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Insecticides and acaricides

Isofenphos

Also known as Isophenphos, Oftanol, Amaze

CAS 25311-71-1Formula C15H24NO4PSMolar mass 345.40 g/molEC 246-814-1
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Hazardous to the environment
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Isofenphos chemical structure, C15H24NO4PS, CAS 25311-71-1
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Oil
Melting point
<-12
Boiling point
120 °C
Density
1.131 @ 20 °C
Solubility
In water, 22.1 mg/l @ 20 °C
HS code
292019
Category
Insecticides and acaricides
UN number
UN 3018
Illustrative photo, a closed 1000 litre IBC tote in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Isofenphos?

Plain description, key identifiers and synonyms

Isofenphos is an organothiophosphate insecticide, a member of salicylates, an isopropyl ester, an organic phosphonate and a phosphonic ester. It has a role as an agrochemical and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is functionally related to an isopropyl salicylate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
propan-2-yl 2-[ethoxy-(propan-2-ylamino)phosphinothioyl]oxybenzoate
CAS number
25311-71-1 CAS number cross-checkedOther or deprecated CAS: 103982-06-5, 103982-07-6
EC number
246-814-1
Molecular formula
C15H24NO4PS
UNII
0514MAW53A
InChIKey
HOQADATXFBOEGG-UHFFFAOYSA-N
InChI
InChI=1S/C15H24NO4PS/c1-6-18-21(22,16-11(2)3)20-14-10-8-7-9-13(14)15(17)19-12(4)5/h7-12H,6H2,1-5H3,(H,16,22)
SMILES (canonical and isomeric)
CCOP(=S)(NC(C)C)OC1=CC=CC=C1C(=O)OC(C)C

Synonyms

  • Isophenphos
  • Oftanol
  • Amaze
  • Discus
  • Pyrfon
  • 40 SD
  • SRA 12869
  • SRA 128691
  • O-Ethyl O-(2-isopropoxycarbonyl)phenyl isopropylphosphoramidothioate
  • 1-Methylethyl-2-((ethoxy((1-methylethyl)amino)phosphinothioyl)oxy) benzoate
  • Isopropyl salicylate O-ester with O-ethylisopropylphosphoramidothioate
  • 2-((Ethoxy((1-methylethyl)amino)phosphinothioyl)oxy)benzoic acid 1-methylethyl ester
  • 2-[[ethoxy[(1-methylethyl)amino]phosphinothioyl]oxy]benzoic acid 1-methylethyl ester
  • propan-2-yl 2-((ethoxy((propan-2-yl)amino)sulfanylidene-$l^(5)-phosphanyl)oxy)benzoate
  • propan-2-yl 2-({ethoxy[(propan-2-yl)amino]sulfanylidene-$l^{5}-phosphanyl}oxy)benzoate
  • LE-Mat
  • Amidocid
  • Pryfon
  • propan-2-yl 2-[ethoxy-(propan-2-ylamino)phosphinothioyl]oxybenzoate
  • Isopropylsalicylate, O-ester with O-ethyl isopropylphosphoramidothioate
  • Benzoic acid, 2-[[ethoxy[(1-methylethyl)amino]phosphinothioyl]oxy]-, 1-methylethyl ester
  • isopropyl 2-((ethoxy(isopropylamino)phosphorothioyl)oxy)benzoate
  • Isophenphos [ISO-French]
  • propan-2-yl 2-({ethoxy[(propan-2-yl)amino]phosphorothioyl}oxy)benzoate
  • Benzoic acid, 2-((ethoxy((1-methylethyl)amino)phosphinothioyl)oxy)-, 1-methylethyl ester
Show all 34 synonyms
  • isopropyl 2-{[ethoxy(isopropylamino)phosphorothioyl]oxy}benzoate
  • Isopropyl O-(ethoxy(isopropylamino)phosphinothioyl)salicylate
  • Isopropyl O-(ethoxy-N-isopropylamino(thiophosphoryl))salicylate
  • Isopropyl salicylate ester of O-ethyl isopropylphosphoramidothioate
  • 2-(O-Aethyl-N-isopropylamidothiophosphoryloxy)-benzosaeure-isopropylester
  • Phosphoramidothioic acid, isopropyl-, O-ethyl O-(2-isopropoxycarbonylphenyl) ester
  • Salicylic acid, isopropyl ester, O-ester with O-ethyl isopropylphosphoramidothioate
  • Isofenphos, analytical standard
  • Hoqadatxfboegg-uhfffaoysa-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Oilexp.
Odour
Characteristicexp.
Melting point
<-12exp.
Boiling point
120 °Cexp.
Density
1.131 @ 20 °Cexp.
Solubility
In water, 22.1 mg/l @ 20 °Cexp.
Vapour pressure
3.00 × 10⁻⁶ mm Hg @ 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
345.40 g/molcalc.
Exact mass
345.1164 Dacalc.
LogP (octanol/water)
3.89calc.
Topological polar surface area
56.79 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
8calc.
Heavy atoms
22calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.53calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H301Toxic if swallowed.
  • H311Toxic in contact with skin.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 3018

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

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Isofenphos price

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Uses and applications

What the substance is used for, by industry and function

Isofenphos, marketed under the basic producer's trade name Oftanol, is currently used in the United States on turf & ornamental trees & shrubs to control white grubs, mole crickets, & other insects (mostly subterranean species). According to recent usage data, about 60% of the Isofenphos active ingredient produced annually is used on golf courses, the remainder is used on residential & public turf sites. Isofenphos ... was first registered in the United States in 1980 by Bayer Corporation for use on corn for control of the corn rootworm. In recent years, all of the food uses & the various residential indoor uses (including the termiticide use) were dropped by the basic producer. ... The remaining turf & ornamental uses of the pesticide are now no longer supported. ... All food tolerances for Isofenphos have been revoked (effective January 1999).

Insecticide, control of cabbage root flies, onion flies, corn rootworms, white grubs, wireworms, and other soil insects. (Former use).

Pharmacological actions

  • Insecticides

Roles

  • agrochemical
  • enzyme inhibitor

Functional uses

  • Biocide

Pharmacology

Isofenphos is a synthetic organophosphate acetylcholinesterase inhibitor, derived from an isopropyl salicylate, that is used as a pesticide. It is characterized as a colorless oily liquid with a characteristic odor, and exposure occurs by inhalation, ingestion, or contact.

How it is made

Isopropanol + salicylic acid + thiophosphoryl chloride + isopropylamine + ethanol (esterification/dehydrochlorination/dehydrochlorination/dehydrochlorination)

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-129-00-8

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Isofenphos is traded under.

HS 2920.19Indicative HS code

Thiophosphoric esters (phosphorothioates) and their salts, their halogenated…

World exports in 2024
$131M
+2.1% vs 2023, imports $115M
2019 to 2024
Top exporters
  1. China59.7%
  2. Japan17.6%
  3. Germany9.1%
Top importers
  1. Brazil16.0%
  2. United States13.3%
  3. India * partner reported8.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Isofenphos is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Isofenphos, based on the data on this page

What is Isofenphos?

Isofenphos is an organothiophosphate insecticide, a member of salicylates, an isopropyl ester, an organic phosphonate and a phosphonic ester. It has a role as an agrochemical and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is functionally related to an isopropyl salicylate.

What is the CAS number of Isofenphos?

The CAS registry number of Isofenphos is 25311-71-1. Other or deprecated CAS numbers: 103982-06-5, 103982-07-6.

What is the molecular formula and weight of Isofenphos?

The molecular formula of Isofenphos is C15H24NO4PS and its molar mass is 345.40 g/mol.

What is Isofenphos used for?

Isofenphos, marketed under the basic producer's trade name Oftanol, is currently used in the United States on turf & ornamental trees & shrubs to control white grubs, mole crickets, & other insects (mostly subterranean species).

Is Isofenphos hazardous?

Isofenphos carries the GHS signal word "Danger". Main hazards: toxic if swallowed, toxic in contact with skin, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Isofenphos?

Isofenphos is usually classified under HS code 292019 (Thiophosphoric esters (phosphorothioates) and their salts, their halogenated…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Isofenphos?

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What is the price of Isofenphos?

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Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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