHow to write an RFQ that gets fast and accurate quotesWhat suppliers need to quote quickly and comparably: exact product identity, quantity and packing, delivery terms, documents, samples and payment, with a ready to use template.Read
- Guide, Trade and logisticsHS codes for chemicals and why they matterHow the Harmonized System classifies chemicals, the chapters that matter, the rules for chemically defined compounds and mixtures, and practical steps to find the right code.Read
- Guide, Chemical identityCAS registry numbers explainedWhat a CAS number identifies, how the check digit works, why one chemical can have several numbers and what a CAS number cannot tell you about a product.Read
Get quotes for Irinotecan sucrosofate
Embed this structure on your websiteShow code
Paste this code into your page to show the 2D structure of Irinotecan sucrosofate with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.
<iframe src="https://www.compoundlist.com/embed/structure/irinotecan-sucrosofate-1361317-83-0" title="Irinotecan sucrosofate structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>Explore more in Heterocyclic compounds or HS code 293219