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Herbicides

Isoproturon

Also known as Graminon, Tolkan, 3-(4-Isopropylphenyl)-1,1-dimethylurea

CAS 34123-59-6Formula C12H18N2OMolar mass 206.29 g/molEC 251-835-4
GHS signal word: Warning. Pictograms: Serious health hazard, Hazardous to the environment 27 suppliers listed
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Isoproturon chemical structure, C12H18N2O, CAS 34123-59-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless crystals
Melting point
158 °C
Density
1.2 at 20 °C
Flash point
100 °C
Solubility
In water, 65 mg/L at 22 °C
HS code
292421
Category
Herbicides
Illustrative photo, colourless crystals beside a jumbo bulk bag in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Isoproturon?

Plain description, key identifiers and synonyms

Isoproturon is a member of the class of phenylureas that is 1,1-dimethylurea substituted by a p-cumenyl group at position 3. A selective, systemic herbicide used to control annual grasses and broadleaf weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life, there have also been concerns about its endocrine-disrupting properties. It has a role as a herbicide, an agrochemical, a xenobiotic and an environmental contaminant.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,1-dimethyl-3-(4-propan-2-ylphenyl)urea
CAS number
34123-59-6 CAS number cross-checked
EC number
251-835-4
Molecular formula
C12H18N2O
UNII
66066K098P
MDL number
MFCD00078684
InChIKey
PUIYMUZLKQOUOZ-UHFFFAOYSA-N
InChI
InChI=1S/C12H18N2O/c1-9(2)10-5-7-11(8-6-10)13-12(15)14(3)4/h5-9H,1-4H3,(H,13,15)
SMILES (canonical and isomeric)
CC(C)C1=CC=C(C=C1)NC(=O)N(C)C

Synonyms

  • Graminon
  • Tolkan
  • 3-(4-Isopropylphenyl)-1,1-dimethylurea
  • Arelon
  • Belgran
  • Arelon R
  • Nocilon
  • IPU Stefes
  • IP-Flo
  • Hytane 500L
  • Zodiac TX
  • DPX 6774
  • 3-p-Cumenyl-1,1-dimethylurea
  • HOE 16410
  • N-4-Isopropylphenyl-N,N-dimethylurea
  • IP 50
  • CL 12150
  • Urea, 3-p-cumenyl-1,1-dimethyl-
  • N,N-Dimethyl-N'-(4-(1-methylethyl)phenyl)urea
  • N-(4-Isopropylphenyl)-N',N'-dimethylharnstoff
  • 3-(4-isopropylphenyl)-1,1-dimethyl-urea
  • N-(Isopropyl-4-phenyl)-N',N'-dimethyluree
  • 35689 R.P.
  • N,N-Dimethyl-N'-[4-(1-methylethyl)phenyl]urea
  • 1,1-dimethyl-3-[4-(propan-2-yl)phenyl]urea
Show all 34 synonyms
  • 1,1-dimethyl-3-(4-(propan-2-yl)phenyl)urea
  • N'-(4-(1-methylethyl)phenyl)-N,N-dimethylurea
  • 3,3-dimethyl-1-[4-(propan-2-yl)phenyl]urea
  • 1,1-dimethyl-3-(4-propan-2-ylphenyl)urea
  • Urea, N,N-dimethyl-N'-[4-(1-methylethyl)phenyl]-
  • Urea, 1,1-dimethyl-3-(p-isopropylphenyl)-
  • Protugan
  • Urea, N,N-dimethyl-N'-(4-(1-methylethyl)phenyl)-
  • Tolken

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless crystalsexp.
Melting point
158 °Cexp.
Density
1.2 at 20 °Cexp.
Flash point
100 °Cexp.
Solubility
In water, 65 mg/L at 22 °Cexp.
Vapour pressure
9.1 × 10⁻³ mPa /2.47 × 10⁻⁸ mm Hg/ at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
206.29 g/molcalc.
Exact mass
206.1419 Dacalc.
LogP (octanol/water)
2.9calc.
Topological polar surface area
32.34 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
2calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H351Suspected of causing cancer.
  • H373May cause damage to organs through prolonged or repeated exposure.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Isoproturon suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 27 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

27 suppliers in 7 countries

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Isoproturon price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pre- and post-emergence herbicide for control of annual grasses and broad-leaved weeds.

Herbicide.

Use classes: Pharmaceuticals, Pesticides, Herbicides.

Pharmacological actions

  • Herbicides

Roles

  • agrochemical
  • environmental contaminant
  • herbicide
  • pesticide
  • xenobiotic

How it is made

Isoproturon is produced by reaction of 4-isopropylphenyl isocyanate with dimethylamine.

Preparation ...: C. W. Todd, United States of America patent 2655447 (1953 to du Pont), Belgium patent 770928 (1971 to Pepro), A. Thizy et al., United States of America patent 4295877 (1981 to Philagro).

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 006-044-00-7

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: 3-(4-Isopropylphenyl)-1,1-dimethylurea (Isoproturon - ISO), Ref no: 1061, Annex ref: II/1061

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Isoproturon is traded under.

HS 2924.21Indicative HS code

Ureines and their derivatives, salts thereof

World exports in 2024
$149M
+12.5% vs 2023, imports $208M
2019 to 2024
Top exporters
  1. Germany25.4%
  2. China14.4%
  3. Israel12.0%
Top importers
  1. Brazil28.2%
  2. United States14.0%
  3. Japan10.0%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Isoproturon is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Isoproturon, based on the data on this page

What is Isoproturon?

Isoproturon is a member of the class of phenylureas that is 1,1-dimethylurea substituted by a p-cumenyl group at position 3.

What is the CAS number of Isoproturon?

The CAS registry number of Isoproturon is 34123-59-6.

What is the molecular formula and weight of Isoproturon?

The molecular formula of Isoproturon is C12H18N2O and its molar mass is 206.29 g/mol.

What is Isoproturon used for?

Pre- and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide. Use classes: Pharmaceuticals, Pesticides, Herbicides.

Is Isoproturon hazardous?

Isoproturon carries the GHS signal word "Warning". Main hazards: suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Isoproturon?

Isoproturon is usually classified under HS code 292421 (Ureines and their derivatives, salts thereof). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Isoproturon?

CompoundList lists 27 suppliers of Isoproturon in China, India, United States, Cape Verde and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Isoproturon in India?

4 suppliers in India list Isoproturon on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Isoproturon?

Suppliers quote Isoproturon on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Isoproturon

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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