CompoundList
Sign in
Amino acids and derivatives

L-Valine

Also known as valine, (S)-Valine, (2S)-2-amino-3-methylbutanoic acid

CAS 72-18-4Formula C5H11NO2Molar mass 117.15 g/molEC 200-773-6
250 suppliers listed Drug substance
Get quotes Compare 250 suppliers
L-Valine chemical structure, C5H11NO2, CAS 72-18-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Leaflets from water + alcohol
Melting point
315 °C
Boiling point
Sublimes
Density
1.23 g/cm³ at 25 °C
Solubility
Solubility in water at 0 °C: 83.4 g/L, at 25 °C: 88.5 g/L, at 50 °C: 96.2 g/L, at 65 °C:…
HS code
292249
Category
Amino acids and derivatives
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is L-Valine?

Plain description, key identifiers and synonyms

L-valine is the L-enantiomer of valine. It has a role as a micronutrient, a nutraceutical, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite. It is a L-alpha-amino acid, a pyruvate family amino acid, a valine and a proteinogenic amino acid. It is a conjugate base of a L-valinium. It is a conjugate acid of a L-valinate. It is an enantiomer of a D-valine. It is a tautomer of a L-valine zwitterion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-amino-3-methylbutanoic acid
CAS number
72-18-4 CAS number cross-checkedOther or deprecated CAS: 516-06-3, 7004-03-7
EC number
200-773-6
Molecular formula
C5H11NO2
UNII
HG18B9YRS7
MDL number
MFCD00064220
InChIKey
KZSNJWFQEVHDMF-BYPYZUCNSA-N
InChI
InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1
Canonical SMILES
CC(C)C(N)C(=O)O
Isomeric SMILES
CC(C)[C@@H](C(=O)O)N

Synonyms

  • valine
  • (S)-Valine
  • (2S)-2-amino-3-methylbutanoic acid
  • (S)-2-Amino-3-methylbutanoic acid
  • 2-Amino-3-methylbutyric acid
  • (S)-2-Amino-3-methylbutyric acid
  • valina
  • L-alpha-Amino-beta-methylbutyric acid
  • L-valin
  • Valinum
  • (S)-alpha-Amino-beta-methylbutyric acid
  • l-(+)-alpha-Aminoisovaleric acid
  • L-Val
  • 2-amino-3-methylbutanoate
  • (2S)-2-amino-3-methylbutanoate
  • l valine
  • L-Valine High
  • L-Valine 7429
  • L-Valine High 7430
  • (2S)-2-amino-3-methylbutanoate, hydron
  • (2S)-2-azaniumyl-3-methylbutanoate
  • H-Val-OH
  • Butanoic acid, 2-amino-3-methyl-
  • Valine (VAN)
  • Valine, l-
Show all 35 synonyms
  • L(+)-alpha-Aminoisovaleric acid
  • Butanoic acid, 2-amino-3-methyl-, (S)-
  • 2-Amino-3-methylbutyric acid, (S)-
  • 2-Amino-3-methylbutanoic acid, (S)-
  • val
  • (L)-valine
  • Valine (L-Valine)
  • L-2-Amino-3-methylbutanoic acid
  • 2-aminoisovaleric acid
  • (+)-valine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Leaflets from water + alcoholexp.
Melting point
315 °Cexp.
Boiling point
Sublimesexp.
Density
1.23 g/cm³ at 25 °Cexp.
Solubility
Solubility in water at 0 °C: 83.4 g/L, at 25 °C: 88.5 g/L, at 50 °C: 96.2 g/L, at 65 °C: 102.4 g/Lexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
117.15 g/molcalc.
Exact mass
117.079 Dacalc.
LogP (octanol/water)
0.05calc.
Topological polar surface area
63.32 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
8calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

L-Valine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 250 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

250 suppliers in 37 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

L-Valine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Dietary supplement, culture media, biochemical and nutritional investigations.[Lewis RJ Sr, Hawley's Condensed Chemical Dictionary 15th ed Wiley (2007).

Biological activities: antiencephalopathic, essential amino acid, flavor additive (Valine).

Industrial uses: Catalyst.

Consumer uses: Catalyst.

Use classes: Cosmetics.

Roles

  • Escherichia coli metabolite
  • Saccharomyces cerevisiae metabolite
  • algal metabolite
  • animal metabolite
  • bacterial metabolite
  • eukaryotic metabolite
  • food component
  • fungal metabolite
  • human metabolite
  • mammalian metabolite
  • metabolite
  • micronutrient
  • mouse metabolite
  • nutraceutical
  • nutrient
  • pharmaceutical
  • physiological role
  • prokaryotic metabolite

Functional uses

  • Flavouring and nutrient
  • Fragrance

Pharmacology

Valine is an aliphatic and extremely hydrophobic essential amino acid in humans related to leucine, Valine is found in many proteins, mostly in the interior of globular proteins helping to determine three-dimensional structure. A glycogenic amino acid, valine maintains mental vigor, muscle coordination, and emotional calm. Valine is obtained from soy, cheese, fish, meats and vegetables. Valine supplements are used for muscle growth, tissue repair, and energy. (NCI04)

How it is made

Hydrolysis of proteins, synthesized by the reaction of ammonia with alpha-chloroisovaleric acid.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code L-Valine is traded under.

HS 2922.49Indicative HS code

Amino-acids, other than those containing more than one kind of oxygen function, and…

World exports in 2024
$3.88B
−11.5% vs 2023, imports $3.87B
2019 to 2024
Top exporters
  1. China38.7%
  2. India * partner reported8.3%
  3. Germany8.1%
Top importers
  1. United States13.4%
  2. Germany11.1%
  3. Japan6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for L-Valine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about L-Valine, based on the data on this page

What is L-Valine?

L-valine is the L-enantiomer of valine. It has a role as a micronutrient, a nutraceutical, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite.

What is the CAS number of L-Valine?

The CAS registry number of L-Valine is 72-18-4. Other or deprecated CAS numbers: 516-06-3, 7004-03-7.

What is the molecular formula and weight of L-Valine?

The molecular formula of L-Valine is C5H11NO2 and its molar mass is 117.15 g/mol.

What is L-Valine used for?

Dietary supplement, culture media, biochemical and nutritional investigations.[Lewis RJ Sr, Hawley's Condensed Chemical Dictionary 15th ed Wiley (2007). Biological activities: antiencephalopathic, essential amino acid, flavor additive (Valine). Industrial uses: Catalyst. Consumer uses: Catalyst. Use classes: Cosmetics.

Is L-Valine hazardous?

No GHS hazard classification for L-Valine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of L-Valine?

L-Valine is usually classified under HS code 292249 (Amino-acids, other than those containing more than one kind of oxygen function, and…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy L-Valine?

CompoundList lists 250 suppliers of L-Valine in China, United States, India, Germany and 33 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy L-Valine in India?

22 suppliers in India list L-Valine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of L-Valine?

Suppliers quote L-Valine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle L-Valine

Get quotes for L-Valine

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell L-Valine
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of L-Valine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/l-valine-72-18-4" title="L-Valine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Amino acids and derivatives or HS code 292249

250 suppliers
Free quotes, contact stays private
Get quotes