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Oncology and immunology drugs

Ixazomib

Also known as MLN 2238, MLN-9708 FREE BASE, [(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid

CAS 1072833-77-2Formula C14H19BCl2N2O4Molar mass 361.03 g/molEC 810-246-8
GHS signal word: Danger. Pictograms: Serious health hazard 49 suppliers listed Drug substance
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Ixazomib chemical structure, C14H19BCl2N2O4, CAS 1072833-77-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1072833-77-2
Formula
C14H19BCl2N2O4
Molar mass
361.03 g/mol
EC number
810-246-8
HS code
293190
Category
Oncology and immunology drugs

What is Ixazomib?

Plain description, key identifiers and synonyms

Ixazomib is a glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma. It has a role as an antineoplastic agent, a drug metabolite, a proteasome inhibitor, an apoptosis inducer and an orphan drug. It is a member of benzamides, a dichlorobenzene, a glycine derivative and a member of boronic acids.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
CAS number
1072833-77-2 CAS number cross-checked
EC number
810-246-8
Molecular formula
C14H19BCl2N2O4
UNII
71050168A2
MDL number
MFCD18251438
InChIKey
MXAYKZJJDUDWDS-LBPRGKRZSA-N
InChI
InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1
Canonical SMILES
CC(C)CC(NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
Isomeric SMILES
B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O

Synonyms

  • MLN 2238
  • MLN-9708 FREE BASE
  • [(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid
  • Boronic acid, b-((1R)-1-((2-((2,5-dichlorobenzoyl)amino)acetyl)amino)-3-methylbutyl)-
  • [(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]boronic acid
  • ((1R)-1-((2,5-Dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid
  • ixazomibum
  • ((1R)-1-((2-((2,5-dichlorobenzoyl)amino)acetyl)amino)-3-methylbutyl)boronic acid
  • ((1R)-1-(2-((2,5-dichlorophenyl)formamido)acetamido)-3-methylbutyl)boronic acid
  • Boronic acid, B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-
  • (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid
  • (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
  • Ixozamib
  • Ixazomib (MLN2238)
  • Ixazomib(MLN2238)
  • Ixazomib (USAN)
  • [(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methyl-butyl]boronic acid
  • C14H19BCl2N2O4
  • (R)-1-[2-(2,5-Dichlorobenzamido)acetamido]-3-methylbutylboronic Acid
  • Ixazomib (Standard)
  • MLN2238(Ixazomib)
  • N-[(1R)-1-borono-3-methylbutyl]-N(2)-(2,5-dichlorobenzoyl)glycinamide
  • MLN 2238, B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
361.03 g/molcalc.
Exact mass
360.0815 Dacalc.
LogP (octanol/water)
1.27calc.
Topological polar surface area
98.66 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
7calc.
Heavy atoms
23calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H360May damage fertility or the unborn child.
  • H362May cause harm to breast-fed children.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ixazomib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 49 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

49 suppliers in 11 countries

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Ixazomib price

Indicative price range per kg from live supplier offers

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Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Protease Inhibitors

Roles

  • animal metabolite
  • anti-HIV agent
  • anti-anaemic agent
  • anti-inflammatory agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • apoptosis inducer
  • drug metabolite
  • eukaryotic metabolite
  • human metabolite
  • human xenobiotic metabolite
  • mammalian metabolite
  • metabolite
  • orphan drug
  • pharmaceutical
  • proteasome inhibitor
  • xenobiotic metabolite

Pharmacology

Ixazomib is a Proteasome Inhibitor. The mechanism of action of ixazomib is as a Proteasome Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ixazomib is traded under.

HS 2931.90Indicative HS code

Organo-inorganic compounds, other than tetramethyl lead, tetraethyl lead, tributyltin compounds…

World exports in 2024
$3.97B
+5.3% vs 2023, imports $3.93B
2019 to 2024
Top exporters
  1. China28.3%
  2. United States15.6%
  3. Germany15.1%
Top importers
  1. United States14.6%
  2. China13.0%
  3. South Korea8.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Ixazomib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ixazomib, based on the data on this page

What is Ixazomib?

Ixazomib is a glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.

What is the CAS number of Ixazomib?

The CAS registry number of Ixazomib is 1072833-77-2.

What is the molecular formula and weight of Ixazomib?

The molecular formula of Ixazomib is C14H19BCl2N2O4 and its molar mass is 361.03 g/mol.

What is Ixazomib used for?

Known uses and roles of Ixazomib include anticancer drugs in pharmaceuticals, building blocks in research and laboratory, animal metabolite, anti-hiv agent, anti-anaemic agent and 17 more.

Is Ixazomib hazardous?

Ixazomib carries the GHS signal word "Danger". Main hazards: may damage fertility or the unborn child, may cause harm to breast-fed children. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ixazomib?

Ixazomib is usually classified under HS code 293190 (X. ORGANO-INORGANIC COMPOUNDS, HETEROCYCLIC COMPOUNDS, NUCLEIC ACIDS AND THEIR SALTS…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ixazomib?

CompoundList lists 49 suppliers of Ixazomib in China, United States, Germany, Canada and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Ixazomib in India?

1 supplier in India list Ixazomib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Ixazomib?

Suppliers quote Ixazomib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ixazomib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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