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Cardiovascular and metabolic drugs

Isoamyl nitrite

Also known as Isopentyl nitrite, 3-Methylbutyl nitrite, Vaporole

CAS 110-46-3Formula C5H11NO2Molar mass 117.15 g/molEC 203-770-8
GHS signal word: Danger. Pictograms: Flammable, Harmful or irritant 23 suppliers listed Drug substance
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Isoamyl nitrite chemical structure, C5H11NO2, CAS 110-46-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellowish, transparent liquid
Boiling point
99.2 °C
Density
Relative density (water = 1): 0.875
Flash point
3 °C
Solubility
Very slightly soluble in water
HS code
294200
Category
Cardiovascular and metabolic drugs
UN number
UN 1113
Illustrative photo, pale yellow liquid in sealed glass ampoules on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Isoamyl nitrite?

Plain description, key identifiers and synonyms

Isoamyl nitrite is a nitrite ester having isopentyl as the alkyl group. It has a role as a vasodilator agent and an antihypertensive agent. It is functionally related to an isoamylol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-methylbutyl nitrite
CAS number
110-46-3 CAS number cross-checked
EC number
203-770-8
Molecular formula
C5H11NO2
UNII
5N0U5TUC9Z
MDL number
MFCD00002057
InChIKey
OWFXIOWLTKNBAP-UHFFFAOYSA-N
InChI
InChI=1S/C5H11NO2/c1-5(2)3-4-8-6-7/h5H,3-4H2,1-2H3
SMILES (canonical and isomeric)
CC(C)CCON=O

Synonyms

  • Isopentyl nitrite
  • 3-Methylbutyl nitrite
  • Vaporole
  • Amilnitrite
  • Aspiral
  • Nitrous acid, 3-methylbutyl ester
  • 3-Methylbutanol nitrite
  • Pentanoli nitris
  • Nitrous acid, isopentyl ester
  • Isopentyl alcohol, nitrite
  • Nitrite, Amyl
  • Nitrous acid, 3-methyl butyl ester
  • 1-Pentyl nitrite
  • Nitramyl
  • Nitrous Acid, 2-methylbutyl Ester, mixt. with 3-methylbutylnitrite
  • Nitramyl (VAN)
  • Isoamylnitrite
  • iso-amylnitrite
  • iso-amyl nitrite
  • Vaporole (TN)
  • Aspiral (TN)
  • isopentylnitrit
  • isoamyInitrite
  • isopentylnitrite
  • Nitrous acid 3-methylbutyl ester
Show all 35 synonyms
  • Isoamyl nitrite 97%, stabilized
  • Vaporole amyl nitrite
  • Nitrite Isopentyl alcohol
  • Isopentyl nitrite, 96%
  • 3-methyl-1-nitrosooxybutane
  • isopentyl ester Nitrous acid
  • 3-methyl-1-nitrosooxy-butane
  • Isopentyl nitrite, >=97.0% (GC)
  • Isoamyl nitrite stab. with 0.2% anhyd. sodium carbonate
  • Isoamyl nitrite, stab. with 0.2% anhyd. sodium carbonate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellowish, transparent liquidexp.
Odour
Penetrating fragrant, somewhat fruity odorexp.
Taste
Pungent, aromatic tasteexp.
Boiling point
99.2 °Cexp.
Density
Relative density (water = 1): 0.875exp.
Flash point
3 °Cexp.
Autoignition temperature
209 °Cexp.
Solubility
Very slightly soluble in waterexp.
Vapour pressure
Vapor pressure, kPa at 20 °C: 3.5exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
117.15 g/molcalc.
Exact mass
117.079 Dacalc.
LogP (octanol/water)
1.73calc.
Topological polar surface area
38.66 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
8calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H225Highly flammable liquid and vapour.
  • H302Harmful if swallowed.
  • H332Harmful if inhaled.
Precautionary statements (19)
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233Keep container tightly closed.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P242Use non-sparking tools.
  • P243Take action to prevent static discharges.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P303 + P361 + P353If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P330Rinse mouth.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P235Store in a well-ventilated place. Keep cool.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1113
Transport hazard class
3
Packing group
II

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Isoamyl nitrite suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 23 suppliers
23 of 23 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

23 suppliers in 8 countries

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Isoamyl nitrite price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Used in perfumes, preparation of diazonium compounds.

Used as a vasodilator in angina therapy in the treatment of hydrogen cyanide and hydrogen sulfide poisonings, and as an industrial chemical and perfume scent.

Veterinary medication:.

Pharmacological actions

  • Vasodilator Agents

Roles

  • antihypertensive agent
  • cardiovascular drug
  • pharmaceutical
  • vasodilator agent

How it is made

Reaction of isoamyl alcohol and nitrous acid.

Prepared by nitrosation of isopentyl alcohol...

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 007-020-00-9[2]

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Amyl nitrites, Ref no: 247, Annex ref: II/247
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Isoamyl nitrite is traded under.

HS 2942.00Indicative HS code

Organic compounds not elsewhere classified in chapter 29

World exports in 2024
$589M
−43.5% vs 2023, imports $614M
2019 to 2024
Top exporters
  1. India * partner reported20.7%
  2. United States18.6%
  3. Italy10.4%
Top importers
  1. United States15.1%
  2. Italy6.7%
  3. Japan5.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Isoamyl nitrite is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Isoamyl nitrite, based on the data on this page

What is Isoamyl nitrite?

Isoamyl nitrite is a nitrite ester having isopentyl as the alkyl group. It has a role as a vasodilator agent and an antihypertensive agent. It is functionally related to an isoamylol.

What is the CAS number of Isoamyl nitrite?

The CAS registry number of Isoamyl nitrite is 110-46-3.

What is the molecular formula and weight of Isoamyl nitrite?

The molecular formula of Isoamyl nitrite is C5H11NO2 and its molar mass is 117.15 g/mol.

What is Isoamyl nitrite used for?

Used in perfumes, preparation of diazonium compounds. Used as a vasodilator in angina therapy in the treatment of hydrogen cyanide and hydrogen sulfide poisonings, and as an industrial chemical and perfume scent. Veterinary medication:.

Is Isoamyl nitrite hazardous?

Isoamyl nitrite carries the GHS signal word "Danger". Main hazards: highly flammable liquid and vapour, harmful if swallowed, harmful if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Isoamyl nitrite?

Isoamyl nitrite is usually classified under HS code 294200 (XIII. OTHER ORGANIC COMPOUNDS, other organic compounds). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Isoamyl nitrite?

CompoundList lists 23 suppliers of Isoamyl nitrite in China, India, United States, Canada and 4 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Isoamyl nitrite in India?

5 suppliers in India list Isoamyl nitrite on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Isoamyl nitrite?

Suppliers quote Isoamyl nitrite on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Isoamyl nitrite

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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